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A novel and facile prepared wound dressing based on large expanded graphite worms

Published online by Cambridge University Press:  24 January 2019

Zhongqun Liu ,
Yishan Hao ,
Yijun Su ,
Yaojie Wei ,
Jingyun Wang ,
Hao Yan ,
Wanci Shen ,
Zhenghong Huang ,
Xiumei Wang  and
Lingyun Zhao
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Zhongqun Liu
Affiliation:
State Key Laboratory of New Ceramics and Fine Processing, School of Materials Science and Engineering, Tsinghua University, Beijing 100084, People’s Republic of China; and Key Laboratory of Advanced Materials of Ministry of Education of China, School of Materials Science and Engineering, Tsinghua University, Beijing 100084, Peoples R China
Yishan Hao
Affiliation:
Guanghua School of Stomatology, Hospital of Stomatology, Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong Province 510055, Peoples R China
Yijun Su*
Affiliation:
State Key Laboratory of New Ceramics and Fine Processing, School of Materials Science and Engineering, Tsinghua University, Beijing 100084, People’s Republic of China; and Key Laboratory of Advanced Materials of Ministry of Education of China, School of Materials Science and Engineering, Tsinghua University, Beijing 100084, Peoples R China
Yaojie Wei
Affiliation:
State Key Laboratory of New Ceramics and Fine Processing, School of Materials Science and Engineering, Tsinghua University, Beijing 100084, People’s Republic of China; and Key Laboratory of Advanced Materials of Ministry of Education of China, School of Materials Science and Engineering, Tsinghua University, Beijing 100084, Peoples R China
Jingyun Wang
Affiliation:
State Key Laboratory of New Ceramics and Fine Processing, School of Materials Science and Engineering, Tsinghua University, Beijing 100084, People’s Republic of China; and Key Laboratory of Advanced Materials of Ministry of Education of China, School of Materials Science and Engineering, Tsinghua University, Beijing 100084, Peoples R China
Hao Yan
Affiliation:
State Key Laboratory of New Ceramics and Fine Processing, School of Materials Science and Engineering, Tsinghua University, Beijing 100084, People’s Republic of China; and Key Laboratory of Advanced Materials of Ministry of Education of China, School of Materials Science and Engineering, Tsinghua University, Beijing 100084, Peoples R China
Wanci Shen
Affiliation:
Key Laboratory of Advanced Materials of Ministry of Education of China, School of Materials Science and Engineering, Tsinghua University, Beijing 100084, Peoples R China
Zhenghong Huang
Affiliation:
Key Laboratory of Advanced Materials of Ministry of Education of China, School of Materials Science and Engineering, Tsinghua University, Beijing 100084, Peoples R China
Xiumei Wang
Affiliation:
State Key Laboratory of New Ceramics and Fine Processing, School of Materials Science and Engineering, Tsinghua University, Beijing 100084, People’s Republic of China; and Key Laboratory of Advanced Materials of Ministry of Education of China, School of Materials Science and Engineering, Tsinghua University, Beijing 100084, Peoples R China
Lingyun Zhao*
Affiliation:
State Key Laboratory of New Ceramics and Fine Processing, School of Materials Science and Engineering, Tsinghua University, Beijing 100084, People’s Republic of China; and Key Laboratory of Advanced Materials of Ministry of Education of China, School of Materials Science and Engineering, Tsinghua University, Beijing 100084, Peoples R China
Xiaodan Sun*
Affiliation:
State Key Laboratory of New Ceramics and Fine Processing, School of Materials Science and Engineering, Tsinghua University, Beijing 100084, People’s Republic of China; and Key Laboratory of Advanced Materials of Ministry of Education of China, School of Materials Science and Engineering, Tsinghua University, Beijing 100084, Peoples R China
*
b)e-mail: zhaolingyun@mail.tsinghua.edu.cn
a)Address all correspondence to these authors. e-mail: sunxiaodan@mail.tsinghua.edu.cn
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Abstract

As rarely large flake graphite (9 mesh) was recently exploited in China, it was innovatively developed as the raw material to prepare a novel wound dressing based on large expanded graphite (EG) in this work. The EG worms were prepared in an easy oxidative intercalation and thermal expansion method. Afterward, chitosan was grafted onto the surface of EG by chemical modification, forming CS-EG worms. CS-EG sponge dressings were then obtained by pressing a number of CS-EG worms together by external force. Due to the porous structure and large specific surface area, the produced CS-EG sponges exhibited outstanding adsorption capacity for wound exudate. They could also promote blood coagulation by adsorbing the blood cells and proteins quickly and effectively, showing excellent hemostatic performance. The eminent performances and the simple preparation process ensure the great application potential of CS-EG as a dressing material. This is also the first time to report the application of the traditional carbon material, EG, to act as a dressing material after chemical modification.

Keywords

expanded graphitewound dressingsabsorption capacityhemostasischitosan modification
Type
Article
Information
Journal of Materials Research , Volume 34 , Issue 4 , 28 February 2019 , pp. 490 - 499
Copyright
Copyright © Materials Research Society 2019 

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