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Serum antibodies to human herpesvirus 7, human herpesvirus 6 and cytomegalovirus in patients with idiopathic facial nerve palsy or sudden deafness

Published online by Cambridge University Press:  29 June 2007

Tomohiko Takasaki ,
Masahiko Higashikawa ,
Soichi Motoyama ,
Kunihiro Sugita  and
Ichiro Kurane
Tomohiko Takasaki*
Affiliation:
Department of Microbiology, Kinki University School of Medicine, Osaka, 589, Japan.
Masahiko Higashikawa
Affiliation:
Department of Otolaryngology, Osaka Medical College, Osaka, 569, Japan.
Soichi Motoyama
Affiliation:
Department of Otolaryngology, Saiseikai Nakatsu Hospital, Osaka, 530, Japan.
Kunihiro Sugita
Affiliation:
Department of Microbiology, Kinki University School of Medicine, Osaka, 589, Japan. Department of Otolaryngology, Saiseikai Nakatsu Hospital, Osaka, 530, Japan.
Ichiro Kurane
Affiliation:
Department of Microbiology, Kinki University School of Medicine, Osaka, 589, Japan.
*
Address for correspondence: Tomohiko Takasaki, M.D., Department of Microbiology, Kinki University School of Medicine, 377-2 Ohno-higashi, Osakasayama, Osaka 589Japan, Fax: 81-723-67-3606
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Abstract

The aetiology of idiopathic facial nerve palsy (Bell's palsy) and sudden deafness are not known, although viruses have been suspected as a cause of them. We investigated the relationship between Bell's palsy or sudden deafness, and reactivation of cytomegalovirus, human herpesvirus 6 (HHV-6) and 7 (HHV-7).

Paired sera were collected from 22 patients with Bell's palsy and 24 patients with sudden deafness. IgG antibody titres to HHV-7 were increased in one patient with Bell's palsy. IgG antibody titres to HHV-6 were increased in one patient with Bell's palsy and two with sudden deafness. IgG antibody titres to cytomegalovirus were increased in one patient with sudden deafness. Titres of the three viral antibodies were not increased simultaneously in any patients. These viruses may contribute to the development of Bell's palsy or sudden deafness in some cases. It is, however, unlikely that these viruses are the main cause of Bell's palsy and sudden deafness in the majority of patients.

Keywords

Facial paralysisHearing losssensorineuralCytomegalovirusesHerpesvirus-6, humanHerpesvirus-7, human
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 112 , Issue 7 , July 1998 , pp. 617 - 621
Copyright
Copyright © JLO (1984) Limited 1998

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References

Adour, K. K., Bell, D. N., Hilsinger, R. L. Jr. (1975) Herpes simplex virus in idiopathic facial paralysis (Bell's palsy). Journal of the American Medical Association 233: 527–530.CrossRefGoogle Scholar
Beardwell, A. (1969) Facial palsy due to mumps virus. British Journal of Clinical Practice 23: 37–38.Google ScholarPubMed
Berneman, Z. N., Ablashi, D. V., Li, G., Eger-Fletcher, M, Reiz, M. S. Jr., Hung, C.-L., Komaroff, A. L., Gallo, R. C. (1992) Human herpesvirus 7 is a T-lymphotropic virus is related to, but significantly different from, human herpes-virus 6 and human cytomegalovirus. Proceedings of the National Academy of Sciences of the USA 89: 10552–10556.CrossRefGoogle ScholarPubMed
Davis, G. L., James, C. G., Fiber, F., McLaren, L. C. (1979) Cytomegalovirus isolation from a human inner ear. Annals of Otology, Rhinology and Laryngology 88: 424–426.CrossRefGoogle ScholarPubMed
Diupesland, G., Berdal, P., Johannessen, T. A., Degre, M., Stein, R., Skrede, S. (1976) Viral infection as a cause of acute periferal facial palsy. Archives of Otolaryngology 102: 403–406.CrossRefGoogle Scholar
Grose, C., Feorino, P. M., Dye, L. A., Rand, J. (1972) Bell's palsy and infectious mononucleosis. Lancet ii: 231–232.Google Scholar
Frenkel, N., Schirmer, E. C., Wyatt, L. S., Katsufanas, G., Roffman, G., Roffman, E., Donovich, R. M., June, C. H. (1990) Isolation of a new herpesvirus from human CD4+ T cells. Proceedings of the National Academy of Sciences of the USA 87: 748–752.CrossRefGoogle ScholarPubMed
Hadar, T., Tovi, F., Sidi, J., Sarov, B., Sarov, I. (1983) Specific IgG and IgA antibodies to herpes simplex virus and varicella-zoster virus in acute peripheral facial palsy. Journal of Medical Virology 12: 237–245.CrossRefGoogle ScholarPubMed
Hallberg, O. E. (1956) Sudden deafness of obscure origin. Laryngoscope 66: 1237–1267.CrossRefGoogle ScholarPubMed
Korczyn, A. D., Swirski, R., Henig, E. (1973) Bell's palsy and viral infections. European Neurology 10: 191–196.CrossRefGoogle ScholarPubMed
Luca, D. D., Zorzenon, M., Mirandola, P., Colle, R., Botta, G. A., Cassai, E. (1995) Human herpesvirus 6 and human herpesvirus 7 in chronic fatigue syndrome. Journal of Clinical Microbiology 33: 1660–1661.CrossRefGoogle ScholarPubMed
Mattox, D. E., Lyles, C. A. (1989) Idiopathic sudden sensorineural hearing loss. American Journal of Otology 10: 242–247.Google ScholarPubMed
Okuno, T., Higashi, K., Shiraki, K., Yamanishi, K., Takahashi, M, Kokado, Y., Ishibashi, M., Takahara, S., Sonoda, T., Tanaka, K., Baba, K., Yabuuchi, H., Kurata, T. (1990) Human herpesvirus 6 infection in renal transplantation. Transplantation 49: 519–522.CrossRefGoogle ScholarPubMed
Okuno, T., Takahashi, K., Balachandra, K., Shiraki, K., Yamanishi, K., Takahashi, M, Baba, K. (1989) Seroepide-miology of human herpesvirus 6 infection in normal children and adults. Journal of Clinical Microbiology 27: 651–653.CrossRefGoogle ScholarPubMed
Salahuddin, S. Z., Ablashi, D. V., Markham, P. D., Josephs, S. F., Stuzenegger, S., Kaplan, M, Halligan, G., Biberfeld, P., Staal, F. W., Kramarsky, B., Gallo, R. C. (1986) Isolation of a new virus, HBLV, in patients with lymphoproliferative disorders. Science 234: 596–601.CrossRefGoogle ScholarPubMed
Schuknecht, H. F., Donovan, E. D. (1986) The pathology of idiopathic sudden hearing loss. Archives of Oto-Rhino-Laryngology 243: 1–15.CrossRefGoogle Scholar
Taavik, T., Støhrvold, G., Sundsfjord, A., Lund, S., Mair, I. W. S. (1983) Peripheral facial palsy and coincidental cytome-galovirus infection or reactivation. Scandinavian Journal of Infectious Diseases 15: 233–238.CrossRefGoogle Scholar
Takasaki, T., Motoyama, S., Ohinata, Y., Sugita, K., Fujiwara, Y., Fujii, N., Higashikawa, M., Makimoto, K., Yamaguchi, J., Takahashi, H. (1994) Peripheral facial nerve palsy preceding the febrile period of exanthema subitum: A case report. Pediatric Otorhinolaryngology Japan 15: 34–36.Google Scholar
Veltri, R. W., Wilson, W. R., Sprinkle, P. M., Rodman, S. M., Kavesh, D. A. (1981) The implication of viruses in idiopathic sudden sensorineural hearing loss: primary infection or reactivation of latent viruses. Otolaryngology-Head and Neck Surgery 89: 137–141.CrossRefGoogle ScholarPubMed
Wells, C. E. C. (1971) Neurological complication of so called ‘influenza’. A winter study in southeast Wales. British Medical Journal 13: 369–373.CrossRefGoogle Scholar
Wyatt, L. S., Rodrigues, W. J., Balachandran, N., Frenkel, N. (1991) Human herpes virus 7: Antigemc properties and prevalence in children and adults. Journal of Virology 65: 6260–6265.CrossRefGoogle Scholar