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The molecular genetics of head and neck cancer

Published online by Cambridge University Press:  29 June 2007

H. Rowley
H. Rowley*
Affiliation:
Department of Otolaryngology, Royal Victoria Eye and Ear Hospital, Dublin.
*
Address for correspondence: H. Rowley, Department of Otolaryngology, Royal Victoria Eye and Ear Hospital, Adelaide Road, Dublin, Ireland.
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Abstract

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Type
Molecular Biology in Otolaryngology–Head and Neck Surgery Series
Information
The Journal of Laryngology & Otology , Volume 112 , Issue 7 , July 1998 , pp. 607 - 612
Copyright
Copyright © JLO (1984) Limited 1998

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References

Adamson, R., Jones, A. S., Field, J. K. (1994) Loss of heterozygosity on chromosome 17 in head and neck cancer using microsatellite markers. Oncogene 9: 2077–2082.Google ScholarPubMed
Ah-See, K. W., Cooke, T. G., Pickford, J. R., Soutar, D., Balmain, A. (1994) An allelotype of squamous carcinoma of the head and neck using microsatellite markers. Cancer Research 54: 1617–1621.Google ScholarPubMed
Bowen, I. D., Bowen, S. M. (1990) Techniques for demonstrating cell death. In Programmed Cell Death in Tumours and Tissues, (Bowen, I. D., Ed.) Chapman and Hall, London, pp 179–213.Google Scholar
Boyle, J. O., Koch, W. M., Hruban, R. H., van der Riet, P., Sidransky, , (1993) The incidence of p53 mutations increases with progression of head and neck cancer. Cancer Research 53: 4477–4480.Google ScholarPubMed
Boyle, J. O., Mao, L., Brennan, J. A., Koch, W. M., Eisele, D. W., Saunders, J. R., Sidransky, D. (1994) Gene mutations in saliva as molecular markers for head and neck squamous cell carcinomas. American Journal of Surgery 168: 429–432.CrossRefGoogle ScholarPubMed
Brennan, J. A., Boyle, J. A., Koch, W. M., Goodman, S. N., Hruban, R. H., Eby, Y. J., Couch, M. J., Forastiere, A. A., Sidransky, D. (1995a) Association between cigarette smoking and mutation of the p53 gene in squamous cell carcinoma of the head and neck. New England Journal of Medicine 332: 712–717.CrossRefGoogle ScholarPubMed
Brennan, J. A., Mao, I., Hruban, R. H., Boyle, J. A., Eby, Y. J., Koch, W. M., Goodman, S. N., Sidransky, D. (1995b) Molecular assessment of histopathological staging in squamous cell carcinoma of the head and neck. New England Journal of Medicine 332: 429–435.CrossRefGoogle ScholarPubMed
Califano, J., Ahrendt, S. A., Meininger, G., Westra, W., Koch, W., Sidransky, D. (1996) Detection of telomerase activity in oral rinses from head and neck squamous cell carcinoma patients. Cancer Research 56: 5720–5722.Google ScholarPubMed
Callender, T., El-Nagger, A. K., Lee, M. S., Frankenthaler, R., Luna, M. A., Batsakis, J. G. (1994) PRAD-1 (CCND1)/ cyclin Dl oncogene amplification in primary head and neck squamous cell carcinoma. Cancer 74: 152–158.3.0.CO;2-K>CrossRefGoogle Scholar
Carbone, D. (1992) Smoking and cancer. American Journal of Medicine 92 (Suppl 1A): 13S–17S.CrossRefGoogle Scholar
Carey, T. E., Van Dyke, D. L., Worsham, M. J. (1993) Nonrandom chromosomes aberrations and clonal populations in head and neck cancer. Anticancer Research 13: 2561–2568.Google ScholarPubMed
Clayman, G. L., El-Nagger, A. K., Roth, J. A., Zhang, W. W.. Goepfert, H., Taylor, D. L., Liu, T-J. (1995) In vivo molecular therapy with p53 adenovirus for microscopic residual head and neck squamous carcinoma. Cancer Research 55: 1–6.Google ScholarPubMed
El-Nagger, A. K., Hurr, K., Batsakis, J. G., Luna, M. A., Goepfert, H., Huff, V. (1995) Sequential loss of hetero-zygosity at microsatellite motifs in preinvasive and invasive head and neck squamous carcinoma. Cancer Research 55: 2656–2659.Google Scholar
Fearon, E. R., Vogelstein, B. (1991) A genetic model of colorectal tumorigenesis. Cell 61: 759–767.CrossRefGoogle Scholar
Hermeking, H., Eick, D. (1994) Mediation of c-myc-induced apoptosis by p53. Science 265: 2091–2093.CrossRefGoogle ScholarPubMed
Jares, P., Fernandez, P. L., Campo, E., Nadal, A., Bosch, F., Aiza, G., Nayach, I., Traserra, J., Cardesa, A. (1994) PRAD-1/cyclin Dl gene amplification correlates with messenger RNA overexpression and tumor progression in human laryngeal carcinomas. Cancer Research 54: 4813–4817.Google Scholar
Kamb, A., Gruis, N. A., Weaverfeldhaus, J., Liu, Q. Y., Harshman, K. (1994) A cell cycle regulator potentially involved in genesis of many tumour types. Science 264: 436–440.CrossRefGoogle Scholar
Liggett, W. H., Sewell, D. A., Rocco, J., Ahrendt, S. A., Koch, W. M., Didransky, D. (1996) p16 and p16B are potent growth suppressors of head and neck squamous carcinoma cells in vivo. Cancer Research 56: 4119–4123.Google Scholar
Liloglou, T., Scholes, A. G., Spandidos, D. A., Vaughan, E. D., Jones, A. S., Field, J. K. (1997) p53 mutations in squamous cell carcinoma of the head and neck predominate i n a subgroup of former and present smokers with a low frequency of genetic instability. Cancer Research 57: 4070–4074.Google Scholar
Loughran, O., Clark, I. J., Bond, J., Baker, A., Berry, L. J., Edington, K. G., Ly, I. S., Simmons, R., Haw, R., Black, B. M., Newbold, R. F., Parkinson, E. K. (1997) Evidence for the inactivation of multiple replicative lifespan genes in immortal human squamous cell carcinoma keratinocytes. Oncogene 14: 1955–1964.CrossRefGoogle ScholarPubMed
Lowe, S. W., Schmitt, E. M., Smith, S. W., Osborne, B. A., Jacke, T. (1993) p53 is required for radiation induced apoptosis in mouse thymocytes. Nature 362: 847–849.CrossRefGoogle ScholarPubMed
Maestro, R., Gasparotto, D., Vuksavljevic, T., Barzan, L., Sulfaro, S., Boicchi, M. (1993) Three discrete areas of deletion in head and neck cancers. Cancer Research 53: 5775–5779.Google ScholarPubMed
Mao, L., El-Naggar, A. K., Fan, Y.-H., Lee, J. S., Lippman, S. M., Kayser, S., Lotan, R., Hong, W. K. (1996) Telomerase activity in head and neck squamous cell carcinoma and adjacent tissues. Cancer Research 56: 5600–5604.Google ScholarPubMed
Mao, L., Hruban, R. H., Boyle, J., Tockman, M., Sidransky, D. (1994) Detection of oncogene mutations in sputum precedes diagnosis of lung cancer. Cancer Research 54: 1634–1637.Google ScholarPubMed
Michalides, R., van Neeklan, N., Hart, A., Loftus, B., Wientjens, E., Balm, A. (1995) Overexpression of cyclin Dl correlates with recurrence in a group of 47 operable squamous cell carcinomas of the head and neck. Cancer Research 55: 975–978.Google Scholar
Mutirangura, A., Tanunuyutthawongese, C, Pornthanakasem, W., Kerekhanjanarong, V., Sriuranpong, V., Yenrudi, S., Supiyaphun, P., Voravud, N. (1997) Genomic alterations in nasopharyngeal carcinoma: loss of heterozygosity and Epstein-Barr virus infection. British Journal of Cancer 76: 770–776.CrossRefGoogle ScholarPubMed
Nawroz, H., van der Riet, P., Hruban, R. H., Koch, W. M., Ruppert, J. M., Sidransky, D. (1994) Allelotype of head and neck squamous cell carcinoma. Cancer Research 54: 1152–1155.Google ScholarPubMed
Nees, M., Homann, N., Discher, H., Andl, T., Enders, C, Herold-Mende, C, Schuhmann, A., Bosch, F. X. (1993) Expression of mutated p53 occurs in tumour distant epithelia of head and neck cancer patients: a possible molecular basis for the development of multiple tumors. Cancer Research 53: 4189–4196.Google ScholarPubMed
Parkin, D. M., Laara, F., Muir, C. S. (1988) Estimates of the world-wide frequency of 16 major cancers in 1980. International Journal of Cancer 41: 19–36.CrossRefGoogle Scholar
Pavelic, Z. P., Gluckman, J. L. (1997) The role of p53 tumor suppressor gene in human head and neck tumorigenesis. Acta Otolaryngologica (Suppl) 527: 21–24.CrossRefGoogle ScholarPubMed
Puisieux, A., Lim, S., Groopman, J., Ozturk, M. (1991) Selective targetting of p53 gene mutational hotspots in human cancers by etiologically defined carcinogens. Cancer Research 51: 6185–6189.Google ScholarPubMed
Reithdorf, S., Friedrich, R. E., Ostwald, C, Barten, M., Gogacz, P., Gundlach, K. K., Schechte, I. I., Becker, J., Bregenzer, T., Reichdorf, L., Loning, T. (1997) p53 gene mutations and HPV infection in primary head and neck squamous cell carcinomas do not correlate with overall survival: a longterm follow-up study. Journal of Oral Pathology and Medicine 26: 315–321.CrossRefGoogle Scholar
Renan, M. J. (1993) How many mutations are required for tumorigenesis? Implications from human cancer data. Molecular Carcinogenesis 7: 139–146.Google ScholarPubMed
Rowley, H. (1997) MD Thesis. Cell biological markers of prognosis in squamous cell carcinoma of the head and neck. National University of Ireland, Galway, Ireland.Google Scholar
Rowley, H., Helliwell, T. R., Jones, A. S., Roland, N. R., Field, E. A., Field, J. K. (1997) An immunohistochemical analysis of p53 protein expression in pre-malignant and malignant tissues of the oral cavity. Clinical Otolaryngology 22: 23–29.CrossRefGoogle ScholarPubMed
Rowley, H., Jones, A. S., Field, J. K. (1995) Chromosome 18: a possible site for a tumor suppressor gene deletion in squamous cell carcinoma of the head and neck. Clinical Otolaryngology 20: 266–271.CrossRefGoogle ScholarPubMed
Rowley, H., Jones, A. S., Spandidos, D., Field, J. K. (1996) Definition of a tumor suppressor gene locus on chromosome 3 in squamous cell carcinoma of the head and neck by means of microsatellite markers. Archives of Otolaryngol-ogy-Head and Neck Surgery 122: 497–501.CrossRefGoogle ScholarPubMed
Rowley, H., Sherrington, P., Kinsella, A. R., Helliwell, T. R., Jones, A. S. (1998) p53 protein expression and p53 mutations in pre-malignant and malignant tissues of the oral cavity. Otolaryngology-Head and Neck Surgery 118: 115–121.CrossRefGoogle Scholar
Roz, L., Wu, C. L., Porter, S., Scully, C., Speight, P., Read, A., Sloan, P., Thakker, N. (1996) Allelic imbalance on chromosome 3p in oral dysplastic lesions: an early event i n oral carcinogenesis. Cancer Research 56: 1228–1231.Google Scholar
Serrano, M., Hannon, G. J. (1993) A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/ CDK4. Nature 366: 704–707.CrossRefGoogle ScholarPubMed
Sheng, Z. M., Barrois, M., Klijanienko, J., Micheau, C, Richard, J. M., Riou, G. (1990) Analysis of c-Ha-ras-1 gene for deletion, mutation, amplification and expression in lymph node metastases of human head and neck carcinomas. British Journal of Cancer 62: 398–404.CrossRefGoogle ScholarPubMed
Sidransky, D., Preisinger, A. G., Frost, P., Oyasu, T., Vogelstein, B. (1992) Clonal origin of metachronous tumors of the bladder. New England Journal of Medicine 326: 737–740.CrossRefGoogle Scholar
Speicher, M. R., Howe, C., Crotty, P., Du Manoir, S., Costa, J., Ward, D. C. (1995) Comparative genomic hybridization detects novel deletions and amplifications in head and neck squamous cell carcinomas. Cancer Research 55:1010–1013.Google ScholarPubMed
Spitz, M. R., McPherson, R. S., Jiang, H., Hsu, T. C., Trizna, Z., Lee, J. J., Lippman, S. M., Khuri, F. R., Steffen-Batey, L., Chamberlain, R. M., Schantz, P. P., Hong, W. K. (1997) Correlates of mutagen sensitivity in patients with upper aerodigestive tract cancer. Cancer Epidemiology Biomar-kers and Prevention 6: 687–692.Google ScholarPubMed
van der Riet, P., Nawroz, H., Hruban, R. H., Corio, R., Tokino, K., Koch, W. M., Sidransky, D. (1994) Frequent loss of chromosome 9p21–22 early in head and neck cancer progression. Cancer Research 54: 1156–1158.Google ScholarPubMed
Van Dyke, D. I., Worsham, M. J., Benninger, M. S., Krause, C. J., Baker, S. R., Wolf, G. T., Drumheller, T., Tilley, B. C., Carey, T. E. (1994) Recurrent cytogenetic abnormalities in squamous cell carcinoma of the head and neck region. Genes Chromosomes and Cancer 9: 192–206.CrossRefGoogle ScholarPubMed
Vogelstein, B., Kinzler, K. W. (1992) Carcinogens leave fingerprints. Nature 355: 209–210.CrossRefGoogle ScholarPubMed
Vokes, E. E., Weichselbaum, R. R., Lippman, S. M., Hong, W. K. (1993) Head and Neck Cancer. New England Journal of Medicine 328(3): 184–192.CrossRefGoogle ScholarPubMed
Waridel, F., Estreicher, A., Bron, L., Flaman, J. M., Fontolliet, C., Monnier, P., Frebourg, T., Iggo, R. (1997) Field cancerization and polyclonal p53 mutation in the upper aerodigestive tract. Oncogene 14: 163–169.CrossRefGoogle Scholar
Werness, B. A., Levine, A. J., Howley, P. M. (1990) The E6 proteins encoded by human papillomavirus types 16 and 18 can complex p53 in vitro. Science 248: 76–79.CrossRefGoogle Scholar
Williams, M. E., Gaffey, M. J., Weiss, L. M., Wilczynski, S. P., Schuurring, E., Levine, P. A. (1993) Chromosome Ilq13 amplification in head and neck squamous cell carcinoma. Archives of Otolaryngology-Head and Neck Surgery 119: 1238–1243.CrossRefGoogle ScholarPubMed
Worsham, M. J., Wolman, S. R., Carey, T. E., Zarbo, R. J., Benninger, M. S., Van Dyke, D. I. (1995) Common clonal origin of synchronous primary head and neck squamous cell carcinomas. Human Pathology 26: 251–261.CrossRefGoogle ScholarPubMed
Xu, L., Davidson, B. J., Murty, V. V. S. (1994) Tp53 gene mutations and CCND1 gene amplification in squamous cell carcinoma cell lines. International Journal of Cancer 59: 383–387.CrossRefGoogle ScholarPubMed
Yoo, G. H., Xu, H-J., Brennan, J. A., Westra, W., Hruban, R. H., Koch, W. M., Benedict, W. F., Sidransky, D. (1994) Infrequent inactivation of the retinoblastoma gene despite frequent loss of chromosome 13q in head and neck squamous cell carcinoma. Cancer Research 54: 4603–1606.Google ScholarPubMed