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The effect of local application of insulin-like growth factor for prevention of inner-ear damage caused by electrode trauma

Published online by Cambridge University Press:  26 January 2017

H Gur ,
Y Alimoglu ,
U Duzenli ,
S Korkmaz ,
S Inan  and
L Olgun
H Gur
Affiliation:
Otolaryngology Department, Bozyaka Training and Research Hospital, Izmir, Turkey
Y Alimoglu*
Affiliation:
Otolaryngology Department, Haseki Training and Research Hospital, Istanbul, Turkey
U Duzenli
Affiliation:
Otolaryngology Department, Bozyaka Training and Research Hospital, Izmir, Turkey
S Korkmaz
Affiliation:
Otolaryngology Department, Bozyaka Training and Research Hospital, Izmir, Turkey
S Inan
Affiliation:
Histology Department, Medical Faculty, Celal Bayar University, Manisa, Turkey
L Olgun
Affiliation:
Otolaryngology Department, Bozyaka Training and Research Hospital, Izmir, Turkey
*
Address for correspondence: Dr Yalcin Alimoglu, Otolaryngology Department, Haseki Training and Research Hospital, Istanbul, Turkey E-mail: alimoglu2001@gmail.com
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Abstract

Background:

Electrode insertion during cochlear implantation causes cochlear damage and apoptosis. Insulin-like growth factor applied locally was investigated in 21 rats.

Methods:

In the sham group, an intracochlear dummy electrode was inserted through the round window. In the control group, after the same insertion procedure, saline-soaked porcine skin gelatine was placed on the round window. In the study group, insulin-like growth factor 1 soaked gelatine was placed on the round window. Auditory brainstem response thresholds were measured and histopathological examination was performed.

Results:

In the study group, at 2–4 kHz, one rat had deterioration, one showed improvement and the rest had stable thresholds 14 days after intervention. At 6 kHz, four rats showed improvement and the rest remained stable. At 8 kHz, four showed improvement, one had deterioration and two remained stable. In the other groups, hearing loss deteriorated in about half of the rats and remained stable in the rest. The mean post-operative 6 kHz threshold was significantly lower than that immediately after the intervention in the study group, contrary to the other groups. The study group had significantly better mean histopathological grading than the other groups.

Conclusion:

Local insulin-like growth factor 1 application may protect hearing after cochlear implantation.

Keywords

Insulin-Like Growth FactorApoptosisEar, InnerCochlear Implantation
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 131 , Issue 3 , March 2017 , pp. 245 - 252
Copyright
Copyright © JLO (1984) Limited 2017 

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References

1 Ahmad, FI, Choudhury, B, De Mason, CE, Adunka, OF, Finley, CC, Fitzpatrick, DC. Detection of intracochlear damage during cochlear implant electrode insertion using extracochlear measurements in the gerbil. Laryngoscope 2012;122:636–44Google Scholar
2 Leake, PA, Stakhovskaya, O, Hetherington, A, Rebscher, SJ, Bonham, B. Effects of brain-derived neurotrophic factor (BDNF) and electrical stimulation on survival and function of cochlear spiral ganglion neurons in deafened, developing cats. J Assoc Res Otolaryngol 2013;14:187–211 CrossRefGoogle ScholarPubMed
3 Eastwood, H, Chang, A, Kel, G, Sly, D, Richardson, R, O'Leary, SJ. Round window delivery of dexamethasone ameliorates local and remote hearing loss produced by cochlear implantation into the second turn of the guinea pig cochlea. Hear Res 2010;265:25–9CrossRefGoogle ScholarPubMed
4 Rosenbloom, AL. Mecasermin (recombinant human insulin-like growth factor I). Adv Ther 2009;26:40–54 Google Scholar
5 Nakagawa, T, Sakamoto, T, Hiraumi, H, Kikkawa, YS, Yamamoto, N, Hamaguchi, K et al. Topical insulin-like growth factor 1 treatment using gelatin hydrogels for glucocorticoid-resistant sudden sensorineural hearing loss: a prospective clinical trial. BMC Medicine 2010;8:76 Google Scholar
6 Carlson, ML, Driscoll, CL, Gifford, RH, Service, GJ, Tombers, NM, Hughes-Borst, BJ et al. Implications of minimizing trauma during conventional cochlear implantation. Otol Neurotol 2011;32:962–8Google Scholar
7 Smith, LP, Eshraghi, AA, Whitley, DE, van de Water, TR, Balkany, TJ. Induction of localized cochlear hypothermia. Acta Otolaryngol 2007;127:228–33Google Scholar
8 Farahmand, Ghavi F, Mirzadeh, H, Imani, M, Jolly, C, Farhadi, M. Corticosteroid-releasing cochlear implant: a novel hybrid of biomaterial and drug delivery system. J Biomed Mater Res B Appl Biomater 2010;94:388–98Google Scholar
9 Niedermeier, K, Braun, S, Fauser, C, Kiefer, J, Straubinger, RK, Stark, T. A safety evaluation of dexamethasone-releasing cochlear implants: comparative study on the risk of otogenic meningitis after implantation. Acta Otolaryngol 2012;132:1252–60CrossRefGoogle ScholarPubMed
10 Quesnel, S, Nguyen, Y, Campo, P, Hermine, O, Ribeil, JA, Elmaleh, M et al. Protective effect of systemic administration of erythropoietin on auditory brain stem response and compound action potential thresholds in an animal model of cochlear implantation. Ann Otol Rhinol Laryngol 2011;120:737–47Google Scholar
11 Lee, KY, Nakagawa, T, Okano, T, Hori, R, Ono, K, Tabata, Y et al. Novel therapy for hearing loss: delivery of insulin-like growth factor 1 to the cochlea using gelatin hydrogel. Otol Neurotol 2007;28:976–81Google Scholar
12 Butt, AJ, Firth, SM, Baxter, RC. The IGF axis and programmed cell death. Immunol Cell Biol 1999;77:256–62CrossRefGoogle ScholarPubMed
13 Camarero, G, Avendano, C, Fernandez-Moreno, C, Villar, A, Contreras, J, de Pablo, F et al. Delayed inner ear maturation and neuronal loss in postnatal Igf-1-deficient mice. J Neurosci 2001;21:7630–41Google Scholar
14 Frago, LM, Cañón, S, de la Rosa, EJ, León, Y, Varela-Nieto, I. Programmed cell death in the developing inner ear is balanced by nerve growth factor and insulin-like growth factor I. J Cell Sci 2003;116:475–86CrossRefGoogle ScholarPubMed
15 Kikkawa, YS, Nakagawa, T, Ying, L, Tabata, Y, Tsubouchi H, Ido A et al. Growth factor-eluting cochlear implant electrode: impact on residual auditory function, insertional trauma, and fibrosis. J Transl Med 2014;12:280 Google Scholar