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Surgical treatment of glottic cancer: retrospective analysis of 192 cases in a multidisciplinary tertiary care centre in Pune, India

Published online by Cambridge University Press:  16 February 2015

D S Kelkar ,
S S Gandhi  and
G A Oka
D S Kelkar*
Affiliation:
Division of Surgical Oncology, Deenanath Mangeshkar Hospital and Research Centre, Pune, India
S S Gandhi
Affiliation:
Division of Surgical Oncology, Deenanath Mangeshkar Hospital and Research Centre, Pune, India
G A Oka
Affiliation:
Department of Research, Deenanath Mangeshkar Hospital and Research Centre, Pune, India
*
Address for correspondence: Dr D S Kelkar, Division of Surgical Oncology, Deenanath Mangeshkar Hospital, Erandawane, Pune – 411004, MS, India E-mail: dskelkar@gmail.com
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Abstract

Objectives:

A multidisciplinary team approach is required for the preservation of voice and appropriate management of glottic cancer. This study aimed to investigate the outcomes of surgically treated glottic cancers of all stages. All aspects of surgical management, such as laser cordectomy, partial laryngectomy, total laryngectomy with voice prosthesis, and salvage laryngectomy, conducted at a single tertiary care institute in India, were reviewed.

Method:

A retrospective analysis of hospital records was performed for 192 glottic cancer patients who were surgically treated between 2003 and 2007.

Results:

Patients with tumour stages 1 or 2 glottic cancer treated with laser cordectomy had a local control rate of 85 per cent and five-year survival rate of 98.6 per cent. The findings suggest that the number of partial laryngectomies performed for stage 3 tumours is declining. Patients with a tumour stage 3 lesion with a fixed hemilarynx or a tumour stage 4 lesion, treated with total laryngectomy, were found to have a five-year survival rate of 61.6 per cent. Nodal status was significantly associated with five-year survival rate.

Conclusion:

Surgery offers a viable five-year survival rate in glottic cancer patients.

Keywords

LaryngectomyLaserAdjuvant RadiotherapyVoice Prosthesis
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 129 , Issue 3 , March 2015 , pp. 261 - 266
Copyright
Copyright © JLO (1984) Limited 2015 

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Footnotes

Dr D S Kelkar is The Journal of Laryngology & Otology 2014 Visiting Professor.

References

1Indian States Census 2011. In: http://www.census2011.co.in/states.php [4 January 2015]Google Scholar
2National Cancer Registry Programme (NCRP). Three Year Report of the Population Based Cancer Registries 2006-2008. New Delhi: Indian Council of Medical Research, 2010Google Scholar
3Cancer Treatment Centres Licenced by Atomic Energy Regulatory Board (updated till 31/05/2012). In: http://www.aerb.gov.in/AERBPortal/pages/English/t/forms/regforms/radiotherapy/radiotherapy.pdf [23 January 2015]Google Scholar
4Jayalekshmi, PA, Nandakumar, A, Akiba, S, Gangadharan, P, Koriyama, C. Associations of tobacco use and alcohol drinking with laryngeal and hypopharyngeal cancer risks among men in Karunagappally, Kerala, India – Karunagappally cohort study. PLoS One 2013;8:e73716Google Scholar
5International Union Against Cancer (UICC). In: Sobin, LH, Wittekind, C, eds. TNM Classification of Malignant Tumours, 6th ed.New York: Wiley, 2002Google Scholar
6Remacle, M, Eckel, HE, Antonelli, A, Brasnu, D, Chevalier, D, Friedrich, G et al. Endoscopic cordectomy. A proposal for a classification by the Working Committee, European Laryngological Society. Eur Arch Otorhinolaryngol 2000;257:227–31CrossRefGoogle ScholarPubMed
7Moreau, PR. Treatment of laryngeal carcinoma by laser endoscopic microsurgery. Laryngoscope 2000;110:1000–6CrossRefGoogle ScholarPubMed
8Peretti, G, Nicolai, P, Redaelli De Zinis, LO, Berlucchi, M, Bazzana, T, Bertoni, F et al. Endoscopic CO2 laser excision for tis, T1, and T2 glottic carcinomas: cure rate and prognosis factors. Otolaryngol Head Neck Surg 2000;123:124–31Google Scholar
9Batalla, FN, Cueva, MJC, González, BS, Pendás, JLL, Gil, CG, Llames, AL et al. Voice quality after endoscopic laser surgery and radiotherapy for early glottic cancer: objective measurements emphasizing the Voice Handicap Index. Eur Arch Otorhinolaryngol 2008;265:543–8Google Scholar
10Delsupehe, KG, Zink, I, Lejaegere, M, Bastian, RW. Voice quality after narrow-margin laser cordectomy compared with laryngeal irradiation. Otolaryngol Head Neck Surg 1999;121:528–33Google Scholar
11Steiner, W. Experience in endoscopic laser surgery of malignant tumours of the upper aero-digestive tract. Adv Otorhinolaryngol 1988;39:135–44Google Scholar
12Mortuaire, G, Francois, J, Wiel, E, Chevalier, D. Local recurrence after CO2 laser cordectomy for early glottic carcinoma. Laryngoscope 2006;116:101–5Google Scholar
13Michel, J, Fakhry, N, Duflo, S, Lagier, A, Mancini, J, Dessi, P et al. Prognostic value of the status of resection margins after endoscopic laser cordectomy for T1a glottic carcinoma. Eur Ann Otorhinolaryngol Head Neck Dis 2011;128:297–300Google Scholar
14The Department of Veterans Affairs Laryngeal Cancer Study Group. Induction chemotherapy plus radiation compared with surgery plus radiation in patients with advanced laryngeal cancer. N Engl J Med 1991;324:1685–90Google Scholar
15Lefebvre, JL, Chevalier, D, Luboinski, B, Kirkpatrick, A, Collette, L, Sahmoud, T. Larynx preservation in pyriform sinus cancer: preliminary results of a European Organization for Research and Treatment of Cancer phase III trial. EORTC Head and Neck Cancer Cooperative Group. J Natl Cancer Inst 1996;88:890–9Google Scholar
16Rao, DN, Shroff, PD, Chattopadhyay, G, Dinshaw, KA. Survival analysis of 5595 head and neck cancers –results of conventional treatment in a high-risk population. Br J Cancer 1998;77:1514–18Google Scholar
17Karatzanis, AD, Psychogios, G, Waldfahrer, F, Kapsreiter, M, Zenk, J, Velegrakis, GA. Management of locally advanced laryngeal cancer. J Otolaryngol Head Neck Surg 2014;43:4Google Scholar
18Hamilton, DW, McMeekin, PJ, Dyson, P, Robson, AK. Laryngeal cancer management in a small, rural, multidisciplinary team setting: 15-year review. J Laryngol Otol 2013;127:1203–7CrossRefGoogle Scholar
19Spiro, RH, Gallo, O, Shah, JP. Selective jugular node dissection in patients with squamous carcinoma of the larynx or pharynx. Am J Surg 1993;166:399–402Google Scholar
20Brazilian Head and Neck Cancer Study Group. End results of a prospective trial on elective lateral neck dissection vs type III modified radical neck dissection in the management of supraglottic and transglottic carcinomas. Head Neck 1999;21:694–702Google Scholar
21Kaplan, MJ, Johns, ME, McLean, WC, Fitz-Hugh, GS, Clark, DA, Boyd, JC. Prognostic factors and management. Laryngoscope 1983;93:725–8Google Scholar
22Ferlito, A, Silver, CE, Rinaldo, A, Smith, RV. Surgical treatment of the neck in cancer of the larynx. ORL J Otorhinolaryngol Relat Spec 2000;62:217–25Google Scholar
23Shi, RJ, Xu, CZ, Zhang, CP, Jiang, CY, Sun, YY, Yan, XJ et al. Outcomes of laryngectomy in elderly patients with laryngeal carcinoma. Genet Mol Res 2014;13:1955–63CrossRefGoogle ScholarPubMed
24Chen, AY, Schrag, N, Hao, Y, Flanders, WD, Kepner, J, Stewart, A et al. Changes in treatment of advanced laryngeal cancer 1985-2001. J Otolaryngol Head Neck Surg 2006;135:831–7Google Scholar
25Nunez-Batalla, F. Voice outcome after laser management of early glottic carcinoma (part A). In: Oswal, V, Remacle, M, eds. Principles and Practice of Lasers in Otorhinolaryngology and Head and Neck Surgery, 2nd edn.Amsterdam: Kugler Publications, 2014;207–22Google Scholar