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Eumelanin-Based Organic Bioelectronics: Myth or Reality?

Published online by Cambridge University Press:  28 December 2015

Mario Barra ,
Irene Bonadies ,
Cosimo Carfagna ,
Antonio Cassinese ,
Francesca Cimino ,
Orlando Crescenzi ,
Valeria Criscuolo ,
d'Ischia Marco ,
Maria Grazia Maglione  and
Paola Manini
...Show all authors
Mario Barra
Affiliation:
CNR-SPIN and Department of Physics, University of Naples Federico II, Piazzale Tecchio 80, Naples 80125, Italy Naples, IT
Irene Bonadies
Affiliation:
Institute for Polymers, Composites and Biomaterials (IPCB), CNR, Via Campi Flegrei 34, 80078 Pozzuoli (Na), Italy Naples, IT
Cosimo Carfagna
Affiliation:
Institute for Polymers, Composites and Biomaterials (IPCB), CNR, Via Campi Flegrei 34, 80078 Pozzuoli (Na), Italy Naples, IT
Antonio Cassinese
Affiliation:
Universita degli Studi di Napoli Federico II, Department of Physics Napoli, Campania, IT
Francesca Cimino
Affiliation:
Institute for Polymers, Composites and Biomaterials (IPCB), CNR, Via Campi Flegrei 34, 80078 Pozzuoli (Na), Italy Naples, IT
Orlando Crescenzi
Affiliation:
Universita degli Studi di Napoli Federico II Napoli, Campania, Department of Chemical Sciences.
Valeria Criscuolo
Affiliation:
Universita degli Studi di Napoli Federico II Napoli, Campania, Department of Chemical Sciences.
d'Ischia Marco
Affiliation:
Universita degli Studi di Napoli Federico II Napoli, Campania, Department of Chemical Sciences.
Maria Grazia Maglione
Affiliation:
ENEA Agenzia Nazionale per Le Nuove Tecnologie l\'Energia e lo Sviluppo Economico Sostenibile, C.R.Portici, UTTP, Piazzale E.Fermi 1, Portici, NA, Italy
Paola Manini
Affiliation:
Universita degli Studi di Napoli Federico II Napoli, Campania, Department of Chemical Sciences.
Ludovico Migliaccio
Affiliation:
ENEA Agenzia Nazionale per Le Nuove Tecnologie l\'Energia e lo Sviluppo Economico Sostenibile, C.R.Portici, UTTP, Piazzale E.Fermi 1, Portici, NA, Italy
Anna Musto
Affiliation:
Universita degli Studi di Napoli Federico II, Department of Molecular medicine and Medical Biotechnology Napoli, Campania, IT Ceinge Biotecnologie Avanzate Via Gaetano Salvatore 486, 80145 Naples, Italy Naples, IT
Alessandra Napolitano
Affiliation:
Universita degli Studi di Napoli Federico II Napoli, Campania, Department of Chemical Sciences.
Angelica Navarra
Affiliation:
Universita degli Studi di Napoli Federico II, Department of Molecular medicine and Medical Biotechnology Napoli, Campania, IT Ceinge Biotecnologie Avanzate Via Gaetano Salvatore 486, 80145 Naples, Italy Naples, IT
Lucia Panzella
Affiliation:
Universita degli Studi di Napoli Federico II Napoli, Campania, Department of Chemical Sciences.
Silvia Parisi
Affiliation:
Universita degli Studi di Napoli Federico II, Department of Molecular medicine and Medical Biotechnology Napoli, Campania, IT Ceinge Biotecnologie Avanzate Via Gaetano Salvatore 486, 80145 Naples, Italy Naples, IT
Alessandro Pezzella*
Affiliation:
Institute for Polymers, Composites and Biomaterials (IPCB), CNR, Via Campi Flegrei 34, 80078 Pozzuoli (Na), Italy Naples, IT Universita degli Studi di Napoli Federico II Napoli, Campania, Department of Chemical Sciences.
Carmela Tania Prontera
Affiliation:
ENEA Agenzia Nazionale per Le Nuove Tecnologie l\'Energia e lo Sviluppo Economico Sostenibile, C.R.Portici, UTTP, Piazzale E.Fermi 1, Portici, NA, Italy
Paolo Tassini
Affiliation:
ENEA Agenzia Nazionale per Le Nuove Tecnologie l\'Energia e lo Sviluppo Economico Sostenibile, C.R.Portici, UTTP, Piazzale E.Fermi 1, Portici, NA, Italy
*
*(Email: alessandro.pezzella@unina.it)
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Abstract

Eumelanins, the black insoluble pigments of human skin, eyes and substantia nigra (neuromelanin), stand today as a unique source of inspiration for the design and implementation of soft biocompatible multifunctional materials for bio-optoelectronic devices. Interest in eumelanins stems from bioavailability, biocompatibility and a peculiar set of physicochemical properties, i.e. broadband absorption in the UV-visible range, intrinsic free radical character, water-dependent hybrid ionic–electronic conductor behaviour, supporting optimistic feelings about a possible rise of eumelanin-mimics as innovative bioinspired solutions for organic bioelectronics.

However, a number of conceptual and technological gaps still hinder a rapid progress of melanin-based organic electronics and bioelectronics, including in particular the limited contribution of electronic conductivity and current decay with time under biasing. Herein, we provide a concise overview of the structural and optoelectronic properties of melanins with a view to bringing to focus main issues and challenges en route to bioelectronic applications.

Keywords

biomaterialoptoelectroniccoating
Type
Articles
Information
MRS Advances , Volume 1 , Issue 57: Biomaterials and Soft Materials , 2016 , pp. 3801 - 3810
Copyright
Copyright © Materials Research Society 2015 

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References

REFERENCES

d'Ischia, M.; Napolitano, A.; Pezzella, A.; Meredith, P.; Sarna, T. Angew Chem Int Edit 2009, 48, 3914–3921.CrossRefGoogle Scholar
d'Ischia, M.; Wakamatsu, K.; Cicoira, F.; Di Mauro, E.; Garcia-Borron, J. C.; Commo, S.; Galvan, I.; Ghanem, G.; Kenzo, K.; Meredith, P.; Pezzella, A.; Santato, C.; Sarna, T.; Simon, J. D.; Zecca, L.; Zucca, F. A.; Napolitano, A.; Ito, S. Pigment Cell Melanoma Res 2015, 28, 520–544.CrossRefGoogle Scholar
Bothma, J. P.; De Boor, J.; Divakar, U.; Schwenn, P. E.; Meredith, P. Advanced Materials 2008, 20, 3539–3542.CrossRefGoogle Scholar
Bettinger, C. J.; Bruggeman, P. P.; Misra, A.; Borenstein, J. T.; Langer, R. Biomaterials 2009, 30, 3050–3057.CrossRefGoogle Scholar
Bloisi, F.; Pezzella, A.; Barra, M.; Chiarella, F.; Cassinese, A.; Vicari, L. Journal of Applied Physics 2011, 110.CrossRefGoogle Scholar
Pezzella, A.; Barra, M.; Musto, A.; Navarra, A.; Alfe, M.; Manini, P.; Parisi, S.; Cassinese, A.; Criscuolo, V.; d'Ischia, M. Materials Horizons 2015, 2, 212–220.CrossRefGoogle Scholar
Ambrico, M.; Ambrico, P. F.; Ligonzo, T.; Cardone, A.; Cicco, S. R.; D'Ischia, M.; Farinola, G. M. Journal of Materials Chemistry C 2015, 3, 6413–6423.CrossRefGoogle Scholar
Bonadies, I.; Cimino, F.; Carfagna, C.; Pezzella, A. Biomacromolecules 2015, 16, 1667–1670.CrossRefGoogle Scholar
Manini, P.; Criscuolo, V.; Ricciotti, L.; Pezzella, A.; Barra, M.; Cassinese, A.; Crescenzi, O.; Maglione, M. G.; Tassini, P.; Minarini, C.; Barone, V.; D'Ischia, M. ChemPlusChem 2015, 80, 919–927.CrossRefGoogle Scholar
Gargiulo, V.; Alfè, M.; Capua, R. D.; Togna, A. R.; Cammisotto, V.; Fiorito, S.; Musto, A.; Navarra, A.; Parisi, S.; Pezzella, A. Journal of Materials Chemistry B 2015, 3, 5070–5079.CrossRefGoogle Scholar
Pinna, A.; Simbula, F.; Marongiu, D.; Pezzella, A.; d'Ischia, M.; Mula, G. Rsc Advances 2015, 5, 56704–56710.CrossRefGoogle Scholar
Cicco, S. R.; Ambrico, M.; Ambrico, P. F.; Talamo, M. M.; Cardone, A.; Ligonzo, T.; Di Mundo, R.; Giannini, C.; Sibillano, T.; Farinola, G. M.; Manini, P.; Napolitano, A.; Criscuolo, V.; D'Ischia, M. J Mater Chem C 2015, 3, 2810–2816.CrossRefGoogle Scholar
D'Ischia, M.; Wakamatsu, K.; Napolitano, A.; Briganti, S.; Garcia-Borron, J. C.; Kovacs, D.; Meredith, P.; Pezzella, A.; Picardo, M.; Sarna, T.; Simon, J. D.; Ito, S. Pigment Cell and Melanoma Research 2013, 26, 616–633.CrossRefGoogle Scholar
d'Ischia, M.; Wakamatsu, K.; Napolitano, A.; Briganti, S.; Garcia-Borron, J. C.; Kovacs, D.; Meredith, P.; Pezzella, A.; Picardo, M.; Sarna, T.; Simon, J. D.; Ito, S. Pigment Cell Melanoma Res 2013, 26, 616–633.CrossRefGoogle Scholar
Corani, A.; Huijser, A.; Iadonisi, A.; Pezzella, A.; Sundström, V.; Dschia, M. Journal of Physical Chemistry B 2012, 116, 13151–13158.CrossRefGoogle Scholar
Ito, S.; Wakamatsu, K.; d'ischia, M.; Napolitano, A.; Pezzella, A. In Melanins and Melanosomes: Biosynthesis, Biogenesis, Physiological, and Pathological Functions 2011, p 167–185.CrossRefGoogle Scholar
Brenner, M.; Hearing, V. J. Photochemistry and Photobiology 2008, 84, 539–549.CrossRefGoogle Scholar
Chedekel, M. R. Photochemistry and Photobiology 1982, 35, 881–885.CrossRefGoogle ScholarPubMed
Corani, A.; Huijser, A.; Gustavsson, T.; Markovitsi, D.; Malmqvist, P. A.; Pezzella, A.; D'Ischia, M.; Sundström, V. Journal of the American Chemical Society 2014, 136, 11626–11635.CrossRefGoogle Scholar
Bridelli, M. G.; Ciati, A.; Crippa, P. R. Biophysical Chemistry 2006, 119, 137–145.CrossRefGoogle Scholar
Buszman, E.; Rózańska, R. Pharmazie 2003, 58, 507–511.Google Scholar
Borovanskỳ, J.; Riley, P. A. In Melanins and Melanosomes: Biosynthesis, Biogenesis, Physiological, and Pathological Functions 2011, p 343–381.CrossRefGoogle Scholar
McGinness, J.; Proctor, P. Journal of theoretical biology 1973, 39, 677–678.CrossRefGoogle Scholar
Huijser, A.; Pezzella, A.; Sundstrom, V. Physical chemistry chemical physics : PCCP 2011, 13, 9119–9127.CrossRefGoogle Scholar
McGinness, J.; Corry, P.; Proctor, P. Science 1974, 183, 853–855.CrossRefGoogle Scholar
Mostert, A. B.; Powell, B. J.; Pratt, F. L.; Hanson, G. R.; Sarna, T.; Gentle, I. R.; Meredith, P. Proc Natl Acad Sci U S A 2012, 109, 8943–8947.CrossRefGoogle Scholar
Rienecker, S. B.; Mostert, A. B.; Schenk, G.; Hanson, G. R.; Meredith, P. The journal of physical chemistry. B 2015, 119, 14994–15000.CrossRefGoogle Scholar
García-Frutos, E. M.; Pandey, U. K.; Termine, R.; Omenat, A.; Barberá, J.; Serrano, J. L.; Golemme, A.; Gõmez-Lor, B. Angewandte Chemie - International Edition 2011, 50, 7399–7402.CrossRefGoogle Scholar
Valentine, R. A.; Whyte, A.; Awaga, K.; Robertson, N. Tetrahedron Letters 2012, 53, 657–660.CrossRefGoogle Scholar
Gómez-Lor, B.; Hennrich, G.; Alonso, B.; Monge, A.; Gutierrez-Puebla, E.; Echavarren, A. M. Angewandte Chemie - International Edition 2006, 45, 4491–4494.CrossRefGoogle Scholar
Ji, L.; Fang, Q.; Yuan, M. S.; Liu, Z. Q.; Shen, Y. X.; Chen, H. F. Organic Letters 2010, 12, 5192–5195.CrossRefGoogle Scholar
Gargiulo, V.; Alfe, M.; Di Capua, R.; Togna, A. R.; Cammisotto, V.; Fiorito, S.; Musto, A.; Navarra, A.; Parisi, S.; Pezzella, A. Journal of Materials Chemistry B 2015, 3, 5070–5079.CrossRefGoogle Scholar
D'Ischia, M.; Napolitano, A.; Ball, V.; Chen, C. T.; Buehler, M. J. Accounts of Chemical Research 2014, 47, 3541–3550.CrossRefGoogle Scholar