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Psychosocial function in schizophrenia and bipolar disorder: Relationship to neurocognition and clinical symptoms

Published online by Cambridge University Press:  28 May 2010

CARMEN SIMONSEN ,
KJETIL SUNDET ,
ANJA VASKINN ,
TORILL UELAND ,
KRISTIN LIE ROMM ,
TONE HELLVIN ,
INGRID MELLE ,
SVEIN FRIIS  and
OLE A. ANDREASSEN
CARMEN SIMONSEN*
Affiliation:
Psychosis Research Section, Oslo University Hospital, Oslo, Norway Department of Psychology, University of Oslo, Oslo, Norway
KJETIL SUNDET
Affiliation:
Department of Psychology, University of Oslo, Oslo, Norway
ANJA VASKINN
Affiliation:
Psychosis Research Section, Oslo University Hospital, Oslo, Norway
TORILL UELAND
Affiliation:
Psychosis Research Section, Oslo University Hospital, Oslo, Norway Institute of Clinical Medicine, University of Oslo, Oslo, Norway
KRISTIN LIE ROMM
Affiliation:
Psychosis Research Section, Oslo University Hospital, Oslo, Norway Institute of Clinical Medicine, University of Oslo, Oslo, Norway
TONE HELLVIN
Affiliation:
Psychosis Research Section, Oslo University Hospital, Oslo, Norway Institute of Clinical Medicine, University of Oslo, Oslo, Norway
INGRID MELLE
Affiliation:
Psychosis Research Section, Oslo University Hospital, Oslo, Norway Institute of Clinical Medicine, University of Oslo, Oslo, Norway
SVEIN FRIIS
Affiliation:
Psychosis Research Section, Oslo University Hospital, Oslo, Norway Institute of Clinical Medicine, University of Oslo, Oslo, Norway
OLE A. ANDREASSEN
Affiliation:
Psychosis Research Section, Oslo University Hospital, Oslo, Norway Institute of Clinical Medicine, University of Oslo, Oslo, Norway
*
*Correspondence and reprint requests to: Carmen Simonsen, Psychosis Research Section - TOP, Building 49, Oslo University Hospital, Kirkeveien 166, 0407 Oslo, Norway. E-mail: c.e.simonsen@medisin.uio.no
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Abstract

In line with a dimensional approach to psychopathology, we examined whether psychosocial function and its relationship to neurocognition and clinical symptoms differ across schizophrenia and bipolar disorder subgroups with and without a history of affective or psychotic episodes. From the TOP study, a heterogeneous sample of individuals with schizophrenia spectrum disorders without (n = 60) and with a history of affective episodes (n = 54); individuals with bipolar spectrum disorders with (n = 64) and without a history of psychosis (n = 56) and healthy controls (n = 268) participated. Psychosocial functioning was measured with the Social Functioning Scale (self-rated) and the Global Assessment of Functioning Scale (clinician-rated), neurocognition with a comprehensive neuropsychological test battery, and symptoms with Inventory of Depressive Symptomatology, Young Mania Rating Scale, and Positive and Negative Syndrome Scale. Clinician-rated functioning was poorer in schizophrenia groups than in bipolar groups, but self-rated functioning was similar across all clinical groups and poorer than in controls. Neurocognition and current clinical symptoms were associated with psychosocial function in bivariate analyses, but current symptoms had a greater independent contribution to functioning than neurocognition across clinical groups in multivariate analyses. Despite differences in neurocognition and psychosocial function, groups showed the same pattern in prediction of functioning irrespective of DSM-IV or clinical definition. (JINS, 2010, 16, 771–783.)

Keywords

FunctioningFunctional outcomeCommunity functioningHistory of affective episodesHistory of psychotic episodesNeuropsychological tests
Type
Research Articles
Information
Journal of the International Neuropsychological Society , Volume 16 , Issue 5 , September 2010 , pp. 771 - 783
Copyright
Copyright © The International Neuropsychological Society 2010

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