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Effect of LINAC-based postoperative radiotherapy on local control and survival in patients with non-small cell lung cancer

Published online by Cambridge University Press:  18 January 2017

Sare Cecen ,
Ali A. Yavuz ,
Yigit Cecen ,
Evrim Duman ,
Beyza S. Ozdemir  and
Melek G. Aksu
Sare Cecen*
Affiliation:
Department of Radiation Oncology, Antalya Education and Research Hospital, Antalya, Turkey
Ali A. Yavuz
Affiliation:
Department of Radiation Oncology, Akdeniz University School of Medicine, Antalya, Turkey
Yigit Cecen
Affiliation:
Department of Radiation Oncology, Akdeniz University School of Medicine, Antalya, Turkey
Evrim Duman
Affiliation:
Department of Radiation Oncology, Antalya Education and Research Hospital, Antalya, Turkey
Beyza S. Ozdemir
Affiliation:
Department of Radiation Oncology, Akdeniz University School of Medicine, Antalya, Turkey
Melek G. Aksu
Affiliation:
Department of Radiation Oncology, Akdeniz University School of Medicine, Antalya, Turkey
*
Correspondence to: Sare Cecen, Antalya Egitim ve Arastirma Hastanesi, Radyasyon Onkolojisi Klinigi, Varlik Mh., Kazim Karabekir Caddesi, 07100, Soguksu, Muratpasa, Antalya, Turkey. Tel: +90 530 5546448. Fax: +90 242 2373014. E-mail: dr_sare81@hotmail.com
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Abstract

Aim

To perform a retrospective analysis of survival, local–regional control and the effect of prognostic factors in 61 non-small cell lung cancer patients who were treated with postoperative radiotherapy (PORT) by a linear accelerator (LINAC).

Material and methods

A total of 50–66 Gy PORT with a fractional dose of 1·8–2 Gy was administered to 24 patients (24·5%) for surgical margin positivity, 33 patients (54%) for mediastinal lymph node involvement and 13 patients (21·5%) for both mediastinal lymph node involvement and positive surgical margins.

Results

Median follow-up was 17 months, and the median survival and median distant metastasis-free survival were 25 and 19 months, respectively. Local-regional progression was observed in 10 patients (16·4%). Treatment modality (2D/3D) (p=0·021), tumour size >4 cm (p=0·004), surgical margin positivity (p=0·001), and left lung localisation of the tumour (p≤0·05) were the prognostic factors in terms of survival.

Conclusions

A survey of the literature shows that, without PORT, local recurrence or progression rates increase while overall survival rates decrease. In this study, only patients with PORT are studied and the results show that the local progression and overall survival rates are comparable with literature of LINAC-based PORT. In the case of overall survival, 3D treatment shows better results than 2D treatment modality.

Keywords

linear accelerator (LINAC)non-small cell lung cancer (NSCLC)postoperative radiotherapy (PORT)
Type
Original Articles
Information
Journal of Radiotherapy in Practice , Volume 16 , Issue 2 , June 2017 , pp. 171 - 176
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Copyright
© Cambridge University Press 2017 

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