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Brain Cortical Thickness and Surface Area Correlates of Neurocognitive Performance in Patients with Schizophrenia, Bipolar Disorder, and Healthy Adults

Published online by Cambridge University Press:  03 October 2011

C.B. Hartberg ,
K. Sundet ,
L.M. Rimol ,
U.K. Haukvik ,
E.H. Lange ,
R. Nesvåg ,
A.M. Dale ,
I. Melle ,
O.A. Andreassen  and
I. Agartz
C.B. Hartberg*
Affiliation:
Institute of Clinical Medicine, Psychiatry Section, University of Oslo, Norway
K. Sundet
Affiliation:
Department of Psychology, University of Oslo, Norway Division of Mental Health and Addiction, Psychosis Research Unit, Oslo University Hospital, Norway
L.M. Rimol
Affiliation:
Institute of Clinical Medicine, Psychiatry Section, University of Oslo, Norway
U.K. Haukvik
Affiliation:
Institute of Clinical Medicine, Psychiatry Section, University of Oslo, Norway Department of Psychiatry, Diakonhjemmet Hospital, Oslo, Norway
E.H. Lange
Affiliation:
Institute of Clinical Medicine, Psychiatry Section, University of Oslo, Norway Department of Psychiatry, Diakonhjemmet Hospital, Oslo, Norway
R. Nesvåg
Affiliation:
Institute of Clinical Medicine, Psychiatry Section, University of Oslo, Norway Department of Psychiatry, Diakonhjemmet Hospital, Oslo, Norway
A.M. Dale
Affiliation:
Division of Mental Health and Addiction, Psychosis Research Unit, Oslo University Hospital, Norway Department of Neurosciences, University of California San Diego, La Jolla, California Department of Radiology, University of California San Diego, La Jolla, California
I. Melle
Affiliation:
Institute of Clinical Medicine, Psychiatry Section, University of Oslo, Norway Division of Mental Health and Addiction, Psychosis Research Unit, Oslo University Hospital, Norway
O.A. Andreassen
Affiliation:
Institute of Clinical Medicine, Psychiatry Section, University of Oslo, Norway Division of Mental Health and Addiction, Psychosis Research Unit, Oslo University Hospital, Norway
I. Agartz
Affiliation:
Institute of Clinical Medicine, Psychiatry Section, University of Oslo, Norway Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway
*
Correspondence and reprint requests to: Cecilie Bhandari Hartberg, P.O. Box 85, Vinderen, University of Oslo, N-0319 Oslo, Norway. E-mail: c.b.hartberg@medisin.uio.no
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Abstract

Relationships between cortical brain structure and neurocognitive functioning have been reported in schizophrenia, but findings are inconclusive, and only a few studies in bipolar disorder have addressed this issue. This is the first study to directly compare relationships between cortical thickness and surface area with neurocognitive functioning in patients with schizophrenia (n = 117) and bipolar disorder (n = 121) and healthy controls (n = 192). MRI scans were obtained, and regional cortical thickness and surface area measurements were analyzed for relationships with test scores from 6 neurocognitive domains. In the combined sample, cortical thickness in the right rostral anterior cingulate was inversely related to working memory, and cortical surface area in four frontal and temporal regions were positively related to neurocognitive functioning. A positive relationship between left transverse temporal thickness and processing speed was specific to schizophrenia. A negative relationship between right temporal pole thickness and working memory was specific to bipolar disorder. In conclusion, significant cortical structure/function relationships were found in a large sample of healthy controls and patients with schizophrenia or bipolar disorder. The differences that were found between schizophrenia and bipolar may indicate differential relationship patterns in the two disorders, which may be of relevance for understanding the underlying pathophysiology. (JINS, 2011, 17, 1080–1093)

Keywords

MRINeuropsychological testsCerebral cortexBrain structureCognitionBrain mapping
Type
Regular Articles
Information
Journal of the International Neuropsychological Society , Volume 17 , Issue 6 , November 2011 , pp. 1080 - 1093
Copyright
Copyright © The International Neuropsychological Society 2011

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References

Antonova, E., Kumari, V., Morris, R., Halari, R., Anilkumar, A., Mehrotra, R., Sharma, T. (2005). The relationship of structural alterations to cognitive deficits in schizophrenia: A voxel-based morphometry study. Biological Psychiatry, 58(6), 457–467.CrossRefGoogle ScholarPubMed
Arnone, D., Cavanagh, J., Gerber, D., Lawrie, S.M., Ebmeier, K.P., McIntosh, A.M. (2009). Magnetic resonance imaging studies in bipolar disorder and schizophrenia: Meta-analysis. British Journal of Psychiatry, 195(3), 194–201.CrossRefGoogle ScholarPubMed
Barch, D.M. (2009). Neuropsychological abnormalities in schizophrenia and major mood disorders: Similarities and differences. Current Psychiatry Reports, 11(4), 313–319.CrossRefGoogle ScholarPubMed
Bearden, C.E., Hoffman, K.M., Cannon, T.D. (2001). The neuropsychology and neuroanatomy of bipolar affective disorder: A critical review. Bipolar Disorder, 3(3), 106–150.CrossRefGoogle ScholarPubMed
Benes, F.M. (2010). Amygdalocortical circuitry in schizophrenia: From circuits to molecules. Neuropsychopharmacology, 35(1), 239–257.CrossRefGoogle ScholarPubMed
Bonilha, L., Molnar, C., Horner, M.D., Anderson, B., Forster, L., George, M.S., Nahas, Z. (2008). Neurocognitive deficits and prefrontal cortical atrophy in patients with schizophrenia. Schizophrenia Research, 101(1–3), 142–151.CrossRefGoogle ScholarPubMed
Bora, E., Fornito, A., Yucel, M., Pantelis, C. (2010). Voxelwise meta-analysis of gray matter abnormalities in bipolar disorder. Biological Psychiatry, 67(11), 1097–1105.CrossRefGoogle ScholarPubMed
Bora, E., Yucel, M., Pantelis, C. (2009). Cognitive endophenotypes of bipolar disorder: A meta-analysis of neuropsychological deficits in euthymic patients and their first-degree relatives. Journal of Affective Disorder, 113(1–2), 1–20.CrossRefGoogle ScholarPubMed
Brem, S., Bucher, K., Halder, P., Summers, P., Dietrich, T., Martin, E., Brandeis, D. (2006). Evidence for developmental changes in the visual word processing network beyond adolescence. Neuroimage, 29(3), 822–837.CrossRefGoogle ScholarPubMed
Buckner, R.L., Head, D., Parker, J., Fotenos, A.F., Marcus, D., Morris, J.C., Snyder, A.Z. (2004). A unified approach for morphometric and functional data analysis in young, old, and demented adults using automated atlas-based head size normalization: Reliability and validation against manual measurement of total intracranial volume. Neuroimage, 23(2), 724–738.CrossRefGoogle ScholarPubMed
Chumakov, I., Blumenfeld, M., Guerassimenko, O., Cavarec, L., Palicio, M., Abderrahim, H., Cohen, D. (2002). Genetic and physiological data implicating the new human gene G72 and the gene for D-amino acid oxidase in schizophrenia. Proceedings of the National Academy of Sciences of the United States of America, 99(21), 13675–13680.CrossRefGoogle ScholarPubMed
Cohen, J. (1988). Statistical power analysis for the behavioral sciences. Hillsdale, NJ: Erlbaum.Google Scholar
Conklin, H.M., Curtis, C.E., Katsanis, J., Iacono, W.G. (2000). Verbal working memory impairment in schizophrenia patients and their first-degree relatives: Evidence from the digit span task. American Journal of Psychiatry, 157(2), 275–277.CrossRefGoogle ScholarPubMed
Crespo-Facorro, B., Roiz-Santianez, R., Perez-Iglesias, R., Rodriguez-Sanchez, J.M., Mata, I., Tordesillas-Gutierrez, D., Vazquez-Barquero, J.L. (2011). Global and regional cortical thinning in first-episode psychosis patients: Relationships with clinical and cognitive features. Psychological Medicine, 41, 1449–1460.CrossRefGoogle ScholarPubMed
Dale, A.M., Fischl, B., Sereno, M.I. (1999). Cortical surface-based analysis. I. Segmentation and surface reconstruction. Neuroimage, 9(2), 179–194.CrossRefGoogle ScholarPubMed
Delis, D.C., Kaplan, E., Kramer, J. (2005). The Delis-Kaplan Executive Function System (D-KEFS). Norwegian manual supplement. Stockholm: Pearson Assessment.Google Scholar
Delis, D., Kramer, J., Kaplan, E., Ober, B.A. (2004). California Verbal Learning Test – Second edition (CVLT-II). Norwegian manual supplement. Stockhom: Pearson Assessment.Google Scholar
Desikan, R.S., Segonne, F., Fischl, B., Quinn, B.T., Dickerson, B.C., Blacker, D., Killiany, R.J. (2006). An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest. Neuroimage, 31(3), 968–980.CrossRefGoogle ScholarPubMed
Devinsky, O., Morrell, M.J., Vogt, B.A. (1995). Contributions of anterior cingulate cortex to behaviour. Brain, 118(Pt 1), 279–306.CrossRefGoogle ScholarPubMed
Dickerson, B.C., Fenstermacher, E., Salat, D.H., Wolk, D.A., Maguire, R.P., Desikan, R., Fischl, B. (2008). Detection of cortical thickness correlates of cognitive performance: Reliability across MRI scan sessions, scanners, and field strengths. Neuroimage, 39(1), 10–18.CrossRefGoogle ScholarPubMed
Ellison-Wright, I., Bullmore, E. (2010). Anatomy of bipolar disorder and schizophrenia: A meta-analysis. Schizophrenia Research, 117(1), 1–12.CrossRefGoogle ScholarPubMed
Engh, J.A., Friis, S., Birkenaes, A.B., Jonsdottir, H., Klungsoyr, O., Ringen, P.A., Andreassen, O.A. (2010). Delusions are associated with poor cognitive insight in schizophrenia. Schizophrenia Bulletin, 36(4), 830–835.CrossRefGoogle ScholarPubMed
First, M.B. (2002). Structured clinical interview for DSM-IV-TR Axis I disorders. Research Version, Non-patient Edition (SCID-I/NP). New York: Biometrics Research, New York State Psychiatric Institute.Google Scholar
Fischl, B., Dale, A.M. (2000). Measuring the thickness of the human cerebral cortex from magnetic resonance images. Proceedings of the National Academy of Sciences of the United States of America, 97(20), 11050–11055.CrossRefGoogle ScholarPubMed
Fischl, B., van der Kouwe, A., Destrieux, C., Halgren, E., Segonne, F., Salat, D.H., Dale, A.M. (2004). Automatically parcellating the human cerebral cortex. Cerebral Cortex, 14(1), 11–22.CrossRefGoogle ScholarPubMed
Fornito, A., Yucel, M., Pantelis, C. (2009). Reconciling neuroimaging and neuropathological findings in schizophrenia and bipolar disorder. Current Opinion in Psychiatry, 22(3), 312–319.CrossRefGoogle ScholarPubMed
Fornito, A., Yucel, M., Wood, S., Stuart, G.W., Buchanan, J.A., Proffitt, T., Pantelis, C. (2004). Individual differences in anterior cingulate/paracingulate morphology are related to executive functions in healthy males. Cerebral Cortex, 14(4), 424–431.CrossRefGoogle ScholarPubMed
Glahn, D.C., Laird, A.R., Ellison-Wright, I., Thelen, S.M., Robinson, J.L., Lancaster, J.L., Fox, P.T. (2008). Meta-analysis of gray matter anomalies in schizophrenia: Application of anatomic likelihood estimation and network analysis. Biological Psychiatry, 64(9), 774–781.CrossRefGoogle ScholarPubMed
Goldman, A.L., Pezawas, L., Mattay, V.S., Fischl, B., Verchinski, B.A., Chen, Q., Meyer-Lindenberg, A. (2009). Widespread reductions of cortical thickness in schizophrenia and spectrum disorders and evidence of heritability. Archives of General Psychiatry, 66(5), 467–477.CrossRefGoogle ScholarPubMed
Green, M.F. (2006). Cognitive impairment and functional outcome in schizophrenia and bipolar disorder. Journal of Clinical Psychiatry, 67(Suppl 9), 3–8.Google ScholarPubMed
Gur, R.E., Cowell, P., Turetsky, B.I., Gallacher, F., Cannon, T., Bilker, W., Gur, R.C. (1998). A follow-up magnetic resonance imaging study of schizophrenia. Relationship of neuroanatomical changes to clinical and neurobehavioral measures. Archives of General Psychiatry, 55(2), 145–152.CrossRefGoogle ScholarPubMed
Gutierrez-Galve, L., Wheeler-Kingshott, C.A., Altmann, D.R., Price, G., Chu, E.M., Leeson, V.C., Ron, M.A. (2010). Changes in the frontotemporal cortex and cognitive correlates in first-episode psychosis. Biological Psychiatry, 68(1), 51–60.CrossRefGoogle ScholarPubMed
Habets, P., Marcelis, M., Gronenschild, E., Drukker, M., van Os, J. (2010). Reduced cortical thickness as an outcome of differential sensitivity to environmental risks in schizophrenia. Biological Psychiatry, 69, 487–494 doi:S0006-3223(10)00844-9 [pii];10.1016/j.biopsych.2010.08.010CrossRefGoogle ScholarPubMed
Hartberg, C.B., Lawyer, G., Nyman, H., Jonsson, E.G., Haukvik, U.K., Saetre, P., Agartz, I. (2010). Investigating relationships between cortical thickness and cognitive performance in patients with schizophrenia and healthy adults. Psychiatry Research, 182(2), 123–133.CrossRefGoogle ScholarPubMed
Hattori, E., Liu, C., Badner, J.A., Bonner, T.I., Christian, S.L., Maheshwari, M., Gershon, E.S. (2003). Polymorphisms at the G72/G30 gene locus, on 13q33, are associated with bipolar disorder in two independent pedigree series. American Journal of Human Genetics, 72(5), 1131–1140.CrossRefGoogle ScholarPubMed
Heinrichs, R.W., Zakzanis, K.K. (1998). Neurocognitive deficit in schizophrenia: A quantitative review of the evidence. Neuropsychology, 12(3), 426–445.CrossRefGoogle ScholarPubMed
Jabben, N., Arts, B., van Os, J., Krabbendam, L. (2010). Neurocognitive functioning as intermediary phenotype and predictor of psychosocial functioning across the psychosis continuum: Studies in schizophrenia and bipolar disorder. Journal of Clinical Psychiatry, 71(6), 764–774.CrossRefGoogle ScholarPubMed
Kay, S.R., Fiszbein, A., Opler, L.A. (1987). The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophrenia Bulletin, 13(2), 261–276.CrossRefGoogle ScholarPubMed
Kremen, W.S., Prom-Wormley, E., Panizzon, M.S., Eyler, L.T., Fischl, B., Neale, M.C., Fennema-Notestine, C. (2010). Genetic and environmental influences on the size of specific brain regions in midlife: The VETSA MRI study. Neuroimage, 49(2), 1213–1223.CrossRefGoogle ScholarPubMed
Kunugi, H., Vallada, H.P., Sham, P.C., Hoda, F., Arranz, M.J., Li, T., Collier, D.A. (1997). Catechol-O-methyltransferase polymorphisms and schizophrenia: A transmission disequilibrium study in multiply affected families. Psychiatric Genetics, 7(3), 97–101.CrossRefGoogle ScholarPubMed
Kuperberg, G.R., Broome, M.R., McGuire, P.K., David, A.S., Eddy, M., Ozawa, F., Fischl, B. (2003). Regionally localized thinning of the cerebral cortex in schizophrenia. Archives of General Psychiatry, 60(9), 878–888.CrossRefGoogle ScholarPubMed
Lewandowski, K.E., Cohen, B.M., Ongur, D. (2011). Evolution of neuropsychological dysfunction during the course of schizophrenia and bipolar disorder. Psychological Medicine, 41(2), 225–241.CrossRefGoogle ScholarPubMed
Lezak, M.D. (1995). Neuropsychological assessment (3rd ed.). New York: Oxford University Press.Google Scholar
Lichtenstein, P., Yip, B.H., Bjork, C., Pawitan, Y., Cannon, T.D., Sullivan, P.F., Hultman, C.M. (2009). Common genetic determinants of schizophrenia and bipolar disorder in Swedish families: A population-based study. Lancet, 373(9659), 234–239.CrossRefGoogle ScholarPubMed
Lyoo, I.K., Sung, Y.H., Dager, S.R., Friedman, S.D., Lee, J.Y., Kim, S.J., Kim, N., Renshaw, P.F. (2006). Regional cerebral cortical thinning in bipolar disorder. Bipolar Disorder, 8(1), 65–74.CrossRefGoogle ScholarPubMed
Maier, W., Hofgen, B., Zobel, A., Rietschel, M. (2005). Genetic models of schizophrenia and bipolar disorder: Overlapping inheritance or discrete genotypes? European Archives of Psychiatry and Clinical Neuroscience, 255(3), 159–166.CrossRefGoogle ScholarPubMed
Matsui, M., Suzuki, M., Zhou, S.Y., Takahashi, T., Kawasaki, Y., Yuuki, H., Kurachi, M. (2008). The relationship between prefrontal brain volume and characteristics of memory strategy in schizophrenia spectrum disorders. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 32(8), 1854–1862.CrossRefGoogle ScholarPubMed
Minatogawa-Chang, T.M., Schaufelberger, M.S., Ayres, A.M., Duran, F.L., Gutt, E.K., Murray, R.M., Busatto, G.F. (2009). Cognitive performance is related to cortical grey matter volumes in early stages of schizophrenia: A population-based study of first-episode psychosis. Schizophrenia Research, 113(2–3), 200–209.CrossRefGoogle ScholarPubMed
Murray, R.M., Sham, P., van Os, J., Zanelli, J., Cannon, M., McDonald, C. (2004). A developmental model for similarities and dissimilarities between schizophrenia and bipolar disorder. Schizophrenia Research, 71(2–3), 405–416.CrossRefGoogle ScholarPubMed
Navari, S., Dazzan, P. (2009). Do antipsychotic drugs affect brain structure? A systematic and critical review of MRI findings. Psychological Medicine, 39(11), 1763–1777.CrossRefGoogle ScholarPubMed
Nesvag, R., Lawyer, G., Varnas, K., Fjell, A.M., Walhovd, K.B., Frigessi, A., Agartz, I. (2008). Regional thinning of the cerebral cortex in schizophrenia: Effects of diagnosis, age and antipsychotic medication. Schizophrenia Research, 98(1–3), 16–28.CrossRefGoogle ScholarPubMed
Neves-Pereira, M., Mundo, E., Muglia, P., King, N., Macciardi, F., Kennedy, J.L. (2002). The brain-derived neurotrophic factor gene confers susceptibility to bipolar disorder: Evidence from a family-based association study. American Journal of Human Genetics, 71(3), 651–655.CrossRefGoogle ScholarPubMed
Panizzon, M.S., Fennema-Notestine, C., Eyler, L.T., Jernigan, T.L., Prom-Wormley, E., Neale, M., Kremen, W.S. (2009). Distinct genetic influences on cortical surface area and cortical thickness. Cerebral Cortex, 19(11), 2728–2735.CrossRefGoogle ScholarPubMed
Premkumar, P., Kumari, V., Corr, P.J., Fannon, D., Sharma, T. (2008). Neuropsychological function-brain structure relationships and stage of illness: An investigation into chronic and first-episode schizophrenia. Psychiatry Research, 162(3), 195–204.CrossRefGoogle ScholarPubMed
Rakic, P. (1988). Specification of cerebral cortical areas. Science, 241(4862), 170–176.CrossRefGoogle ScholarPubMed
Rimol, L.M., Hartberg, C.B., Nesvag, R., Fennema-Notestine, C., Hagler, D.J. Jr., Pung, C.J., Agartz, I. (2010). Cortical thickness and subcortical volumes in schizophrenia and bipolar disorder. Biological Psychiatry, 68(1), 41–50.CrossRefGoogle ScholarPubMed
Rosa, A., Cuesta, M.J., Fatjo-Vilas, M., Peralta, V., Zarzuela, A., Fananas, L. (2006). The Val66Met polymorphism of the brain-derived neurotrophic factor gene is associated with risk for psychosis: Evidence from a family-based association study. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 141B(2), 135–138.CrossRefGoogle ScholarPubMed
Rund, B.R. (1998). A review of longitudinal studies of cognitive functions in schizophrenia patients. Schizophrenia Bulletin, 24(3), 425–435.CrossRefGoogle ScholarPubMed
Rusch, N., Spoletini, I., Wilke, M., Bria, P., Di Paola, M., Di Iulio, F., Spalletta, G. (2007). Prefrontal-thalamic-cerebellar gray matter networks and executive functioning in schizophrenia. Schizophrenia Research, 93(1–3), 79–89.CrossRefGoogle ScholarPubMed
Sanfilipo, M., Lafargue, T., Rusinek, H., Arena, L., Loneragan, C., Lautin, A., Wolkin, A. (2002). Cognitive performance in schizophrenia: Relationship to regional brain volumes and psychiatric symptoms. Psychiatry Research, 116(1–2), 1–23.CrossRefGoogle ScholarPubMed
Selemon, L.D. (2001). Regionally diverse cortical pathology in schizophrenia: Clues to the etiology of the disease. Schizophrenia Bulletin, 27(3), 349–377.CrossRefGoogle Scholar
Selemon, L.D., Rajkowska, G. (2003). Cellular pathology in the dorsolateral prefrontal cortex distinguishes schizophrenia from bipolar disorder. Current Molecular Medicine, 3(5), 427–436.CrossRefGoogle ScholarPubMed
Shifman, S., Bronstein, M., Sternfeld, M., Pisante, A., Weizman, A., Reznik, I., Darvasi, A. (2004). COMT: A common susceptibility gene in bipolar disorder and schizophrenia. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 128B(1), 61–64.CrossRefGoogle Scholar
Simonsen, C., Sundet, K., Vaskinn, A., Birkenaes, A.B., Engh, J.A., Faerden, A., Andreassen, O.A. (2011). Neurocognitive dysfunction in bipolar and schizophrenia spectrum disorders depends on history of psychosis rather than diagnostic group. Schizophrenia Bulletin, 37(1), 73–83.CrossRefGoogle ScholarPubMed
Spitzer, R.L., Williams, J.B., Kroenke, K., Linzer, M., deGruy, F.V. III, Hahn, S.R., Johnson, J.G. (1994). Utility of a new procedure for diagnosing mental disorders in primary care. The PRIME-MD 1000 study. Journal of the American Medical Association, 272(22), 1749–1756.CrossRefGoogle ScholarPubMed
Stuss, D.T., Bisschop, S.M., Alexander, M.P., Levine, B., Katz, D., Izukawa, D. (2001). The Trail Making Test: A study in focal lesion patients. Psychological Assessment, 13(2), 230–239.CrossRefGoogle ScholarPubMed
Stuss, D.T., Floden, D., Alexander, M.P., Levine, B., Katz, D. (2001). Stroop performance in focal lesion patients: Dissociation of processes and frontal lobe lesion location. Neuropsychologia, 39(8), 771–786.CrossRefGoogle ScholarPubMed
Sundet, K., Vaskinn, A. (2008). Estimating premorbid IQ (in Norwegian with English abstract). Journal of the Norwegian Psychological Association, 45, 1108–1115.Google Scholar
Walhovd, K.B., Fjell, A.M., Dale, A.M., Fischl, B., Quinn, B.T., Makris, N., Reinvang, I. (2006). Regional cortical thickness matters in recall after months more than minutes. Neuroimage, 31(3), 1343–1351.CrossRefGoogle ScholarPubMed
Wechsler, D. (2003). Wechsler Adult Intelligence Scale – Third edition (WAIS-III). Norwegian manual. Stockholm: Pearson Assessment.Google Scholar
Wechsler, D. (2007). Wechsler Abbreviated Scale of Intelligence (WASI). Norwegian manual supplement. Stockholm: Pearson Assessment.Google Scholar
White, T., Andreasen, N.C., Nopoulos, P. (2002). Brain volumes and surface morphology in monozygotic twins. Cerebral Cortex, 12(5), 486–493.CrossRefGoogle ScholarPubMed
Williams, H.J., Norton, N., Dwyer, S., Moskvina, V., Nikolov, I., Carroll, L., O'Donovan, M.C. (2010). Fine mapping of ZNF804A and genome-wide significant evidence for its involvement in schizophrenia and bipolar disorder. Molecular Psychiatry, 16, 429–441. doi:mp201036 [pii];10.1038/mp.2010.36CrossRefGoogle ScholarPubMed
Wolf, R.C., Hose, A., Frasch, K., Walter, H., Vasic, N. (2008). Volumetric abnormalities associated with cognitive deficits in patients with schizophrenia. European Psychiatry, 23(8), 541–548.CrossRefGoogle ScholarPubMed
Zimmerman, M.E., Brickman, A.M., Paul, R.H., Grieve, S.M., Tate, D.F., Gunstad, J., Gordon, E. (2006). The relationship between frontal gray matter volume and cognition varies across the healthy adult lifespan. American Journal of Geriatric Psychiatry, 14(10), 823–833.CrossRefGoogle ScholarPubMed
Zimmerman, M.E., DelBello, M.P., Getz, G.E., Shear, P.K., Strakowski, S.M. (2006). Anterior cingulate subregion volumes and executive function in bipolar disorder. Bipolar Disorder, 8(3), 281–288.CrossRefGoogle ScholarPubMed
Zipparo, L., Whitford, T.J., Redoblado Hodge, M.A., Lucas, S., Farrow, T.F., Brennan, J., Harris, A.W. (2008). Investigating the neuropsychological and neuroanatomical changes that occur over the first 2–3 years of illness in patients with first-episode schizophrenia. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 32(2), 531–538.CrossRefGoogle ScholarPubMed
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