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Value of autofluorescence bronchoscopy in patients with laryngeal cancer

Published online by Cambridge University Press:  09 November 2010

E Çetınkaya ,
B Veyseller ,
Y S Yildirim ,
F Aksoy ,
M A Özgül ,
A Gençoğlu  and
S Altin
E Çetınkaya
Affiliation:
Department of Chest Disease, Yedikule Chest Disease and Thoracic Surgery Education and Research Hospital, Istanbul, Turkey
B Veyseller
Affiliation:
Department of Otorhinolaryngology and Head and Neck Surgery, Haseki Research and Training Hospital, Istanbul, Turkey
Y S Yildirim*
Affiliation:
Department of Otorhinolaryngology and Head and Neck Surgery, Haseki Research and Training Hospital, Istanbul, Turkey
F Aksoy
Affiliation:
Department of Otorhinolaryngology and Head and Neck Surgery, Haseki Research and Training Hospital, Istanbul, Turkey
M A Özgül
Affiliation:
Department of Chest Disease, Yedikule Chest Disease and Thoracic Surgery Education and Research Hospital, Istanbul, Turkey
A Gençoğlu
Affiliation:
Department of Chest Disease, Yedikule Chest Disease and Thoracic Surgery Education and Research Hospital, Istanbul, Turkey
S Altin
Affiliation:
Department of Chest Disease, Yedikule Chest Disease and Thoracic Surgery Education and Research Hospital, Istanbul, Turkey
*
Dr Yavuz Selim Yıldırım, Haseki Egitim ve Arastirma Hastanesi, Kulak Burun Bogaz Klinigi, 34089 Fatih, Istanbul, Turkey Fax: +90 212 5103701 E-mail: dryavuzselim@yahoo.com
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Abstract

Background:

Patients with squamous cell carcinoma of the head and neck constitute a high risk group for synchronous and metachronous tumours.

Objective:

This study aimed to investigate the usefulness of white light and autofluorescence bronchoscopy in the evaluation of pre-malignant and early neoplastic lesions in patients with laryngeal cancer, who are at high risk of concomitant lung cancer.

Methods:

This prospective, cross-sectional study included 30 patients who had undergone total laryngectomy for squamous cell carcinoma of the larynx. The tracheobronchial system was investigated for the presence of pre-malignant and malignant lesions, using a combination of white light and autofluorescence bronchoscopy. Biopsies were obtained from areas with a pathological appearance, and histopathological studies were performed.

Results:

All patients had a permanent tracheostomy. Light and autofluorescence bronchoscopy indicated that the tracheobronchial system was normal in 11 patients. A total of 27 biopsies was taken from the remaining 19 patients, and revealed invasive squamous cell carcinoma in one patient and pre-malignant changes in six.

Conclusion:

Bronchoscopy is a valuable and practical tool for screening patients at high risk of lung cancer, and requires minimal intervention especially in patients with a permanent tracheostomy. Of the various bronchoscopic techniques becoming available, autofluorescence bronchoscopy shows promise for the detection of pre-invasive malignant changes of the tracheobronchial system in patients previously operated upon for laryngeal cancer.

Keywords

Lung NeoplasmsAutofluorescenceBronchoscopyHead And Neck NeoplasmsCarcinoma In SituLaryngectomy
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 125 , Issue 2 , February 2011 , pp. 181 - 187
Copyright
Copyright © JLO (1984) Limited 2010

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