Hostname: page-component-78c5997874-ndw9j Total loading time: 0 Render date: 2024-11-12T21:54:31.673Z Has data issue: false hasContentIssue false
  • English
  • Français

Ear, nose and throat manifestations of Behçet's disease: a review

Published online by Cambridge University Press:  11 July 2008

C J Webb ,
R J Moots  and
A C Swift
C J Webb
Affiliation:
Department of Otorhinolaryngology, Royal Liverpool and Broadgreen University Hospital, Liverpool, UK
R J Moots
Affiliation:
Department of Rheumatology, Head and Neck Surgery, University Hospital Aintree, Liverpool, UK
A C Swift*
Affiliation:
Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Aintree, Liverpool, UK
*
Address for correspondence: Mr A C Swift, Department of Otorhinolaryngology – Head and Neck Surgery, University Hospital Aintree, Lower Lane, Fazakerley, Liverpool L9 7AL, UK. Fax: +44 (0)151 529 5263 E-mail: Andrew_swift@yahoo.com
Get access Rights & Permissions [Opens in a new window]

Abstract

Objective:

To review Behçet's disease and to describe its clinical features in the head, neck and upper respiratory tract.

Method:

A literature review was undertaken, following a Medline search of publications over a 30-year period, and utilising the expert knowledge of one of the authors (RJM) with a specialist interest in Behçet's disease.

Results:

Twenty-seven articles with ENT relevance were obtained. Otorhinolaryngological manifestations included symptoms and signs in the mouth, nose, sinus, larynx and ear.

Conclusion:

Behçet's disease is usually considered to be a condition affecting the oral cavity, eyes and genitals. This article shows that most patients will also exhibit other ENT symptoms, hearing loss in particular. Indeed, Behçet's disease may present with features other than the classic triad of symptoms. Raised awareness of the clinical features within the head and neck region will hopefully enable early diagnosis and treatment of this potentially serious condition.

Keywords

Behçet's DiseaseOtorhinolaryngological DiseasesOtolaryngology
Type
Review Articles
Information
The Journal of Laryngology & Otology , Volume 122 , Issue 12 , December 2008 , pp. 1279 - 1283
Copyright
Copyright © JLO (1984) Limited 2008

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1Dilsen, N. History and development of Behçet's disease. Rev Rhum Engl Ed 1996;63:512–19Google ScholarPubMed
2Verity, CH, Wallace, GR, Vaughan, RW, Stanford, MR. Behçet's disease: from Hippocrates to the third millennium. Br J Ophthalmol 2003;87:1175–83CrossRefGoogle Scholar
3Behçet's disease. http://www.emedicine.com/DERM/topic49.htm [22 August 2005]Google Scholar
4Bang, D, Lee, JH, Lee, E-S, Lee, S, Choi, JS, Kim, YK et al. Epidemiologic and clinical survey of Behçet's disease in Korea: the first multicenter study. J Korean Med Sci 2001;16:615–18CrossRefGoogle ScholarPubMed
5Mege, JL, Dilsen, N, Sanguedolce, V, Gul, A, Bongrand, P, Roux, H et al. Overproduction of monocyte derived TNF, interleukin (IL) 6, IL 8 and increased neutrophil superoxide generation in Behçet's disease. A comparative study with familial Mediterranean fever and healthy subjects. J Rheumatol 1993;20:1544–9Google ScholarPubMed
6Accardo-Palumbo, A, Triolo, G, Carbone, MC, Ferrante, A, Ciccia, F, Giardina, E et al. Polymorphonuclear leukocyte myeloperoxidase levels in Behçet's disease. Clin Exp Rheumatol 2000;18:495–8Google ScholarPubMed
7Gul, A, Inanc, M, Ocal, L, Aral, O, Konice, M. Familial aggregation of Behçet's disease in Turkey. Ann Rheum Dis 2000;59:622–5CrossRefGoogle ScholarPubMed
8Fresko, I, Soy, M, Hamurydan, V, Yurdakul, S, Yavuz, S, Turner, Z et al. Genetic anticipation in Behçet's syndrome. Ann Rheum Dis 1998;57:45–8CrossRefGoogle ScholarPubMed
9Mingari, MC, Moretta, A, Moretta, L. Regulation of KIR expression in human T cells; a safety mechanism that may impair protective T cell responses. Immunol Today 1998;19:153–7CrossRefGoogle Scholar
10Soylu, L, Aydogan, B, Soylu, M, Ozsahinoglu, C. Hearing loss in Behçet's disease. Ann Otol Rhinol Laryngol 1995;104:864–7CrossRefGoogle ScholarPubMed
11Gemignani, G, Berrettini, S, Bruschini, P, Sellari-Francheschini, S, Fusari, P, Piragine, F et al. Hearing and vestibular disturbance in Behçet's syndrome. Ann Otol Rhinol Laryngol 1991;100:459–63CrossRefGoogle ScholarPubMed
12Evereklioglu, C, Cokkeser, Y, Doganay, S, Er, H, Kizilay, A. Audio-vestibular evaluation in patients with Behçet's syndrome. J Laryngol Otol 2001;115:704–8CrossRefGoogle ScholarPubMed
13Martins, HM, Santos, S, Lourenco, JF, Araujo, JA. Destructive sinusopathy and middle ear involvement in Behçet's syndrome. A case report. Adv Exp Med Biol 2003;528:473–5CrossRefGoogle ScholarPubMed
14Shahram, F, Assadi, K, Davatchi, F, Nadji, A, Jamshidi, A, Chams, C et al. Chronology of clinical manifestations in Behçet's disease. Analysis of 4024 cases. Adv Exp Med Biol 2003;528:85–9CrossRefGoogle ScholarPubMed
15Papadimitraki, ED, Kyrmizakis, DE, Kritikos, I, Boumpas, DT. Ear-nose-throat manifestations of autoimmune rheumatic diseases. Clin Exp Rheumatol 2004;22:485–94Google ScholarPubMed
16Nonomura, N, Nishiwaki, C, Hasegawa, S, Ikarashi, F, Nakano, Y. A case of pharyngolaryngeal stenosis in Behçet's disease. Auris Nasus Larynx 1992;19:55–61CrossRefGoogle ScholarPubMed
17Brookes, GB. Pharyngeal stenosis in Behçet's disease. The first reported case. Arch Otolaryngol 1983;109:338–40CrossRefGoogle Scholar
18Hamza, M, Ferjaoui, M, Elleuch, M, Bergaoui, N, Souilem, J, Atallah, M et al. Pharyngeal stenosis in a case of Behçet's disease [in French]. Ann Otolaryngol Chir Cervicofac 1985;102:465–7Google Scholar
19Hamza, M. Pharyngeal stenosis in Behçet's disease. Clin Exp Rheumatol 1988;6:139–40Google ScholarPubMed
20Bang, D. Clinical spectrum of Behçet's disease. J Dermatol 2001;28:610–13CrossRefGoogle ScholarPubMed
21Yazici, H, Tuzun, Y, Pazarli, H, Yalcin, B, Yurdakul, S, Muftuoglu, A. The combined use of HLA-B5 and the pathergy test as diagnostic markers of Behçet's disease in Turkey. J Rheumatol 1980;7:206–10Google ScholarPubMed
22Davies, PG, Fordham, JN, Kirwan, JR, Barnes, CG, Dinning, WJ. The pathergy test and Behçet's syndrome in Britain. Ann Rheum Dis 1984;43:70–3CrossRefGoogle ScholarPubMed
23Yazici, H, Chamberlain, MA, Tuzun, Y, Yurdakul, S, Muftuoglu, A. A comparative study of the pathergy reaction among Turkish and British patients with Behçet's disease. Ann Rheum Dis 1984;43:74–5CrossRefGoogle ScholarPubMed
24International Study Group for Behçet's Disease. Criteria for diagnosis of Behcet's disease. Lancet 1990;335:1078–80Google Scholar
25Mizushima, Y, Inaba, G, Mimura, Y, Ohno, S. Diagnostic criteria for Behçet's disease in 1987 and guidelines for treating Behçet's disease. Saishin Igaku 1988;43:391–3 [in English, later amended in Japanese]Google Scholar
26Rhee, SH, Kim, YB, Lee, ES. Comparison of Behçet's disease and recurrent aphthous ulcer according to characteristics of gastrointestinal symptoms. J Korean Med Sci 2005;20:971–6CrossRefGoogle ScholarPubMed
27Estrach, C, Mpofu, S, Moots, RJ. Behçet's syndrome: response to infliximab after failure of etanercept. Rheumatology 2002;41:1213–14CrossRefGoogle ScholarPubMed