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Synthesis of gold nanoparticles resistant to pH and salt for biomedical applications; functional activity of organic amine

Published online by Cambridge University Press:  18 October 2016

Prem C. Pandey  and
Govind Pandey
Prem C. Pandey*
Affiliation:
Department of Chemistry, Indian Institute of Technology (Banaras Hindu University), Varanasi-221005, India
Govind Pandey
Affiliation:
BRD Medical College, Gorakhpur-273013, India
*
a)Address all correspondence to this author. e-mail: pcpandey.apc@iitbhu.ac.in
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Abstract

The potency of many biomedical applications of gold nanoparticles (AuNPs); i.e., (i) bioimaging, (ii) diagnostic, (iii) therapeutic, (iv) drug carriers, and (v) immunochemical properties; are limited due its sensitivity toward salt and pH allowing variation in nanogeometry during practical applications. Such limitations directed the synthesis of AuNPs having extreme salt and pH resistant ability which has been undertaken in current research program. It has been found that the pH and salt tolerance ability of AuNPs are dependent on the nature of reducing and stabilizing agents. The use of organic amine containing reagents, i.e., polyethylenimine, 3-aminopropyltrimethoxysilane, in the presence of formaldehyde is examined that allows controlled and rapid synthesis of AuNPs having salt and pH tolerance ability. The mechanism justifying these properties of as-made AuNPs are presented herein. These reagents not only allow the synthesis of monometallic nanoparticles (NPs) but also enable the synthesis of bimetallic and trimetallic NPs. The synthesis of Au–Ag/Ag–Au, Pd-Au/Ag@(PdAu) NPs are examined involving the contribution of organic amine.

Keywords

nanoscalebiomedicalbiomaterial
Type
Invited Feature Paper
Information
Journal of Materials Research , Volume 31 , Issue 21 , 14 November 2016 , pp. 3313 - 3323
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Copyright
Copyright © Materials Research Society 2016 

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Footnotes

Contributing Editor: Lennart Bergström

This paper has been selected as an Invited Feature Paper.

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