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Is the proton–boron fusion therapy effective?

Published online by Cambridge University Press:  16 March 2020

Navid Khaledi Open the ORCID record for Navid Khaledi [Opens in a new window] ,
Xufei Wang ,
Roghiye B. Hosseinabadi  and
Farhad Samiei
Navid Khaledi*
Affiliation:
Institute of Modern Physics, Fudan University, Shanghai200433, China Key Laboratory of Nuclear Physics and Ion-Beam Application (MOE), Fudan University, Shanghai200433, China
Xufei Wang
Affiliation:
Institute of Modern Physics, Fudan University, Shanghai200433, China Key Laboratory of Nuclear Physics and Ion-Beam Application (MOE), Fudan University, Shanghai200433, China
Roghiye B. Hosseinabadi
Affiliation:
Department of Environmental Health, Khoy University of Medical Science, Khoy, Iran
Farhad Samiei
Affiliation:
Radiation Oncology Department, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran
*
Author for correspondence: Navid Khaledi, Institute of Modern Physics, Fudan University, Shanghai200433, China. Tel: +86-13162274707. E-mail: khaledi@fudan.educn
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Abstract

Introduction:

In the recent years, some publications (mainly from one group of authors) have dealt with the effectiveness of proton–boron fusion therapy (PBFT). This theory is based on the Q-value of three produced α particles in the reaction of protons with boron (11B). They claim that this reaction significantly increases the absorbed dose in the target volume. However, the current study would re-evaluate their method to show if PBFT is really effective.

Methods and materials:

A parallel 80-MeV proton beam was irradiated on a water medium in a cubic boron uptake region (BUR). The two-dimensional dose distribution and percentage depth dose of protons, alphas and all particles were calculated using tally F6 and mesh-tallies by Monte Carlo N Particle Transport code.

Results:

The results not only showed that the dose enhancement in BUR is neglectable but also the higher density of BUR in comparison with water led to decrement of dose in this region. Because of low cross section of boron for proton beam (<100 mb), the α particles’ dose is 1,000 times lower than the proton dose.

Conclusions:

The physical aspects and the simulation results did not show any effectiveness of the PBFT for proton therapy dose enhancement.

Keywords

boronfusion therapyPBFTproton therapy
Type
Original Article
Information
Journal of Radiotherapy in Practice , Volume 20 , Issue 2 , June 2021 , pp. 153 - 157
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Copyright
© The Author(s), 2020. Published by Cambridge University Press

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