Hostname: page-component-586b7cd67f-tf8b9 Total loading time: 0 Render date: 2024-11-23T07:28:48.008Z Has data issue: false hasContentIssue false
  • English
  • Français

Anti-neutrophil cytoplasmic antibody-associated mucocutaneous allergic vasculitis with oral manifestations caused by propylthiouracil

Published online by Cambridge University Press:  29 June 2007

M. M. Sorribes ,
N. R. Welinder  and
S.-E. Stangerup
M. M. Sorribes*
Affiliation:
Department of Otorhinolaryngology, Gentofte University Hospital, DK-2900 Hellerup, Denmark.
N. R. Welinder
Affiliation:
Department of Otorhinolaryngology, Gentofte University Hospital, DK-2900 Hellerup, Denmark.
S.-E. Stangerup
Affiliation:
Department of Otorhinolaryngology, Gentofte University Hospital, DK-2900 Hellerup, Denmark.
*
Address for correspondence: Michael M. Sorribes, The Department of Otorhinolaryngology, Hillerød Hospital, Dyrehavevej 2, DK-3400 Hillerød, Denmark. Fax: +45 48 29 38 11
Get access Rights & Permissions [Opens in a new window]

Abstract

A 49-year-old woman treated with increasing dosage of propylthiouracil (PTU) in order to control hyperthyroidism, developed progressive necrotic ulcers in the oral cavity, oropharynx and rhinopharynx and vasculitic ulcers on both auricular pinnae after a few days. The PTU treatment was immediately discontinued and the mucosal and skin manifestations resolved promptly. Laboratory findings, including anti-neutrophil cytoplasmic antibodies (ANCA), suggested allergic vasculitis. This is to our knowledge the first reported case of oral manifestations of PTU-induced allergic vasculitis.

Keywords

Vasculitis, allergic cutaneousOral ulcerDrug therapyAntibodies, antineutrophil cytoplasmic
Type
Clinical Records
Information
The Journal of Laryngology & Otology , Volume 113 , Issue 5 , May 1999 , pp. 477 - 479
Copyright
Copyright © JLO (1984) Limited 1999

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Dolman, K. M., Gans, R. O. B., Vervaat, T. J., Zevenbergen, G., Maingay, D., Nikkels, R. E., Dunker, A. M. J., Borne von dem, A. E. G. K., Goldschmeding, R. (1993) Vasculitis and antineutrophil cytoplasmic autoantibodies associated with propylthiouracil therapy. Lancet 342: 651–652.CrossRefGoogle ScholarPubMed
Tanemoto, M., Miyakawa, H., Harai, J., Yago, M., Kitaoka, M., Uchida, S. (1995) Myeloperioxidase-antineutrophil cytoplasmic antibody positive crescentic glomerulonephritis complicating the cause of Graves disease: report of three adult cases. American Journal of Kidney Diseases 26(5): 774–778.CrossRefGoogle ScholarPubMed
Vasily, D. B., Tyler, W. B. (1980) Propylthiouracil-induced cutaneous vasculitis. Journal of American Medical Association 243: 458–461.CrossRefGoogle ScholarPubMed
Wing, S. S., Fantus, I. G. (1987) Adverse immunologic effects of antithyroid drugs. Canadian Medical Association Journal (Toronto) 136(2): 121–127.Google ScholarPubMed
Yuasa, S., Hashimoto, M., Yura, T., Sumikura, T., Takahashi, N., Shoji, T., Uchida, K., Fujioka, H., Kihara, M., Matsuo, H. (1996) Antineutrophil cytoplasmatic antibodies (ANCA)-associated crescentic glomerulonephritis and propylthiouracil therapy. Nephron 73(4): 701–703.CrossRefGoogle Scholar