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Anosmia in the first coronavirus disease 2019 outbreak in Europe: functional recovery after eight months

Part of: JLO Coronavirus Collection

Published online by Cambridge University Press:  26 February 2021

M Capelli  and
P Gatti
M Capelli*
Affiliation:
Department of Otolaryngology, Columbus Clinic Center, Milan, Italy
P Gatti
Affiliation:
Department of Otolaryngology, Columbus Clinic Center, Milan, Italy
*
Author for correspondence: Dr Marco Capelli, Department of Otolaryngology, Columbus Clinic Center, Via Michelangelo Buonarroti, 48, 20145Milan, Italy E-mail: info@otorinocremona.it
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Abstract

Background

Severe acute respiratory syndrome coronavirus-2 is a formidable virus, responsible for coronavirus disease 2019 and endowed with marked neurotropism. The damage it causes to the nervous system is manifold. The main neurological manifestation is anosmia. Olfactory damage is often transient, but there are no data reflecting an observational period of several months.

Objective

This study evaluated the trend of anosmia in patients affected by coronavirus disease 2019 in the eight months following diagnosis.

Methods

Fifty-five subjects who presented with symptoms suggestive of coronavirus disease 2019 and who developed anosmia, between the end of February and the beginning of March 2020, were investigated. The patients were interviewed after eight months to determine functional recovery and assess the degree of recovery.

Results

Ninety-one per cent of the population reported olfactory recovery and, of these, 53 per cent had total recovery after eight months. Females and younger age groups seem slightly advantaged in functional recovery. The elderly population appears to have excellent prospects for full functional recovery.

Conclusion

Anosmia represents a frequent neurological manifestation during coronavirus disease 2019. Fortunately, it is transient in most cases, and only a small percentage of patients affected by it report long-term functional deficits.

Keywords

AnosmiaSARS-CoVSmellOlfactionEpidemicsOutbreaks
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 135 , Issue 3 , March 2021 , pp. 224 - 228
Copyright
Copyright © The Author(s), 2021. Published by Cambridge University Press

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Footnotes

Dr M Capelli takes responsibility for the integrity of the content of the paper

References

Sohrabi, C, Alsafi, Z, O'Neill, N, Khan, M, Kerwan, A, Al-Jabir, A et al. World Health Organization declares global emergency: a review of the 2019 novel coronavirus (COVID-19). Int J Surg 2020;76:71–6CrossRefGoogle Scholar
Coronaviridae Study Group of the International Committee on Taxonomy of Viruses. The species severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2. Nat Microbiol 2020;5:536–44CrossRefGoogle Scholar
Capelli, M, Gatti, P. Anosmia and COVID-19 in south Lombardy: description of the first cases series in Europe. B-ENT 2020;16:86–90CrossRefGoogle Scholar
Cascella, M, Rajnik, M, Cuomo, A, Dulebohn, SC, Di Napoli, R. Features, evaluation, and treatment of coronavirus. In: StatPearls [Internet]. Treasure Island, FL: StatPearls Publishing, 2020Google ScholarPubMed
Van der Poel, N, Mansbach, AL, Loundon, N, Russell, J, Vanderveken, OM, Boudewyns, A. Challenges in pediatric otolaryngology in the COVID-19 pandemic: insights from current protocols and management strategies. B-ENT 2020;16:59–62CrossRefGoogle Scholar
Klopfenstein, T, Kadiane-Oussou, NJ, Toko, L, Royer, PY, Lepiller, Q, Gendrin, V et al. Features of anosmia in COVID-19. Med Mal Infect 2020;50:436–9CrossRefGoogle ScholarPubMed
Moein, ST, Hashemian, SMR, Mansourafshar, B, Khorram-Tousi, A, Tabarsi, P, Doty, RL. Smell dysfunction: a biomarker for COVID-19. Int Forum Allergy Rhinol 2020;10:944–55CrossRefGoogle ScholarPubMed
Otte, MS, Eckel, HNC, Poluschkin, L, Klussmann, JP, Luers, JC. Olfactory dysfunction in patients after recovering from COVID-19. Acta Otolaryngol 2020;140:1032–5CrossRefGoogle ScholarPubMed
Vroegop, AV, Eeckels, AS, Van Rompaey, V, Vanden Abeele, D, Schiappoli, M, Alobid, I et al. COVID-19 and olfactory dysfunction - an ENT perspective to the current COVID-19 pandemic. B-ENT 2020;16:81–5CrossRefGoogle Scholar
Lechien, JR, Chiesta-Estomba, CM, De Siati, DR, Horoi, M, Le Bon, SD, Rodriguez, A et al. Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicentre European study. Eur Arch Otorhinolaryngol 2020;277:2251–61CrossRefGoogle Scholar
Yan, CH, Faraji, F, Prajapati, DP, Boone, CE, DeConde, AS. Association of chemosensory dysfunction and Covid-19 in patients presenting with influenza-like symptoms. Int Forum Allergy Rhinol 2020;10:806–13CrossRefGoogle ScholarPubMed
Vaira, LA, Deiana, G, Fois, AG, Pirina, P, Madeddu, G, De Vito, A et al. Objective evaluation of anosmia and ageusia in COVID-19 patients: a single-center experience on 72 cases. Head Neck 2020;42:1252–8CrossRefGoogle ScholarPubMed
Bilinska, K, Butowt, R. Anosmia in COVID-19: a bumpy road to establishing a cellular mechanism. ACS Chem Neurosci 2020;11:2152–5CrossRefGoogle ScholarPubMed
Hopkins, C, Surda, P, Kumar, N. Presentation of new onset anosmia during the COVID-19 pandemic. Rhinology 2020;58:295–8CrossRefGoogle ScholarPubMed
Gane, SB, Kelly, C, Hopkins, C. Isolated sudden onset anosmia in COVID-19 infection. A novel syndrome? Rhinology 2020;58:299–301CrossRefGoogle ScholarPubMed
Hopkins, C, Surda, P, Whitehead, E, Kumar, BN. Early recovery following new onset anosmia during the COVID-19 pandemic - an observational cohort study. J Otolaryngol Head Neck Surg 2020;49:26CrossRefGoogle ScholarPubMed
Vaira, L, Hopkins, C, Sandison, A, Manca, A, Machouchas, N, Turilli, D et al. Olfactory epithelium histopathological findings in long-term coronavirus disease 2019 related anosmia. J Laryngol Otol 2020;134:1123–7CrossRefGoogle ScholarPubMed
Mazzatenta, A, Neri, G, D'Ardes, D, De Luca, C, Marinari, S, Porreca, E et al. Smell and taste in severe CoViD-19: self-reported vs. testing. Front Med (Lausanne) 2020;7:589409Google ScholarPubMed
Ahmed, MU, Hanif, M, Ali, MJ, Haider, MA, Kherani, D, Memon, GM et al. Neurological manifestations of COVID-19 (SARS-CoV-2): a review. Front Neurol 2020;11:518CrossRefGoogle ScholarPubMed
Mao, L, Jin, H, Wang, M, Hu, Y, Chen, S, He, Q et al. Neurologic manifestations of hospitalized patients with coronavirus disease 2019 in Wuhan, China. JAMA Neurol 2020;77:683–90CrossRefGoogle ScholarPubMed
Meng, X, Deng, Y, Dai, Z, Meng, Z. COVID-19 and anosmia: a review based on up-to-date knowledge. Am J Otolaryngol 2020;41:102581CrossRefGoogle ScholarPubMed
Zhao, Y, Zhao, Z, Wang, Y, Zhou, Y, Ma, Y, Zuo, W. Single-cell RNA expression profiling of ACE2, the receptor of SARS-CoV-2. Am J Respir Crit Care Med 2020;202:756–9CrossRefGoogle ScholarPubMed
Zheng, YY, Ma, YT, Zhang, JY, Xie, X. COVID-19 and the cardiovascular system. Nat Rev Cardiol 2020;17:259–60CrossRefGoogle ScholarPubMed
Freni, F, Meduri, A, Gazia, F, Nicastro, V, Galletti, C, Aragona, P et al. Symptomatology in head and neck district in coronavirus disease (COVID-19): a possible neuroinvasive action of SARS-CoV-2. Am J Otolaryngol 2020;41:102612CrossRefGoogle ScholarPubMed
Li, YC, Bai, WZ, Hashikawa, T. The neuroinvasive potential of SARS-CoV2 may be at least partially responsible for the respiratory failure of COVID-19 patients. J Med Virol 2020;92:552–5CrossRefGoogle Scholar
Avcı, H, Karabulut, B, Farasoglu, A, Boldaz, E, Evman, M. Relationship between anosmia and hospitalisation in patients with coronavirus disease 2019: an otolaryngological perspective. J Laryngol Otol 2020;134:710–16CrossRefGoogle ScholarPubMed