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In vivo effect of sublethal concentrations of albendazole metabolites on the structure of the reproductive organs of Dictyocaulus viviparus

Published online by Cambridge University Press:  05 June 2009

A.M.M. Osman ,
D.E. Jacobs  and
J.M. Plummer
A.M.M. Osman
Affiliation:
Department of Pathology and Infectious Diseases and Department of Veterinary Basic Sciences, The Royal Veterinary College (University of London), North Mymms, Hatfield, Herts, AL9 7TA, UK
D.E. Jacobs
Affiliation:
Department of Pathology and Infectious Diseases and Department of Veterinary Basic Sciences, The Royal Veterinary College (University of London), North Mymms, Hatfield, Herts, AL9 7TA, UK
J.M. Plummer
Affiliation:
Department of Pathology and Infectious Diseases and Department of Veterinary Basic Sciences, The Royal Veterinary College (University of London), North Mymms, Hatfield, Herts, AL9 7TA, UK
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Abstract

Dictyocaulus viviparus were harvested from calves treated daily with albendazole at dose-rates sub-lethal to this parasite and from matched untreated calves. Male and female reproductive tracts from the worms were examined by light and transmission electron microscopy. A first description of the testis of this nematode is provided. Cell division in the germinal zone of both male and female worms was arrested by in vivo exposure to albendazole metabolites and the cytoplasmic threads connecting the germinal cells to the rachis disappeared. In male worms from treated calves, the rachis was absent from the growth zone and severe ultrastructural damage of spermatogonia, spermatocytes and spermatozoa was apparent. In female worms, the rachis remained intact in the growth zone, obvious abnormalities being confined to the germinal zone, where the cytoplasm of the oogonia was disrupted and few nuclei seen, and to the uteri and ovijector which contained only undifferentiated ova. The detrimental effects of albendazole metabolites on male and female worms were quickly reversed after withdrawal of medication.

Type
Research Papers
Information
Journal of Helminthology , Volume 68 , Issue 2 , June 1994 , pp. 161 - 166
Copyright
Copyright © Cambridge University Press 1994

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