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Effectiveness of local anaesthesia (clonidine and fentanyl) infiltration for post-submucosal resection pain relief: a randomized, double-blinded clinical trial

Published online by Cambridge University Press:  23 October 2006

M Z Naja ,
M El-Rajab ,
W Kabalan ,
M T Itani ,
K Kharma ,
M A Al Tannir  and
M F Ziade
M Z Naja
Affiliation:
Department of Anesthesia, Makassed General Hospital, Beirut, Lebanon
M El-Rajab
Affiliation:
Department of Pediatrics, Makassed General Hospital, Beirut, Lebanon
W Kabalan
Affiliation:
Department of Ear-Nose-Throat, Makassed General Hospital, Beirut, Lebanon
M T Itani
Affiliation:
Department of Ear-Nose-Throat, Makassed General Hospital, Beirut, Lebanon
K Kharma
Affiliation:
Department of Ear-Nose-Throat, Makassed General Hospital, Beirut, Lebanon
M A Al Tannir
Affiliation:
Research Unit, Makassed General Hospital, Beirut, Lebanon
M F Ziade
Affiliation:
Faculty of Public Health, Lebanese University, Beirut, Lebanon.
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Abstract

Background: Submucosal resection is accompanied by significant post-operative pain and discomfort. The aim of this randomized, double-blinded clinical trial was to study the efficacy of a local block anaesthetic, delivered after induction of general anaesthesia, in reducing post-operative pain.

Methods: Patients aged 16 years and over who were scheduled for elective submucosal resection were randomly assigned to receive either standardized general anaesthesia, general anaesthesia with local anaesthetic infiltration or general anaesthesia with placebo infiltration. Haemodynamic stability, intra-operative blood loss, post-operative pain (over a seven day follow-up period), analgesics consumption, hospital stay, and the patient's and surgeon's levels of satisfaction were assessed.

Results: We found significantly lower results for pack removal pain score, volume of intra-operative blood loss, number of patients suffering from headache, altered dental sensation or nasal pain, number of patients who consumed analgesics, and length of hospital stay, comparing the infiltration group with the general anaesthesia and placebo groups (p<0.05).

Conclusion: This clinical trial showed that infiltration with the local anaesthetics fentanyl and clonidine substantially reduced post-operative pain and shortened patients' hospital stay.

Keywords

Nasal SeptumPerioperative PainOtorhinolaryngologic Surgical ProceduresAnaesthesia, Local
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 121 , Issue 1 , January 2007 , pp. 19 - 24
Copyright
2007 JLO (1984) Limited

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