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Tests with a new compound (Praziquantel) against Diphyllobothrium latum

Published online by Cambridge University Press:  05 June 2009

G. Bylund ,
B. Bång  and
K. Wikgren
G. Bylund
Affiliation:
Parasitological Institute, Åbo Akademi, Åbo, Finland
B. Bång
Affiliation:
Parasitological Institute, Åbo Akademi, Åbo, Finland
K. Wikgren
Affiliation:
Parasitological Institute, Åbo Akademi, Åbo, Finland
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Abstract

Praziquantel (Droncit) is a new anthelminthic agent with a strikingly wide therapeutic index. The efficiency of the drug against Diphyllobothrium latum was tested in vivo and in vitro. With a drug dose of 50 mg/kg, artificially infected hamsters were completely cured. The threshold value of the active dose was between 2·5 and 10·0 mg/kg. Clinical trials with Praziquantel against human diphyllobothriasis show great promise, all of ten patients treated with 25·0 mg/kg of the drug being cured. Praziquantel had little effect on larval or adult diphyllobothriids in vitro.

Type
Research Article
Information
Journal of Helminthology , Volume 51 , Issue 2 , June 1977 , pp. 115 - 119
Copyright
Copyright © Cambridge University Press 1977

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References

REFERENCES

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