Hostname: page-component-78c5997874-s2hrs Total loading time: 0 Render date: 2024-11-08T05:34:29.208Z Has data issue: false hasContentIssue false

Squamous cell carcinoma of the larynx with osteoclast-like giant cells

Published online by Cambridge University Press:  29 June 2007

A. Ferlito*
Affiliation:
Department of Otolaryngology, Padua University, Padua, Italy.
I. Fmedmann
Affiliation:
Department of Histopathology, Northwick Park Hospital, Harrow, England.
G. Recher
Affiliation:
Division of Otolaryngology, St. Bortolo Hospital, Vicenza, Italy.
*
Professor Alfio Ferlito, ENT Department of Padua University, via Giustiniani 2, 35100 Padova (Italy).

Abstract

An unusual squamous cell carcinoma of the larynx containing numerous multinucleated osteoclast-like giant cells in described. These cells occurred in areas of vigorous angiogenesis and haemorrhage. To our knowledge, this is the first case of laryngeal squamous cell carcinoma with osteoclast-like giant cells reported in the literature. The patient has remained alive and free of clinical disease 5 years and 4 months after the original diagnosis.

Type
Clinical Records
Copyright
Copyright © JLO (1984) Limited 1987

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Agnantis, N. T. and Rosen, P. P. (1979) Mammary carcinoma with osteoclast-like giant cells. A study of eight cases with follow-up data. American Journal of Clinical Pathology, 72: 383389.Google Scholar
Alguacil-Garcia, A., Alonso, A. and Pettigrew, N. M. (1984) Sarcomatoid carcinoma (so-called pseudosarcoma) of the laryx simulating malignant giant cell tumor of soft parts. American Journal of Clinical Pathology, 82: 340343.CrossRefGoogle Scholar
Alpers, C. E. and Beckstead, J. A. (1985) Malignant neuroendocrine tumor of the jejunum with osteoclast-like giant cells. Enzyme histochemistry distinguishes tumor cells from the giant cells. American Journal of Surgical Pathology, 9: 5764.CrossRefGoogle ScholarPubMed
Andreola, S., Lombardi, L., Scurelli, A. and Bersiga, A. (1985) Osteoclastoma-like giant-cell tumor of the liver. Case report. Tumori, 71: 615620.CrossRefGoogle ScholarPubMed
Balogh, K., Welbarsht, R. L., Federman, M. and O'Hara, C. J. (1985) Carcinoma of the parotid gland with osteoclast-like giant cells. Immunohistochemi-cal and ultrastructural observations. Archives of Pathology and Laboratory Medicine, 109: 756761.Google Scholar
Dahm, L. J., Schaefer, S. D., Carder, H. M. and Vellios, F. (1978) Osteosarcoma of the soft tissue of the larynx. Report of a case with light and electron microscopic studies. Cancer, 42: 23432351.Google Scholar
Darby, A. J., Papadaki, L. and Beilby, J. O. W. (1975) An unusual leiomyosarcoma of the uterus containing osteoclast-like giant cells. Cancer, 36: 495504.3.0.CO;2-I>CrossRefGoogle ScholarPubMed
Dorney, P. (1967) Osteoclastoma of the heart. British Heart Journal, 29: 276278.Google Scholar
Eshun-Wilson, K. (1973) Malignant giant-cell tumor of the colon. Acta Pathologica et Microbiologica Scandinavica (A), 81: 137144.Google Scholar
Factor, S. M., Biempica, L., Ratner, I., Ahuja, K. K. and Biempica, S. (1977) Carcinoma of the breast with multinucleated reactive stroma giants cells. A light and electron microscopic study of two cases. Virchows Archiv; A: Pathological Anatomy and Histology, 374: 112.Google Scholar
Ferlito, A., Nicolai, P., Recher, G. and Name, S. (1983) Primary laryngeal malignant fibrous histiocytoma: review of the literature and report of seven cases. Laryngoscope, 93: 13511358.CrossRefGoogle ScholarPubMed
Goellner, J. R., Devine, K. D. and Weiland, L. H. (1973) Pseudosarcoma of the larynx. American Journal of Clinical Pathology, 59: 312326.CrossRefGoogle ScholarPubMed
Hashimoto, H., Koga, S., Watanabe, H. and Enjoji, M. (1980) Undifferentiated carcinoma of the thyroid gland with osteoclast-like giant cells. Acta Pathologica Japonica, 30: 323334.CrossRefGoogle Scholar
Holland, R. and van Haelst, U. J. G. M. (1984) Mammary carcinoma with osteoclast-like giant cells. Additional observations of six cases. Cancer, 53: 19631973.Google Scholar
Holtz, F., Fox, J. E. and Abelli, M. R. (1972) Car-cinosarcoma of the urinary bladder. Cancer, 29: 294304.Google Scholar
Kenney, R. M., Prat, J. and Tabernero, M. (1984) Giant-cell tumor-like proliferation associated with a papillary transitional cell carcinoma of the renal pelvis. American Journal of Surgical Pathology, 8: 139144.CrossRefGoogle ScholarPubMed
Kuwano, H., Sonoda, T., Hashimoto, H. and Enjoji, M. (1984) Hepatocellular carcinoma with osteoclast-like giant cells. Cancer, 54: 837842.Google Scholar
Mallory, F. B. and Stewart, F. W. (1927) Fibrosar-coma with osteoclast-like giant cells. American Journal of Pathology, 3: 8589.Google Scholar
Munoz, P. A., Rao, M. S. and Reddy, J. K. (1980) Osteoclastoma-like giant cell tumor of the liver. Cancer, 46: 771779.Google Scholar
Nielsen, B. B. and Kiaer, H. W. (1985) Carcinoma of the breast with stomal multinucleated giant cells. Histopathology, 9: 183193.Google Scholar
Oyasu, R., Battifora, H. A., Buckingham, W. B. and Hidvegi, D. (1977) Metaplastic squamous cell carcinoma of bronchus simulating giant cell tumor of bone. Cancer, 39: 11191128.Google Scholar
Pettinato, G., Petrella, G., Manco, A., di Prisco, B., Salvatore, G. and Angrisani, P. (1984) Carcinoma of the breast with osteoclast-like giant cells. Fine-needle aspiration cytology, histology and electron microscopy of 5 cases. Applied Pathology, 2: 168178.Google Scholar
Prat, J. and Scully, R. E. (1979) Ovarian mucinous tumors with sarcoma-like mural nodules. A report of seven cases. Cancer, 44: 13321344.3.0.CO;2-#>CrossRefGoogle ScholarPubMed
Rosai, J. (1968) Carcinoma of pancreas simulating giant cell tumor of bone. Electron microscopic evidence of its acinar origin. Cancer, 22; 333344.Google Scholar
Veliath, A. J., Sankaran, V. and Aurora, A. L. (1975) Ovarian giant cell tumor with cystadenocarcinoma. Archives of Pathology, 99: 488491.Google Scholar