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Dexamphetamine boosts naming treatment effects in chronic aphasia

Published online by Cambridge University Press:  18 October 2007

EMMA WHITING ,
HELEN J. CHENERY ,
JONATHAN CHALK  and
DAVID A. COPLAND
EMMA WHITING
Affiliation:
Division of Speech Pathology, School of Health and Rehabilitation Sciences, The University of Queensland, Australia
HELEN J. CHENERY
Affiliation:
Division of Speech Pathology, School of Health and Rehabilitation Sciences, The University of Queensland, Australia
JONATHAN CHALK
Affiliation:
Department of Medicine, School of Medicine and Centre for Magnetic Resonance, The University of Queensland, Australia
DAVID A. COPLAND
Affiliation:
Division of Speech Pathology, School of Health and Rehabilitation Sciences, The University of Queensland, Australia
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Abstract

To date, minimal research has investigated the effect of combining dexamphetamine with standard naming therapy after stroke. The present study used a double-blind, placebo-controlled, multiple baseline, crossover design with two individuals in the chronic stage of stroke recovery. Each individual attended two 4-week blocks of naming therapy (two to three treatment sessions per week). Dexamphetamine (10 mg) was administered at the start of each session during one therapy block, while a placebo was administered during the other therapy block. Therapy progress on treated and untreated items was assessed by a confrontation naming task during and after each therapy block. Both individuals showed greater progress in therapy and maintenance of therapy gains when behavioral treatment was combined with dexamphetamine rather than placebo, although this gain was only statistically significant in one individual. There was no significant improvement on a control task (nonword reading) in either individual. The results provide preliminary evidence that dexamphetamine paired with combined semantic and phonological therapy may be beneficial for the treatment of naming disorders in chronic aphasia. (JINS, 2007, 13, 972–979.)

Keywords

PharmacotherapyAmphetamineStrokeAnomiaNaming therapyAphasia
Type
Research Article
Information
Journal of the International Neuropsychological Society , Volume 13 , Issue 6 , November 2007 , pp. 972 - 979
Copyright
© 2007 The International Neuropsychological Society

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