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Endotoxic damage to the stria vascularis: the pathogenesis of sensorineural hearing loss secondary to otitis media?

Published online by Cambridge University Press:  29 June 2007

Yangchun Guo ,
Yiqin Wu ,
Wenlie Chen  and
Jizhen Lin
Yangchun Guo*
Affiliation:
Department of Otolaryngology, Union Hospital, Fuzhou, China.
Yiqin Wu
Affiliation:
Union Hospital and the Department of Electron Microscopy, Fujian Medical College, Fuzhou, China.
Wenlie Chen
Affiliation:
Union Hospital and the Department of Electron Microscopy, Fujian Medical College, Fuzhou, China.
Jizhen Lin
Affiliation:
Department of Otolaryngology, Union Hospital, Fuzhou, China.
*
Dr Yangchun Guo, Department of Otolaryngology, Union Hospital, Xinquan Road, Fuzhou 350001. PR China.
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Abstract

This study presents animal experiments on endotoxin (lipopolysaccharides: LPS) damage to the inner ear with special reference to the stria vascularis. The experimental group animals (albino guinea pigs) were injected with LPS into the perilymphatic space. Pyrogen-free saline (PFS) was injected into the control group. Strial structural evaluation and hearing tests were carried out before and one, three and five days after treatment. In PFS-treated (control) ears, no significant change was found either in hearing or structure. However, thresholds of Nl/Pl were elevated and latencies prolonged in LPS-treated ears. They had severe strial damage mainly to the cellular organelles. The mitochondria became swollen with a disordered, broken, degenerated or absent crest. Secondary lysosomes and autophagosomes increased in number with the presence of medulative inclusions. Na+-K+-ATPase reactant was obviously diminished. It is concluded that LPS-induced strial ototoxicityproduces ion imbalance, causing changesin endolymph composition and energy failure in the organ of Corti and is also responsible for the pathogenesis of inner ear sequelae secondary to otitis media.

Keywords

EndotoxinsLabyrinthtoxicityOtitis mediaHearing losssensorineural
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 108 , Issue 4 , April 1994 , pp. 310 - 313
Copyright
Copyright © JLO (1984) Limited 1994

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