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Setaria digitata in advancing our knowledge of human lymphatic filariasis

Published online by Cambridge University Press:  30 April 2015

A.N.I. Perumal ,
Y.I.N.S. Gunawardene  and
R.S. Dassanayake
A.N.I. Perumal
Affiliation:
Department of Chemistry, Faculty of Science, University of Colombo, Sri Lanka
Y.I.N.S. Gunawardene
Affiliation:
Molecular Medicine Unit, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka
R.S. Dassanayake*
Affiliation:
Department of Chemistry, Faculty of Science, University of Colombo, Sri Lanka
*
*Fax: 94-11-2503367 E-mail: rsdassanayake@chem.cmb.ac.lk
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Abstract

Setaria digitata is a filarial parasite that causes fatal cerebrospinal nematodiasis in goats, sheep and horses, resulting in substantial economic losses in animal husbandry in the tropics. Due to its close resemblance to Wuchereria bancrofti, this nematode is also frequently used as a model organism to study human lymphatic filariasis. This review highlights numerous insights into the morphological, histological, biochemical, immunological and genetic aspects of S. digitata that have broadened our understanding towards the control and eradication of filarial diseases.

Type
Review Article
Information
Journal of Helminthology , Volume 90 , Issue 2 , March 2016 , pp. 129 - 138
Copyright
Copyright © Cambridge University Press 2015 

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References

Abhilashkumar, R., Mohan, S., Jayakumar, K. & Raj, R.K. (2001) Functional importance of the different ubiquinones in the filarial parasite Setaria digitata . Biochemical and Biophysical Research Communications 283, 938–942.Google Scholar
Ambroise-thomas, P. (1974) Immunological diagnosis of human filariases: present possibilities, difficulties and limitations [a review]. Acta Tropica 31, 109–128.Google Scholar
Babu, S. & Nutman, T.B. (2012) Immunopathogenesis of lymphatic filarial disease. Seminars in Immunopathology 34, 847–861.Google Scholar
Bal, M. & Das, M.K. (1996) Glutathione-binding proteins of Setaria digitata: antibody responses in human infected with Wuchereria bancrofti . Parasite Immunology 18, 473–477.Google Scholar
Banu, M.J., Nellaiappan, K. & Dhandayuthapani, S. (1989) Lactate dehydrogenase from adult Setaria digitata (Nematoda: Onchocercidae). Veterinary Parasitology 32, 311–323.Google Scholar
Banu, M.J., Kalyani, R. & Nellaiappan, K. (1990) Some properties of β-D-galactosidase from the adult filarial nematode Setaria digitata . Veterinary Parasitology 36, 27–36.Google Scholar
Banu, M.J., Dhandayuthapani, S. & Nellaiappan, K. (1991) Intermediary carbohydrate metabolism in the adult filarial worm Setaria digitata . International Journal for Parasitology 21, 795–799.Google Scholar
Banu, M.J., Nellaiappan, K. & Dhandayuthapani, S. (1992) Mitochondrial malate dehydrogenase and malic enzyme of a filarial worm Setaria digitata: some properties and effects of drugs and herbal extracts. Japanese Journal of Medical Science and Biology 45, 137–150.Google Scholar
Bazargani, T., Eslami, A., Gholami, G.R., Molai, A., Ghafari-Charati, J., Dawoodi, J. & Ashrafi, J. (2008) Cerebrospinal nematodiasis of cattle, sheep and goats in Iran. Iranian Journal of Parasitology 3, 16–20.Google Scholar
Beuria, M.K. & Das, M.K. (1992) Immune response to an allergenic fraction of Setaria digitata in human filariasis. Journal of Biosciences 17, 453–461.Google Scholar
Bright, J.J. & Raj, R.K. (1994) Ontogenetic transformation of surface epitope expression, an adaptive immunoevasive strategy of filarial parasites. Indian Journal of Experimental Biology 32, 49–54.Google Scholar
Dalai, S.K., Das, D. & Kar, S.K. (1998) Setaria digitata adult 14- to 20-kDa antigens induce differential Thl/Th2 cytokine responses in the lymphocytes of endemic normals and asymptomatic microfilariae carriers in bancroftian filariasis. Journal of Clinical Immunology 18, 114–123.CrossRefGoogle Scholar
Dassanayake, R.S., Rodrigo, W.W.P., Karunanayake, E.H., Weerasena, O.V.D.S.J. & Chandrasekharan, N.V. (2009) A putative nuclear growth factor-like globular nematode specific protein. Bioinformation 3, 370–374.CrossRefGoogle ScholarPubMed
Decruse, S.W. & Raj, R.K. (1988) Excretory secretory material from different sites of female reproductive tissue of filarial parasite Setaria digitata . Indian Journal of Experimental Biology 26, 781–783.Google Scholar
Decruse, S.W. & Raj, R.K. (1990) Histological studies on female Setaria digitata (von Linstow 1906), a filaria of bovine, Bos indicus . Proceedings of the Indian Academy of Sciences (Animal Sciences) 99, 103–112.Google Scholar
Decruse, S.W. & Raj, R.K. (1992) Cytology and sex determination of Setaria digitata (von Linstow 1906) a bovine filarial parasite (Nematoda: Filarioidea). Cytologia 57, 511–514.Google Scholar
Dissanayake, S. & Ismail, M.M. (1980) Antigens of Setaria digitata: Cross-reaction with surface antigens of Wuchereria bancrofti microfilariae and serum antibodies of W. bancrofti-infected subjects. Bulletin of the World Health Organization 58, 649–654.Google Scholar
Dissanayake, S. & Ismail, M.M. (1981) Antibody determination in the diagnosis of Wuchereria bancrofti infection in man. Bulletin of the World Health Organization 59, 753–757.Google Scholar
Dissanayake, S. & Jayasekera, N. (1989) Bancroftian filariasis in Sri Lanka: an overview of current knowledge. Journal of the National Science Council of Sri Lanka 17, 141–160.Google Scholar
Dissanayake, S., Galahitiyawa, S.C. & Ismail, M.M. (1982) Immune complexes in Wuchereria banchrofti infection in man. Bulletin of the World Health Organization 60, 919–927.Google Scholar
Eamsobhana, P., Lim, P.-E. & Yong, H.S. (2013) Molecular phylogeny of filarial worms (Nematoda: Filarioidea). The Raffles Bulletin of Zoology 29, 99–109.Google Scholar
Gupta, S. & Srivastava, A.K. (2005) Biochemical targets in filarial worms for selective antifilarial drug design. Acta Parasitologica 50, 1–18.Google Scholar
Harinath, B.C. (1984) Immunodiagnosis of bancroftian filariasis–problems and progress. Journal of Biosciences 6, 691–699.Google Scholar
Innes, J.R.M. & Shoho, C. (1952) Nematodes, nervous disease, and neurotropic virus infection: observations in animal pathology of probable significance in medical neurology. British Medical Journal 2, (4780), 366–368.Google Scholar
Jayasena, S.M.T., Chandrasekharan, N.V. & Karunanayake, E.H. (1999) Molecular characterisation of a hsp70 gene from the filarial parasite Setaria digitata . International Journal for Parasitology 29, 581–591.Google Scholar
John, L., Bright, J.J. & Raj, R.K. (1995) Biological activity and diagnostic use of detergent soluble antigens from Setaria digitata . Journal of Biosciences 20, 69–81.Google Scholar
Kalyanasundaram, M., Mathew, N., Paily, K.P. & Prabakaran, G. (2009) Synthesis and screening of 1-methyl-4-substituted benzoyl piperazides against adult Setaria digitata for antifilarial activity. Acta Tropica 111, 168–171.Google Scholar
Keiser, P.B. & Nutman, T.B. (2002) Update on lymphatic filarial infections. Current Infectious Disease Reports 4, 65–69.Google Scholar
Kim, N.S., Kim, H.C., Sim, C., Ji, J.R. & Park, B.K. (2010) Congenital infection with Setaria digitata and Setaria marshalli in the thoracic cavity of a Korean calf: a case report. Veterinarni Medicina 55, 275–280.Google Scholar
Kumar, R.A. & Raj, R.K. (1998) Presence and formation of heme and occurrence of certain heme proteins in the filarial parasite Setaria digitata . Biochemical and Biophysical Research Communications 253, 49–52.Google Scholar
Kumari, G.A., Santhamma, K.R. & Raj, R.K. (1994) Biosynthesis of isoprenoid compounds in cattle filarial parasite Setaria digitata . Biochemical and Biophysical Research Communications 205, 24–29.Google Scholar
Liang-Sheng, Y. (1959) A revision of the nematode genus Setaria Viborg, 1795, its host–parasite relationship, speciation and evolution. Journal of Helminthology 33, 1–98.Google Scholar
Madathiparambil, M.G., Kaleysa, K.N. & Raghavan, K. (2009) A diagnostically useful 200-kDa protein is secreted through the surface pores of the filarial parasite Setaria digitata . Parasitology Research 105, 1099–1104.Google Scholar
Madathiparambil, M.G., Kavitha Raj, N.K., Linda, J. & Kaleysa Raj, R. (2011) Surface of the filarial parasite Setaria digitata and the structural changes on treatment with Triton X-100. Helminthologia 48, 17–22.Google Scholar
McNulty, S.N., Mullin, A.S., Vaughan, J.A., Tkach, V.V., Weil, G.J. & Fischer, P.U. (2012) Comparing the mitochondrial genomes of Wolbachia-dependent and independent filarial nematode species. BMC Genomics 13, 145.Google Scholar
Mohanty, M.C., Satapathy, A.K., Sahoo, P.K. & Ravindran, B. (2001) Human bancroftian filariasis–a role for antibodies to parasite carbohydrates. Clinical and Experimental Immunology 124, 54–61.Google Scholar
Murugananthan, A., Karunanayake, E.H. & Tennekoon, K.H. (2010) Cloning and characterisation of alkali myosin light chain gene (MLC-3) of cattle filarial parasite Setaria digitata . Institute of Integrative Omics and Applied Biotechnology Journal 1, 1–10.Google Scholar
Muthian, G., Pradeep, C.G., Sargapradeep, K., Kaleysaraj, R. & Bright, J.J. (2006) Setaria digitata secreted filarial lipids modulate IL-12 signaling through JAK-STAT pathway leading to the development of Th1 response. Experimental Parasitology 114, 193–203.Google Scholar
Nagaratnam, N., Karunanayake, E.H., Tennekoon, K.H., Samarakoon, S.R. & Mayan, K. (2014) In silico characterization of a RNA binding protein of cattle filarial parasite Setaria digitata . Bioinformation 10, 512–517.Google Scholar
Ojiako, O.A. & Onyeze, G.O.C. (2009) Epidemiological and biochemical studies of human lymphatic filariasis and associated parasitoses in Oguta, South-Eastern, Nigeria. African Journal of Biochemistry Research 3, 114–119.Google Scholar
Rafi, M.M. & Raj, R.K. (1991) Phosphoenolpyruvate-succinate-glyoxylate pathway in the filarial parasite Setaria digitata . Journal of Biosciences 16, 121–126.Google Scholar
Raj, R.K., Puranam, R.S., Kurup, C.K.R. & Ramasarma, T. (1988) Oxidative activities in mitochondria-like particles from Setaria digitata, a filarial parasite. Biochemical Journal 256, 559–564.Google Scholar
Raj, R.K., Pradeep, C.G., Devi, C.M., John, L., Rekha, M.R. & OOmmen, S.K. (1997) Immunomodulation of excretory secretory materials from the filarial parasite Setaria digitata . Indian Journal of Clinical Biochemistry 12, 32–34.Google Scholar
Rhee, J.K., Choi, E.Y., Park, B.K. & Jang, B.G. (1994) Application of scanning electron microscopy in assessing the prevalence of some Setaria species in Korean cattle. Korean Journal of Parasitology 32, 1–6.Google Scholar
Rodrigo, W.W., Dassanayake, R.S., Weerasena, S.J. & Silva Gunawardene, Y.I. (2014a) Novel parasitic nematode-specific protein of bovine filarial parasite Setaria digitata displays conserved gene structure and ubiquitous expression. Tropical Biomedicine 31, 514–524.Google Scholar
Rodrigo, W.W.P., Dassanayake, R.S., Karunanayake, E.H., Silva Gunawardene, Y.I.N. & Weerasena, O.V.D.S.J. (2014b) Heterologous expression, chaperone mediated solubilization and purification of parasitic nematode-specific growth factor-like protein of Setaria digitata . Asian Pacific Journal of Tropical Medicine 7, 85–92.Google Scholar
Rodrigo, W.W.P., Dassanayake, R.S. & Voronin, D. (2014c) Novel parasitic nematode-specific protein of Setaria digitata largely localized in longitudinal muscles, reproductive systems and developing embryos. Experimental Parasitology 141, 12–20.CrossRefGoogle ScholarPubMed
Sahu, B.R., Mohapatra, A.D., Majumder, A., Das, P.K. & Ravindran, B. (2005) A flow cytometry based method for studying embryogenesis and immune reactivity to embryogenic stages in filarial parasites. Filaria Journal 4, 1–11.Google Scholar
Sahu, B.R., Mohanty, M.C., Sahoo, P.K., Satapathy, A.K. & Ravindran, B. (2008) Protective immunity in human filariasis: a role for parasite-specific IgA responses. Journal of Infectious Diseases 198, 434–443.Google Scholar
Santhamma, K.R. & Raj, R.K. (1990) Quinone mediated ATP production in the filarial parasite Setaria digitata . Biochemical and Biophysical Research Communications 167, 568–574.Google Scholar
Sasisekhar, B., Suba, N., Sindhuja, S., Sofi, G.M.A. & Narayanan, R.B. (2005) Setaria digitata: identification and characterization of a hypodermally expressed SXP/RAL2 protein. Experimental Parasitology 111, 121–125.Google Scholar
Sivan, V.M. & Raj, R.K. (1992) Quinine dependent NADH dehydrogenation in mitochondria-like particles from Setaria digitata, a filarial parasite. Biochemical and Biophysical Research Communications 186, 698–705.Google Scholar
Sivan, V.M. & Raj, R.K. (1994) Lactate oxidation coupled to energy production in mitochondria-like particles from Setaria digitata, a filarial parasite. Biochemical and Biophysical Research Communications 204, 17–22.Google Scholar
Srinivasan, L., Mathew, N., Karunan, T. & Muthuswamy, K. (2011) Biochemical studies on glutathione S-transferase from the bovine filarial worm Setaria digitata . Parasitology Research 109, 213–219.Google Scholar
Strubing, U., Lucius, R., Hoerauf, A. & Pfarr, K.M. (2010) Mitochondrial genes for heme-dependent respiratory chain complexes are up-regulated after depletion of Wolbachia from filarial nematodes. International Journal for Parasitology 40, 1193–1202.Google Scholar
Theodore, J.G. & Kaliraj, P. (2009) Isolation, purification and characterization of surface antigens of the bovine filarial parasite Setaria digitata for the immunodiagnosis of bancroftian filariasis. Journal of Helminthology 64, 105–114.Google Scholar
Tung, K.C., Cheng, F.P., Lai, C.H., Wang, K.S., Wang, J.S. & Lee, W.M. (2004) Demonstration of vector competence of Culex quinquefasciatus (Diptera: Culicidae) for Setaria digitata . Veterinary Parasitology 123, 279–284.Google Scholar
Unnikrishnan, L.S. & Raj, R.K. (1992) Fumarate reductase system of filarial parasite Setaria digitata . Biochemical and Biophysical Research Communications 184, 448–453.Google Scholar
Unnikrishnan, L.S. & Raj, R.K. (1995) Transhydrogenase activities and malate dismutation liked to fumarate reductase system in the filarial parasite Setaria digitata . International Journal for Parasitology 25, 779–785.Google Scholar
Verma, S.K., Bansal, I., Vedi, S., Saxena, J.K., Katoch, V.M. & Bhattacharya, S.M. (2008) Molecular cloning, purification and characterisation of myosin of human lymphatic filarial parasite Brugia malayi . Parasitology Research 102, 481–489.Google Scholar
Voronin, D., Abeykoon, A.M.L.L., Gunawardene, Y.I.S. & Dassanayake, R.S. (2015) Absence of Wolbachia endobacteria in Sri Lankan isolates of the nematode parasite of animals Setaria digitata . Journal of Veterinary Parasitology 207, 350–354.Google Scholar
Wickremanayake, M.N., Ekanayake, S. & Karunanayake, E.H. (2001) Wuchereria bancrofti: detection of microfilariae in asymptomatic microfilaremic individuals with Setaria digitata antigens. Southeast Asian Journal of Tropical Medicine and Public Health 32, 230–234.Google Scholar
Wijesundera, W.S.S., Chandrasekharan, N.V., Karunanayake, E.H. & Dharmasena, S.P. (1996) Development of a diagnostic DNA probe to detect Setaria digitata: the causative parasite of cerebrospinal nematodiasis in goats, sheep and horses. British Veterinary Journal 152, 561–571.Google Scholar
World Health Organization. (2013) Lymphatic filariasis: Managing morbidity and preventing disability: an aide-memoire for national programme managers. pp. 1–53. Geneva, World Health Organization.Google Scholar
Yatawara, L., Wickramasinghe, S., Rajapakse, R.P.V.J. & Agatsuma, T. (2010) The complete mitochondrial genome of Setaria digitata (Nematoda: Filarioidea): mitochondrial gene content, arrangement and composition compared with other nematodes. Molecular and Biochemical Parasitology 173, 32–38.Google Scholar