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Effect of early postnatal air-conduction auditory deprivation on the development and function of the rat spiral ganglion

Published online by Cambridge University Press:  13 June 2011

F Wang ,
X Gao ,
J Chen ,
S-L Liu ,
F-Y Wang ,
R-Y Hei ,
Y Chen  and
J-H Qiu
F Wang
Affiliation:
Department of Otolaryngology, General Hospital of Air Force, Beijing, People's Republic of China Department of Otorhinolaryngology, Head and Neck Surgery, Xijing Hospital, The Fourth Military Medical University, Xi'an, Shaanxi, People's Republic of China
X Gao
Affiliation:
Department of Otorhinolaryngology, Head and Neck Surgery, Xijing Hospital, The Fourth Military Medical University, Xi'an, Shaanxi, People's Republic of China Department of Otorhinolaryngology, Head and Neck Surgery, General Hospital of Second Artillery, Beijing, People's Republic of China
J Chen
Affiliation:
Department of Otorhinolaryngology, Head and Neck Surgery, Xijing Hospital, The Fourth Military Medical University, Xi'an, Shaanxi, People's Republic of China
S-L Liu
Affiliation:
Department of Otorhinolaryngology, Head and Neck Surgery, Xijing Hospital, The Fourth Military Medical University, Xi'an, Shaanxi, People's Republic of China
F-Y Wang
Affiliation:
Department of Otorhinolaryngology, Head and Neck Surgery, Xijing Hospital, The Fourth Military Medical University, Xi'an, Shaanxi, People's Republic of China
R-Y Hei
Affiliation:
Department of Otorhinolaryngology, Head and Neck Surgery, Xijing Hospital, The Fourth Military Medical University, Xi'an, Shaanxi, People's Republic of China
Y Chen*
Affiliation:
Department of Otorhinolaryngology, Head and Neck Surgery, Xijing Hospital, The Fourth Military Medical University, Xi'an, Shaanxi, People's Republic of China
J-H Qiu
Affiliation:
Department of Otorhinolaryngology, Head and Neck Surgery, Xijing Hospital, The Fourth Military Medical University, Xi'an, Shaanxi, People's Republic of China
*
Address for correspondence: Dr Yang Chen, Department of Otorhinolaryngology, Head and Neck Surgery, Xijing Hospital, The Fourth Military Medical University, Xi'an, Shaanxi 710032, P R China Fax: +86 29 83224749 E-mail: chendoc@fmmu.edu.cn
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Abstract

Objective:

To evaluate the effect of early postnatal air-conduction auditory deprivation on the development and function of the rat spiral ganglion.

Study design:

Randomised animal study.

Methods:

Sixty neonatal Sprague–Dawley rats were randomly divided into two groups: controls (n = 30) given regular chow and water ad libitum; and study animals (n = 30) fed within a soundproof chamber. Auditory brainstem response testing was conducted in both groups on postnatal day 42.

Results:

Auditory deprivation between postnatal days 12 and 42 resulted in an increased hearing threshold and reduced auditory brainstem response amplitudes, together with degeneration of type I spiral ganglion neurons and the presence of apoptotic cells.

Conclusion:

Non-invasive auditory deprivation during a critical developmental period resulted in numerous changes in rat cochlear function and morphology.

Keywords

CochleaRatsSpiral GanglionSensory DeprivationNeuron-Specific EnolaseHearing
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 125 , Issue 9 , September 2011 , pp. 917 - 923
Copyright
Copyright © JLO (1984) Limited 2011

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