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Protective effects of vitamins E, B and C and l-carnitine in the prevention of cisplatin-induced ototoxicity in rats

Published online by Cambridge University Press:  11 April 2012

S Alıcura Tokgöz ,
E Vuralkan ,
N D Sonbay ,
M Çalişkan ,
C Saka ,
Ö Beşalti  and
İ Akin
S Alıcura Tokgöz*
Affiliation:
First ENT Clinic, Ministry of Health Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey
E Vuralkan
Affiliation:
First ENT Clinic, Ministry of Health Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey
N D Sonbay
Affiliation:
First ENT Clinic, Ministry of Health Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey
M Çalişkan
Affiliation:
Faculty of Veterinary Medicine, Ankara University, Turkey
C Saka
Affiliation:
First ENT Clinic, Ministry of Health Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey
Ö Beşalti
Affiliation:
Faculty of Veterinary Medicine, Ankara University, Turkey
İ Akin
Affiliation:
First ENT Clinic, Ministry of Health Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey
*
Address for correspondence: Dr Sibel Alicura Tokgöz, First ENT Clinic, Dışkapı Yldırım Beyazıt Training and Research Hospital, Ministry of Health, Ankara, Turkey E-mail: salicura@yahoo.com
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Abstract

Objective:

This experimental study aimed to investigate the effects of vitamins E, B and C and l-carnitine in preventing cisplatin-induced ototoxicity.

Methods:

Twenty-five adult, male, Wistar albino rats were randomly allocated to receive intraperitoneal cisplatin either alone or preceded by vitamins B, E or C or l-carnitine. Auditory brainstem response (i.e. hearing thresholds and wave I–IV intervals) and distortion product otoacoustic emissions (i.e. signal-to-noise ratios) were recorded before and 72 hours after cisplatin administration.

Results:

The following statistically significant differences were seen: control group pre- vs post-treatment wave I–IV interval values (p < 0.05); control vs vitamin E and B groups' I–IV interval values (p < 0.05); control vs other groups' hearing thresholds; vitamin E vs vitamin B and C and l-carnitine groups' hearing thresholds (p < 0.05); and vitamin B vs vitamin C and l-carnitine groups' hearing thresholds (p < 0.05). Statistically significant decreases were seen when comparing the initial and final signal-to-noise ratios in the control, vitamin B and l-carnitine groups (2000 and 3000 Hz; p < 0.01), and the initial and final signal-to-noise ratios in the control group (at 4000 Hz; p < 0.01).

Conclusion:

Vitamins B, E and C and l-carnitine appear to reduce cisplatin-induced ototoxicity in rats. The use of such additional treatments to decrease cisplatin-induced ototoxicity in humans is still under discussion.

Keywords

OtotoxicityCisplatinEar, InnerAntioxidantsRat
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 126 , Issue 5 , May 2012 , pp. 464 - 469
Copyright
Copyright © JLO (1984) Limited 2012

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