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Five-year results for image-guided brachytherapy (IGBT) for cervical carcinoma: a report from single institute of Thailand

Published online by Cambridge University Press:  21 December 2016

Ekkasit Tharavichitkul ,
Somvilai Chakrabandhu ,
Pitchayaponne Klunklin ,
Wimrak Onchan ,
Bongkot Jia-Mahasap ,
Suwapim Janla-or ,
Damrongsak Tippanya ,
Wannapa Nobnop ,
Somsak Wanwilairat  and
Nantaka Pukanhaphan
...Show all authors
Ekkasit Tharavichitkul*
Affiliation:
The Division of Radiation Oncology, Department of Radiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
Somvilai Chakrabandhu
Affiliation:
The Division of Radiation Oncology, Department of Radiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
Pitchayaponne Klunklin
Affiliation:
The Division of Radiation Oncology, Department of Radiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
Wimrak Onchan
Affiliation:
The Division of Radiation Oncology, Department of Radiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
Bongkot Jia-Mahasap
Affiliation:
The Division of Radiation Oncology, Department of Radiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
Suwapim Janla-or
Affiliation:
The Division of Radiation Oncology, Department of Radiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
Damrongsak Tippanya
Affiliation:
The Division of Radiation Oncology, Department of Radiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
Wannapa Nobnop
Affiliation:
The Division of Radiation Oncology, Department of Radiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
Somsak Wanwilairat
Affiliation:
The Division of Radiation Oncology, Department of Radiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
Nantaka Pukanhaphan
Affiliation:
The Division of Radiation Oncology, Department of Radiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
Razvan M. Galalae
Affiliation:
Faculty of Medicine, Christian-Albrechts-University, Kiel, Germany Department of Radio-Oncology, Evangelical Clinics, Gelsenkirchen, Germany
Imjai Chitapanarux
Affiliation:
The Division of Radiation Oncology, Department of Radiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
*
Correspondence to: Ekkasit Tharavichitkul, The Division of Radiation Oncology, Department of Radiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand. Tel: +66 85 0361113 Fax: +66 053 945491. Email: paan_31@hotmail.com
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Abstract

Aim

To report of long-term results and toxicity profiles using image-guided brachytherapy (IGBT) combined with whole pelvic radiation therapy (WPRT) for cervical carcinoma.

Materials and Methods

In total, 52 patients with locally advanced cervical carcinoma were enrolled into the study. WPRT was used to treat the clinical target volume (CTV) with a dose of 45–50·4 Gy in 23–28 fractions. IGBT using computed tomography was performed at the dose of 6·5–7 Gy×4 fractions to the minimum dose covering 90% of target volume (D90) of high-risk clinical target volume (HR-CTV).

Results

The mean cumulative dose in equivalent doses of 2 Gy for the D90 of HR-CTV, dose at 2% at refereed volume (D2cc) of bladder, D2cc of rectum and D2cc of sigmoid colon were 92·4, 87·9, 69·6, and 72 Gy, respectively. At the median follow-up time of 61 months, the 5-year local control, disease-free survival, and overall survival rates were 96·2, 75 and 84·6% respectively. Two patients (3·8%) developed grade 3–4 gastrointestinal and two patients (3·8%) developed grade 3–4 genitourinal toxicities.

Conclusion

The combination of WPRT plus IGBT showed very promising long-term results with excellent local control and toxicity profiles.

Keywords

cervical carcinomaimage-guided brachytherapylong-termresults
Type
Original Articles
Information
Journal of Radiotherapy in Practice , Volume 16 , Issue 1 , March 2017 , pp. 38 - 45
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Copyright
© Cambridge University Press 2016 

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