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Laryngeal involvement in pemphigus vulgaris: a proposed classification

Published online by Cambridge University Press:  18 July 2012

A Mahmoud ,
I D Miziara ,
K C Costa ,
C G Santi ,
C W Maruta  and
V Aoki
A Mahmoud*
Affiliation:
Department of ENT, São Paulo University School of Medicine, Brazil
I D Miziara
Affiliation:
Department of ENT, São Paulo University School of Medicine, Brazil
K C Costa
Affiliation:
Department of ENT, São Paulo University School of Medicine, Brazil
C G Santi
Affiliation:
Department of Dermatology, São Paulo University School of Medicine, Brazil
C W Maruta
Affiliation:
Department of Dermatology, São Paulo University School of Medicine, Brazil
V Aoki
Affiliation:
Department of Dermatology, São Paulo University School of Medicine, Brazil
*
Address for correspondence: Dr Ali Mahmoud, Avenida Enéas de Carvalho Aguiar 155, 6° Andar, Sala 06, Cerqueira César, São Paulo, SP, CEP 05403–900, Brazil E-mail: alimahmoud79@gmail.com
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Abstract

Objective:

(1) To investigate the incidence of laryngeal involvement in a large series of patients with pemphigus vulgaris, using endoscopic examination, (2) to describe the lesions, and (3) to establish a classification of laryngeal involvement in pemphigus vulgaris based on the location of the lesions.

Study design:

Prospective study.

Methods:

A total of 40 sequentially treated pemphigus vulgaris patients, diagnosed using clinical, histological and immunofluorescence criteria, were evaluated for laryngeal manifestations using endoscopic examination. The results were used to establish a graded classification of laryngeal involvement according to the location of the lesions.

Results:

Active laryngeal lesions (ulcers or blisters) were found in 16 patients (40 per cent). Of these, 37.5 per cent were classified as grade I, 20 per cent as grade II, 20 per cent as grade III and 17.5 per cent as grade IV.

Conclusion:

Laryngeal involvement is common in pemphigus vulgaris and must be considered at the point of diagnosis. Grade I lesions are the most frequent.

Keywords

PemphigusLarynx
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 126 , Issue 10 , October 2012 , pp. 1041 - 1044
Copyright
Copyright © JLO (1984) Limited 2012

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