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Cephazolin and metronidazole prophylaxis in head and neck surgery

Published online by Cambridge University Press:  29 June 2007

Melvin Strauss ,
Phillip W. Saccogna  and
Allan L. Allphin
Melvin Strauss*
Affiliation:
Department of Otolaryngology–Head and Neck SurgeryCase Western Reserve University School of Medicine, Cleveland, Ohio.
Phillip W. Saccogna
Affiliation:
Department of Easley Head and Neck Surgery, Easley, South Carolina.
Allan L. Allphin
Affiliation:
Department of Regional ENT Center, Springfield, USA.
*
Adress for correspondence: Melvin Strauss, M.D., University Hospitals of Cleveland, 2074 Abington Road, Cleveland, Ohio, 44106, USA.
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Abstract

A seven-day course of cephazolin and metronidazole chemoprophylaxis for clean-contaminated head and neck oncological procedures is compared to results with previously published antibiotic regimens. Aetiological factors associated with increased rates of wound complications are analyzed. Retrospective analysis of procedures over asix-year period was performed. The overall wound complication rate was 28.1 per cent, comparing favourably with previously published results. A major fistula was the most common complication with a rate of 9.2 per cent. Factors statistically associated with increased rates of wound complications included: radical neck dissection, extended surgical procedures requiring flap reconstruction, previous tracheotomy, and race. This is the largest single institutional study to show thata seven-day course of cephazolin and metronidazole is an effective chemoprophylactic regimen in head and neck surgery.

Keywords

AntibioticsWound infectionSurgeryHead and neck neoplasms
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 111 , Issue 7 , July 1997 , pp. 631 - 634
Copyright
Copyright © JLO (1984) Limited 1997

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Footnotes

Presented at the Middle Section Meeting of the Triological Society, Omaha, NE, 22 January 1995.

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