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Recovery from arrhythmias in lambs infected with Strongyloides papillosus following worm elimination

Published online by Cambridge University Press:  05 June 2009

Y. Nakamura ,
C. Ooba  and
H. Hirose
Y. Nakamura
Affiliation:
National Institute of Animal Health, Shichinohe, Aomori 039-25, Japan
C. Ooba
Affiliation:
Hokkaido Prefectural Kamikawa Livestock Hygiene Service Center, Asahikawa, Hokkaido 071, Japan
H. Hirose
Affiliation:
Kyushu Research Station, National Institute of Animal Health, Kagoshima, Kagoshima 891-01, Japan
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Abstract

Calves and lambs heavily infected with Strongijloides papillosus develop cardiac arrest by ventricular fibrillation which is preceded by continuous sinus tachycardia and prolongation of the PQ interval during the patent infection. In the present study, cardiac rhythms following anthelmintic treatment were investigated in lambs infected with S. papillosus to ascertain whether cardiac disorders due to the infection are based on a reversible and curable change. Eight lambs were given a lethal dose of S. papillosus. Five of the animals were injected with ivermectin when they developed continuous sinus tachycardia and prolongation of the PQ interval. The other three animals served as untreated controls. In the treated animals, elevated heart rates and PQ intervals began to decrease between 10 and 21 h, then continuous sinus tachycardia and prolongation of PQ interval disappeared within 39 h of treatment. No arrhythmias were detected after the disappearance of sinus tachycardia. Faecal egg counts became negative within 61 h of treatment. Only a few worms were collected from the small intestine at necropsy. The control animals developed ventricular fibrillation by 349 h after infection, having high faecal egg counts and intestinal worm burdens. These results indicate that cardiac disorders generated by S. papillosus infection are reversible and curable following worm elimination.

Type
Research Papers
Information
Journal of Helminthology , Volume 72 , Issue 1 , March 1998 , pp. 43 - 46
Copyright
Copyright © Cambridge University Press 1998

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References

Bogan, J.A.McKellar, Q.A. (1988) The pharmacodynamics of ivermectin in sheep and cattle. Journal of Veterinary Pharmacology and Therapeutics 11, 260–268.Google Scholar
Detweiler, D.K. (1993) Regulation of the heart. pp. 170–183 in Swenson, M.J.Reece, W.O.(Eds) Dukes physiology of domestic animals. New York, Cornell University Press.Google Scholar
Hearse, D.J. (1977) Reperfusion of the ischemic myocardium. Journal of Molecular and Cellular Cardiology 9, 605–616.Google Scholar
Manning, A.S.Hearse, D.J. (1984) Reperfusion induced arrhythmias: mechanisms and prevention. Journal of Molecular and Cellular Cardiology 16, 497–518.Google Scholar
Marriner, S.E., McKinnon, I.Bogan, J.A. (1987) The pharmacokinetics of ivermectin after oral and subcutaneous administration to sheep and horses. Journal of Veterinary Pharmacology and Therapeutics 10, 175–179.Google Scholar
Nagai, R.Yazaki, Y. (1990) Measurement of serum cardiac myosin light chain. RinshoKensa 34, 1171–1177 (in Japanese).Google Scholar
Nakamura, Y., Tsuji, N., Taira, N.Hirose, H. (1994a) Parasitic females of Strongyloides papillosus as a pathogenetic stage for sudden cardiac death in infected lambs. Journal of Veterinary Medical Science 56, 723–727.Google ScholarPubMed
Nakamura, Y., Tsuji, N.Taira, N. (1994b) Wasting condition under normal cardiac rhythms in rabbits following Strongyloides papillosus infection. Journal of Veterinary Medical Science 56, 1005–1007.Google Scholar
Nakanishi, N., Nakamura, Y., Ura, S., Tsuji, N., Taira, N., Tanimura, N.Kubo, M. (1993) Sudden death of calves by experimental infection with Strongyloides papillosus. III. Hematological, biochemical and histological examinations. Veterinary Parasitology 47, 67–76.Google Scholar
Petersen, M.B., Vrady, M., Bjrn, H.Nansen, P. (1996) Efficacies of different doses of ivermectin against male, female and L4 Oesophagostomum dentatum in pigs. Veterinary Parasitology 65, 55–63.Google Scholar
Robinson, W.F.Maxie, M.G. (1985) The cardiovascular system. pp. 1–81 in Jubb, K.V.F., Kennedy, P.C.Palmer, N.(Eds) Pathology of domestic animals, Vol.3. San Diego, Academic Press.Google Scholar
Sesaki, K., Ohi, S.Sumino, T. (1971) Studies on the electrocardiogram of the sheep. IV. The normal patterns and values in lead AB and standard limb lead. Bulletin for College of Agriculture of Utsunomiya University (Japan) 8, 113–121 (in Japanese with English summary).Google Scholar
Tassi, P., Barth, D.Gross, S.J. (1990) The efficacy of ivermectin against Strongyloides papillosus in cattle. Parassitologia 32, 347–352.Google Scholar
Tsuji, N., Itabisashi, T., Nakamura, Y., Taira, N., Kubo, M., Ura, S.Genno, A. (1992) Sudden cardiac death in calves with experimental heavy infection of Strongyloides papillosus. Journal of Veterinary Medical Science 54, 1137–1143.Google Scholar
Yazwinski, T.A., Greenway, T., Presson, B.L., Pote, L.M., Featherstone, H.Williams, M. (1983) Antiparasitic efficacy of ivermectin in naturally parasitized sheep. American Journal of Veterinary Research 44, 2186–2187.Google Scholar