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Honey and curcumin loaded multilayered polyvinylalcohol/cellulose acetate electrospun nanofibrous mat for wound healing

Published online by Cambridge University Press:  27 March 2020

Mrunalini K. Gaydhane Open the ORCID record for Mrunalini K. Gaydhane [Opens in a new window] ,
Jaya S. Kanuganti  and
Chandra S. Sharma Open the ORCID record for Chandra S. Sharma [Opens in a new window]
Mrunalini K. Gaydhane*
Affiliation:
Creative and Advanced Research Based on Nanomaterials (CARBON) Laboratory, Department of Chemical Engineering, Indian Institute of Technology Hyderabad, Sangareddy, Telangana 502285, India
Jaya S. Kanuganti
Affiliation:
Creative and Advanced Research Based on Nanomaterials (CARBON) Laboratory, Department of Chemical Engineering, Indian Institute of Technology Hyderabad, Sangareddy, Telangana 502285, India
Chandra S. Sharma
Affiliation:
Creative and Advanced Research Based on Nanomaterials (CARBON) Laboratory, Department of Chemical Engineering, Indian Institute of Technology Hyderabad, Sangareddy, Telangana 502285, India
*
a)Address all correspondence to this author. e-mail: ch15resch11008@iith.ac.in
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Abstract

Bioactive dressings which can treat any kind of chronic or acute wounds and can fully replace the conventional gauzes and superabsorbent dressings have proven to be a future market of wound care products in recent times. These dressings are multifunctional, which can effectively combat the wound infection, remove the exudate, promote angiogenesis, and protect the wound from external trauma. Proper selection of bioactive and polymer defines its efficiency. Current research unveils the therapeutic efficacy of curcumin–honey-loaded multilayered polyvinyl alcohol/cellulose acetate electrospun nanofibrous mats as an interactive bioactive wound dressing material. Scanning electron microscopy and Fourier transform infrared spectroscopy analysis infers uniform encapsulation and chemical compatibility of herbal actives and polymer, inside the nanofibrous layers. The as-spun mat shows potential resistance towards Escherichia coli and ∼90% antioxidant activity against diphenyl-picrylhydrazyl (DPPH)–free radical. Additionally, water absorbency, water vapor transmission rate, and wettability analysis show quick and excellent absorption with controlled transmission of wound exudate.

Keywords

polymernanostructurebiomaterial
Type
Article
Information
Journal of Materials Research , Volume 35 , Issue 6 , 30 March 2020 , pp. 600 - 609
Copyright
Copyright © Materials Research Society 2020

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