The authors draw attention to the continuous arising of new remedies for and new methods of cure in epilepsy, and the as constant disappointment of our hopes which further trials of the new agents bring. In particular they make reference to the combined opium and bromide cure of Flechsig, which later developments and several recorded cases of death whilst under the treatment have brought into discredit. They point out that the epileptic seizures may, for various reasons, disappear for long periods—two to twenty-nine years, as the more recent statements of Sinkler make clear,—and the futility, therefore, of the attempts to demonstrate the curative value of drugs by observations extending over periods of three to four months, or at the most one year. In spite of these objections, however, they determined to make trial of the Toulouse-Richet method, so strongly had it been recommended.