Hostname: page-component-78c5997874-4rdpn Total loading time: 0 Render date: 2024-11-19T14:11:22.790Z Has data issue: false hasContentIssue false
  • English
  • Français

A novel prognostic biomarker for recurrent aphthous stomatitis: calprotectin

Published online by Cambridge University Press:  09 July 2019

S Kayabasi  and
I Kuzucu
S Kayabasi*
Affiliation:
Department of ENT, Aksaray University Faculty of Medicine, Turkey
I Kuzucu
Affiliation:
Department of ENT, Aksaray University Faculty of Medicine, Turkey
*
Author for correspondence: Dr Serkan Kayabasi, Department of ENT, Faculty of Medicine, Aksaray University, Aksaray 68100, Turkey E-mail: drserkankayabasi@gmail.com Fax: +90 382 2119100
Get access Rights & Permissions [Opens in a new window]

Abstract

Objective

This study aims to investigate whether there is a correlation between serum calprotectin concentration and oral ulcer activity in patients with active recurrent aphthous stomatitis.

Method

This prospective, cross-sectional, historical cohort study included 52 patients (26 with active lesions and 26 with inactive lesions) with recurrent aphthous stomatitis and 27 healthy volunteers. The relationship between the groups was statistically evaluated in terms of serum calprotectin level and other inflammatory parameters.

Results

The median calprotectin value of the active lesion group (80.5 ng/ml) was significantly higher than that of the control group (55.4 ng/ml, p = 0.002). Furthermore, the median calprotectin value of the active lesion group was significantly higher than that of the inactive lesion group (72.5 ng/ml, p = 0.017).

Conclusion

In patients with recurrent aphthous stomatitis and active ulcer lesions, the serum calprotectin value can be used as a reliable and robust prognostic marker for inflammation.

Keywords

StomatitisAphthousLeukocyte L1 Antigen ComplexInflammation
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 133 , Issue 8 , August 2019 , pp. 691 - 695
Copyright
Copyright © JLO (1984) Limited, 2019 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Footnotes

Dr S Kayabasi takes responsibility for the integrity of the content of the paper

References

1Jurge, S, Kuffer, R, Scully, C, Porter, SR. Mucosal disease series. Number VI. Recurrent aphthous stomatitis. Oral Dis 2006;12:1–21Google Scholar
2Ślebioda, Z, Szponar, E, Kowalska, A. Etiopathogenesis of recurrent aphthous stomatitis and the role of immunologic aspects: literature review. Arch Immunol Ther Exp (Warsz) 2014;62:205–1510.1007/s00005-013-0261-yGoogle Scholar
3Greenberg, MS, Pinto, A. Etiology and management of recurrent aphthous stomatitis. Curr Infect Dis Rep 2003;5:194–8Google Scholar
4Pedersen, A, Ryder, LP. Gamma delta T-cell fraction of peripheral blood is increased in recurrent aphthous ulceration. Clin Immunol Immunopathol 1994;72:98–104.Google Scholar
5Ozler, GS. Zinc deficiency in patients with recurrent aphthous stomatitis: a pilot study. J Laryngol Otol 2014;128:531–3.Google Scholar
6El-Rıfai, W, Moskaluk, CA, Abdrabbo, MK, Harper, J, Yoshida, C, Riggins, GJ et al. Gastric cancers overexpress S100A calcium-binding proteins. Cancer Res 2002;62:6823–6Google Scholar
7Stříž, I, Trebichavský, I. Calprotectin—a pleiotropic molecule in acute and chronic inflammation. Physiol Res 2004;53:245–53Google Scholar
8Dale, I, Brandtzaeg, P. Expression of the epithelial L1 antigen as an immunohistochemical marker of squamous cell carcinoma of the lung. Histopathology 1989;14:493–50210.1111/j.1365-2559.1989.tb02185.xGoogle Scholar
9Mumcu, G, Sur, H, Inanc, N, Karacayli, U, Cimilli, H, Sisman, N et al. A composite index for determining the impact of oral ulcer activity in Behcet's disease and recurrent aphthous stomatitis. Journal Oral Pathol Med 2009;38:785–91Google Scholar
10Natah, SS, Häyrinen-Immonen, R, Hietanen, J, Patinen, P, Malmström, M, Savilahti, E et al. Increased density of lymphocytes bearing γ/δ T-cell receptors in recurrent aphthous ulceration (RAU). Int J Oral Maxillofac Surg 2000;29:375–80Google Scholar
11Porter, S, Scully, C. Aphthous stomatitis—an overview of aetiopathogenesis and management. Clin Exp Dermatol 1991;16:235–43Google Scholar
12Boussac, M, Garin, J. Calcium-dependent secretion in human neutrophils: a proteomic approach. Electrophoresis 2000;21:665–72Google Scholar
13Topuz, MF, Binnetoglu, A, Yumusakhuylu, AC, Sarı, M, Baglam, T, Gerin, F. Circulating calprotectin as a biomarker of laryngeal carcinoma. Eur Arch Otorhinolaryngol 2017;274:2499–504Google Scholar
14Arai, K, Teratani, T, Kuruto-Niwa, R, Yamada, T, Nozawa, R. S100A9 expression in invasive ductal carcinoma of the breast: S100A9 expression in adenocarcinoma is closely associated with poor tumour differentiation. Eur J Cancer 2004;40:1179–87Google Scholar
15Arai, K, Yamada, T, Nozawa, R. Immunohistochemical investigatigation of migration inhibitory factor-related protein (MRP)-14 expression in hepatocellular carcinoma. Med Oncol 2000;17:183–8Google Scholar
16Ozler, GS, Akoglu, E. The relationship between neutrophil to lymphocyte ratio and recurrent aphthous stomatitis. JCAM 2016;7:152–4Google Scholar
17Ekiz, O, Balta, I, Sen, BB, Rifaioglu, EN, Ergin, C, Balta, S et al. Mean platelet volume in recurrent aphthous stomatitis and Behçet disease. Angiology 2014;65:161–5Google Scholar
18Alan, S, Tuna, S, Türkoğlu, E. The relation of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and mean platelet volume with the presence and severity of Behcet's syndrome. Kaohsiung J Med Sci 2015;31:626–31Google Scholar
19Kristinsson, J, Roseth, A, Fagerhol, MK, Aadland, E, Schjonsby, H, Bormer, OP et al. Fecal calprotectin concentration in patients with colorectal carcinoma. Dis Colon Rectum 1998;41:316–2110.1007/BF02237485Google Scholar