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Gamma-aminobutyric acid concentrations in benign parotid tumours and unstimulated parotid saliva

Published online by Cambridge University Press:  17 December 2010

E Jezewska ,
A Scinska ,
W Kukwa ,
A Sobolewska ,
D Turzynska ,
J Samochowiec  and
P Bienkowski
E Jezewska
Affiliation:
Department of Otolaryngology, Czerniakowski Hospital, Warsaw Medical University, Warsaw, Poland Consultant Otolaryngologist Unit, Institute of Psychiatry and Neurology, Warsaw, Poland
A Scinska
Affiliation:
Department of Otolaryngology, Czerniakowski Hospital, Warsaw Medical University, Warsaw, Poland Consultant Otolaryngologist Unit, Institute of Psychiatry and Neurology, Warsaw, Poland
W Kukwa
Affiliation:
Department of Otolaryngology, Czerniakowski Hospital, Warsaw Medical University, Warsaw, Poland
A Sobolewska
Affiliation:
Department of Neurochemistry, Institute of Psychiatry and Neurology, Warsaw, Poland
D Turzynska
Affiliation:
Department of Neurochemistry, Institute of Psychiatry and Neurology, Warsaw, Poland
J Samochowiec
Affiliation:
Department of Psychiatry, Pomeranian Medical Academy, Szczecin, Poland
P Bienkowski*
Affiliation:
Department of Pharmacology, Institute of Psychiatry and Neurology, Warsaw, Poland
*
Address for correspondence: Dr Przemyslaw Bienkowski, Department of Pharmacology, Institute of Psychiatry and Neurology, 9 Sobieskiego St, 02-957 Warsaw, Poland Fax: +48 22 84 27 644 E-mail: bienkow@ipin.edu.pl
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Abstract

Objective:

Apart from its role as an inhibitory neurotransmitter, γ-aminobutyric acid is also thought to regulate various stages of cell proliferation and differentiation in the brain and periphery. The present study aimed to assess the levels of γ-aminobutyric acid and its biochemical precursor glutamic acid (glutamate) in benign parotid tumours and in unstimulated parotid saliva.

Method:

Unstimulated parotid saliva was collected bilaterally, using the swab method, in 20 patients with unilateral pleomorphic adenoma or Warthin's tumour. Samples of tumour and adjacent salivary tissue were collected during tumour resection.

Results:

Concentrations of γ-aminobutyric acid and glutamate, but not aspartate, were significantly higher in the tumour tissue than in the non-tumour tissue. There was no significant difference in salivary concentrations of γ-aminobutyric acid, glutamate or aspartate, comparing the involved and non-involved side.

Conclusion:

The present results provide preliminary evidence that γ-aminobutyric acid may be involved in the growth of benign parotid tumours.

Keywords

Parotid NeoplasmsSalivaGamma-Aminobutyric acid
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 125 , Issue 5 , May 2011 , pp. 492 - 496
Copyright
Copyright © JLO (1984) Limited 2010

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