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An evaluation of mucus glycoproteins in the larynges of victims of sudden infant death syndrome

Published online by Cambridge University Press:  29 June 2007

Christine A. Brock
Christine A. Brock*
Affiliation:
Department of Comparative Anatomy, The Institute of Laryngology and Otology, 330-332 Gray's Inn Road, London WC1X 8EE.
*
Address for correspondence: Ms C. A. Brock, Department of Comparative Anatomy, The Institute of Laryngology and Otology, 330-332 Gray's Inn Road, London WCIX 8EE. FAX: 0171-837-9279
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Abstract

Larynges from 24 victims of Sudden Infant Death Syndrome (.S.I.D.S.) and 10 controls, with ages ranging from two days to 24 weeks in the controls and from two toN 16 weeks in theS.1.D.S. victims, were transversely, step-serially sectioned and then stained to show acid, neutral and mixed mucus glycoproteins

The proportion of sulphated mucus glycoprotein and sialylated mucus glycoprotein to total acid mucus glycoprotein was determined by the use of various staining techniques and a comparison was made for each type between S.I.D.S. and controls. The differences were significant with a mean of 27 per cent in the controls compared to 59 per cent in the S.I.D.S. for sulphomucin (difference 32 per cent; standard error of difference 6 per cent; p<0.01) and 73 per cent in the controls compared to 41 per cent in the S.I.D.S. larynges (difference 32 per cent; standard error of difference six per cent; p<0.01) for sialomucin. The results suggest that sulphated mucus glycoprotein is secreted in excess in some victims of Sudden Infant Death Syndrome.

Keywords

Sudden infant deathLarynxMucins
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 109 , Issue 5 , May 1995 , pp. 403 - 409
Copyright
Copyright © JLO (1984) Limited 1995

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References

Berry, C. N., Lloyd, K. G., Louisot, P. (1992) Effects of Scarboxymethyl-L-cysteine on pulmonary sialyl transferase activity in vitro in healthy and in sulphur-dioxide-induced bronchitic rats. Fundamentals and Clinical Pharmacology 6: 29–35.CrossRefGoogle ScholarPubMed
Coles, S. J., Levine, L. R., Reid, L. (1979) Hypersecretion of mucus glycoproteins in rat airways induced by tobacco smoke. American Journal of Pathology 94: 459–472.Google ScholarPubMed
Downing, S. E., Lee, J. C. (1975) Laryngeal chemosensitivity. A possible mechanism for sudden infant death. Pediatrics 55(5): 640–649.CrossRefGoogle ScholarPubMed
Fink, B. R., Beckwith, B. (1980) Laryngeal mucous gland excess in victims of sudden infant death. American Journal of Diseases in Childhood 134: 144–146.Google ScholarPubMed
Harrison, D. F. (1991 a) Histologic evaluation of the larynx in sudden infant death syndrome. Annals of Otology, Rhinology and Laryngology 100: 173–175.CrossRefGoogle ScholarPubMed
Harrison, D. F. (1991 b) Laryngeal morphology in sudden unexpected death in infants. Journal of Laryngology and Otology 105: 646–650.CrossRefGoogle ScholarPubMed
Hayashi, M. D., Sornberger, G. C., Huber, G. L. (1980) A morphometric analysis of the male and female tracheal epithelium after experimental exposure to marijuana smoke. Laboratory Investigation 42 (1): 65–69.Google Scholar
Jany, B., Basbaum, C. B. (1991) Mucin in disease: modification of mucin gene expression in airway disease. American Review of Respiratory Disease 144: 538–541.CrossRefGoogle ScholarPubMed
Jeffery, H. E., Rahilly, P., Read, D. J. (1983) Multiple causes of asphyxia in infants at high risk for sudden infant death. Archives of Disease in Childhood 58: 92–100.CrossRefGoogle ScholarPubMed
Jefferey, P. K., Reid, L. M. (1977) The respiratory mucous membrane. In Respiratory Defense Mechanisms. Part 1. (Brain, J. D., Proctor, D. E., Reid, L. M., eds.), Marcel Decker, New York, pp 193–245.Google Scholar
Jones, R., Reid, L. (1978) Secretory cells and their glycoproteins in health and disease. British Medical Bulletin 341, 9–16.CrossRefGoogle Scholar
Jones, S., Bolduc, P., Reid, L. (1972) Protection of rat epithelium against tobacco smoke. British Medical Journal 2: 142–144.CrossRefGoogle ScholarPubMed
Lamb, D. (1969) Intracellular development and secretion of mucus in the normal and morbid bronchial tree. Ph.D. Thesis, London University.Google Scholar
Lamb, D., Reid, L. (1968) Mitotic rates, goblet cell increase and histochemical changes in mucus in rat bronchial epithelium during exposure to sulphur dioxide. Journal of Pathology and Bacteriology 96: 97–111.CrossRefGoogle ScholarPubMed
Lamb, D., Reid, L. (1972) Acidic glycoproteins produced by the mucous cells of the bronchial submucosal glands in the fetus and child: a histochemical and autoradiographic study. British Journal of Diseases of the Chest 66: 248–253.CrossRefGoogle Scholar
Lamblin, G., Lhermitte, L., Klein, A., Houdret, N., Scharfman, A., Ramphal, R., Roussel, P. (1991) The carbohydrate diversity of human respiratory mucins: a protection of the underlying mucosa American Review of Respiratory Disease; Airway Mucin 144: 519–524.Google ScholarPubMed
Nassar, V., Bridger, G. (1971) Topography of the laryngeal mucous glands. Archives of Otolaryngology 94: 490–498.CrossRefGoogle ScholarPubMed
Peterson, D. (1989) The epidemiology of Sudden Infant Death Syndrome. In Sudden Infant Death Syndrome Medical Aspects and Psychological Management. (Cuthbertson, J., Krous, H., Bendell, R., eds.), E. Arnold of Hodder and Stoughton Ltd, London, pp 3–17.Google Scholar
Reid, L. (1977) Anatomic and pathophysiologic factors in infections of the airways and pulmonary parenchyma in infants and children: influence of the pattern of structural growth of lung on susceptibility to specific infectious diseases in infants and children. Pediatric Research 11: 210–215.Google Scholar
Reid, L., de Hailer, R. (1967) Clinical investigations on cystic fibrosis. The bronchial mucous glands-their hypertrophy and change in intracellular mucus. Modern Problems in Paediatrics 10: 195–199.Google Scholar
Scott, D. J., Gardener, P. S.McQuillen, J., Stanton, A. N., Downham, M. A. S. (1978) Respiratory viruses and cot death. British Medical Journal 2: 12–13.CrossRefGoogle ScholarPubMed
Sheehan, J., Thornton, D., Somerville, M., Carlstedt, I. (1991) Mucin structure. The structure and heterogeneity of respiratory mucus glycoproteins American Review of Respiratory Disease 144: 54–59.Google ScholarPubMed
Spicer, S. S., Schulte, B. A., Charkin, L. W. (1983) Ultrastructural and histochemical observations of respiratory epithelium and gland. Experimental Lung Research 4: 137–156.CrossRefGoogle ScholarPubMed
Wedgewood, R. J., Benditt, E. P. (eds.) (1963) Sudden Death in Infants, Proceedings of the Conference on Causes of Sudden Death in Infants, USA Public Health Service Publication, No. 1412.Google Scholar
Williams, A. L. (1980) Tracheobronchitis and sudden infant death syndrome. Pathology 12: 73–78.CrossRefGoogle ScholarPubMed
Williams, A. L., Uren, E., Bretherton, L. (1984) Respiratory viruses and sudden infant death. British Medical Journal 288: 1491–1493.CrossRefGoogle ScholarPubMed