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Electrohydrodynamic-jetting (EHD-jet) 3D-printed functionally graded scaffolds for tissue engineering applications

Published online by Cambridge University Press:  04 June 2018

Sanjairaj Vijayavenkataraman Open the ORCID record for Sanjairaj Vijayavenkataraman [Opens in a new window] ,
Shuo Zhang ,
Wen Feng Lu  and
Jerry Ying Hsi Fuh
Sanjairaj Vijayavenkataraman*
Affiliation:
Department of Mechanical Engineering, National University of Singapore, Singapore 117576, Singapore
Shuo Zhang
Affiliation:
Department of Mechanical Engineering, National University of Singapore, Singapore 117576, Singapore
Wen Feng Lu
Affiliation:
Department of Mechanical Engineering, National University of Singapore, Singapore 117576, Singapore
Jerry Ying Hsi Fuh
Affiliation:
Department of Mechanical Engineering, National University of Singapore, Singapore 117576, Singapore
*
a)Address all correspondence to this author. e-mail: vijayavenkataraman@u.nus.edu
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Abstract

Biomimicry is a desirable quality of tissue engineering scaffolds. While most of the scaffolds reported in the literature contain a single pore size or porosity, the native biological tissues such as cartilage and skin have a layered architecture with zone-specific pore size and mechanical properties. Thus, there is a need for functionally graded scaffolds (FGS). EHD-jet 3D printing is a high-resolution process and a variety of polymer solutions can be processed into 3D porous scaffolds at ease, overcoming the limitations of other 3D printing methods (SLS, stereolithography, and FDM) in terms of resolution and limited material choice. In this paper, a novel proof of concept study on fabrication of porous polycaprolactone-based FGS by using EHD-jet 3D printing technology is presented. Organomorphic scaffolds, multiculture systems, interfacial tissue engineering, and in vitro cancer metastasis models are some of the futuristic applications of these polymeric FGS.

Keywords

E-jettingfunctionally graded scaffoldsgradient porosityvariable porositytissue engineeringtissue engineering scaffoldsPCL scaffolds3D printing
Type
Invited Article
Information
Journal of Materials Research , Volume 33 , Issue 14: Focus Issue: 3D Printing of Biomaterials , 27 July 2018 , pp. 1999 - 2011
Copyright
Copyright © Materials Research Society 2018 

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References

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