Hostname: page-component-78c5997874-lj6df Total loading time: 0 Render date: 2024-11-18T06:05:42.419Z Has data issue: false hasContentIssue false
  • English
  • Français

Neutrophil-to-lymphocyte ratio in patients with severe tinnitus: prospective, controlled clinical study

Published online by Cambridge University Press:  04 May 2015

I Ozbay ,
C Kahraman ,
H H Balikci ,
C Kucur ,
N K Kahraman ,
D P Ozkaya  and
F Oghan
I Ozbay*
Affiliation:
Department of Otorhinolaryngology, Dumlupınar University, Kutahya
C Kahraman
Affiliation:
Department of Internal Medicine, Dumlupınar University Evliya Celebi Education and Research Hospital, Kutahya
H H Balikci
Affiliation:
Department of Otorhinolaryngology, Susehri State Hospital, Sivas, Turkey
C Kucur
Affiliation:
Department of Otorhinolaryngology, Dumlupınar University, Kutahya
N K Kahraman
Affiliation:
Department of Internal Medicine, Dumlupınar University Evliya Celebi Education and Research Hospital, Kutahya
D P Ozkaya
Affiliation:
Department of Internal Medicine, Dumlupınar University Evliya Celebi Education and Research Hospital, Kutahya
F Oghan
Affiliation:
Department of Otorhinolaryngology, Dumlupınar University, Kutahya
*
Address for correspondence: Dr Isa Ozbay, Department of Otolaryngology, Medicine Faculty of Dumlupınar University, Kutahya, Turkey Fax: +9002742316673 E-mail: isaozbay@gmail.com
Get access Rights & Permissions [Opens in a new window]

Abstract

Objective:

To determine the relationship between severe tinnitus and inflammation using the neutrophil-to-lymphocyte ratio as a marker of stress.

Methods:

A total of 107 patients who had been suffering with severe tinnitus (tinnitus handicap inventory scale grades of 3–5) for at least 2 weeks were recruited. Patients underwent detailed ENT examinations and audiometric tests to exclude a relevant pathological cause of the tinnitus. Patients with systemic diseases, malignancy or inflammatory diseases that could alter neutrophil-to-lymphocyte ratio were excluded. A total of 107 age- and sex-matched healthy control participants were also recruited. Routine laboratory test results and neutrophil-to-lymphocyte ratio were compared between the patients and controls.

Results:

Lipid profile, liver function, white blood cell count, haemoglobin level, mean corpuscular volume, and vitamin B12 and folate levels were similar among the patients and controls. However, mean neutrophil-to-lymphocyte ratio was significantly higher among the patients than the controls (p < 0.05).

Conclusion:

The findings of this novel study suggest that neutrophil-to-lymphocyte ratio should be considered during the evaluation of tinnitus patients as a potential clinical marker of tinnitus. Further studies are required to verify the findings.

Keywords

TinnitusStressPhysiologicalClinical MarkerInflammation
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 129 , Issue 6 , June 2015 , pp. 544 - 547
Copyright
Copyright © JLO (1984) Limited 2015 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1Hoffman, HJ, Reed, GW. Epidemiology of tinnitus. In: Snow, JB, ed. Tinnitus: Theory and Management. Hamilton, Ontario: BC Decker, 2004;16–41Google Scholar
2Belli, H, Belli, S, Oktay, MF, Ural, C. Psychopathological dimensions of tinnitus and psychopharmacologic approaches in its treatment. Gen Hosp Psychiatry 2012;34:282–9CrossRefGoogle ScholarPubMed
3Gomaa, MA, Elmagd, MH, Elbadry, MM, Kader, RM. Depression, Anxiety and Stress Scale in patients with tinnitus and hearing loss. Eur Arch Otorhinolaryngol 2014;271:2177–84CrossRefGoogle ScholarPubMed
4Kim, DK, Chung, DY, Bae, SC, Park, KH, Yeo, SW, Park, SN. Diagnostic value and clinical significance of stress hormones in patients with tinnitus. Eur Arch Otorhinolaryngol 2014;271:2915–21CrossRefGoogle ScholarPubMed
5Arruda-Olson, AM, Reeder, GS, Bell, MR, Weston, SA, Roger, WL. Neutrophilia predicts death and heart failure after myocardial infarction: a community-based study. Circ Cardiovasc Qual Outcomes 2009;2:656–62CrossRefGoogle ScholarPubMed
6Tamhane, UU, Aneja, S, Montgomery, D, Rogers, EK, Eagle, KA, Gurm, HS. Association between admission neutrophil to lymphocyte ratio and outcomes in patients with acute coronary syndrome. Am J Cardiol 2008;102:653–7CrossRefGoogle ScholarPubMed
7Nunez, J, Nunez, E, Bodi, V, Sanchis, J, Minana, G, Mainar, L et al. Usefulness of the neutrophil to lymphocyte ratio in predicting long-term mortality in ST segment elevation myocardial infarction. Am J Cardiol 2008;101:747–52CrossRefGoogle ScholarPubMed
8Walsh, SR, Cook, EJ, Goulder, F, Justin, TA, Keeling, NJ. Neutrophil-lymphocyte ratio as a prognostic factor in colorectal cancer. J Surg Oncol 2005;91:181–4CrossRefGoogle ScholarPubMed
9Friedman, GD, Tekawa, I, Grimm, RH, Manolio, T, Shannon, SG, Sidney, S. The leucocyte count: correlates and relationship to coronary risk factors: the CARDIA study. Int J Epidemiol 1990;19:889–93CrossRefGoogle ScholarPubMed
10Turkmen, K, Guney, I, Yerlikaya, FH, Tonbul, HZ. The relationship between neutrophil-to-lymphocyte ratio and inflammation in end-stage renal disease patients. Ren Fail 2012;34:155–9CrossRefGoogle ScholarPubMed
11Mazurek, B, Haupt, H, Olze, H, Szczepek, AJ. Stress and tinnitus-from bedside to bench and back. Front Syst Neurosci 2012;6:47CrossRefGoogle ScholarPubMed
12Hinton, DE, Chhean, D, Pich, V, Hofman, SG, Barlow, DH. Tinnitus among Cambodian refugees: relationship to PTSD severity. J Trauma Stress 2006;19:541–6CrossRefGoogle ScholarPubMed
13Kreuzer, PM, Landgrebe, M, Schecklmann, M, Staudinger, S, Langguth, B; TRI Database Study Group. Trauma-associated tinnitus: audiological, demographic and clinical characteristics. PLoS One 2012;7:e45599CrossRefGoogle ScholarPubMed
14Doğan, M, Akyel, A, Bilgin, M, Erat, M, Çimen, T, Sunman, H et al. Can admission neutrophil to lymphocyte ratio predict infarct-related artery patency in ST-segment elevation myocardial infarction? Clin Appl Thromb Hemost 2015;21:172–6CrossRefGoogle ScholarPubMed
15Jin, Y, Ye, X, He, C, Zhang, B, Zhang, Y. Pretreatment neutrophil-to-lymphocyte ratio as predictor of survival for patients with metastatic nasopharyngeal carcinoma. Head Neck 2015;37:69–75CrossRefGoogle ScholarPubMed
16Seretis, C, Gourgiotis, S, Gemenetzis, G, Seretis, F, Lagoudianakis, E, Dimitrakopoulos, G. The significance of neutrophil/lymphocyte ratio as a possible marker of underlying papillary microcarcinomas in thyroidal goiters: a pilot study. Am J Surg 2013;205:691–6CrossRefGoogle ScholarPubMed