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Hydroxyapatite Nanocrystal Deposited Titanium Dioxide Nanotubes Loaded with Antibiotics for Combining Biocompatibility and Antibacterial Properties

Published online by Cambridge University Press:  28 January 2018

Xuefei Zhang ,
Yuan Zhang  and
Matthew Z. Yates
Xuefei Zhang*
Affiliation:
Materials Science Program, University of Rochester, Rochester, NY14627, USA
Yuan Zhang
Affiliation:
Department of Chemical Engineering, University of Rochester, Rochester, NY14627, USA
Matthew Z. Yates
Affiliation:
Department of Chemical Engineering, University of Rochester, Rochester, NY14627, USA
*
*(Email: Zxfdw35@gmail.com)
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Abstract

Hydroxyapatite (HA)/nanotubular titanium dioxide (TiO2) composite coatings loaded with antibiotics were developed to combine biocompatibility and antibacterial property. TiO2 nanotubes were first fabricated on Ti plates using anodization techniques. Then HA nanocrystals were synthesized on the TiO2 nanotubes by electrochemical deposition, followed by loading of a model drug compound, streptomycin. The streptomycin release profile of the composite coating was investigated. Bacterial tests demonstrate that the streptomycin-loaded composite coatings were highly effective in inhibiting bacterial growth. Simulated body fluid (SBF) experiments indicated that the composite coatings possessed good osseointegration capability.

Keywords

biomaterialcoatingelectrochemical synthesis
Type
Articles
Information
MRS Advances , Volume 3 , Issue 30: Biomaterials and Soft Materials , 2018 , pp. 1703 - 1709
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Copyright
Copyright © Materials Research Society 2018 

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References

REFERENCES

Saini, M., Singh, Y., Arora, P., Arora, V., and Jain, K., World J. Clin. Cases WJCC 3, 52 (2015).CrossRefGoogle Scholar
Parcharoen, Y., Kajitvichyanukul, P., Sirivisoot, S., and Termsuksawad, P., Appl. Surf. Sci. 311, 54 (2014).CrossRefGoogle Scholar
Zakharov, N.A., Polunina, I.A., Polunin, K.E., Rakitina, N.M., Kochetkova, E.I., Sokolova, N.P., and Kalinnikov, V.T., Inorg. Mater. 40, 641 (2004).CrossRefGoogle Scholar
Zhang, X., Chaimayo, W., Yang, C., Yao, J., Miller, B.L., and Yates, M.Z., Surf. Coat. Technol. 325, 39 (2017).CrossRefGoogle Scholar
Hetrick, E.M. and Schoenfisch, M.H., Chem. Soc. Rev. 35, 780 (2006).CrossRefGoogle Scholar
Xiao, X., Yu, J., Tang, H., Mao, D., Wang, C., and Liu, R., Mater. Chem. Phys. 138, 695 (2013).CrossRefGoogle Scholar
Owens, C. D. and Stoessel, K., Journal of Hospital Infection, vol. 70, pp. 3–10, Nov. 2008.CrossRefGoogle Scholar
Negi, V., Pal, S., Juyal, D., Sharma, M. K., and Sharma, N., J Clin Diagn Res, vol. 9, no. 10, pp. DC17–DC20, Oct. 2015.Google Scholar
Fang, D., Luo, Z., Huang, K., and Lagoudas, D.C., Appl. Surf. Sci. 257, 6451 (2011).CrossRefGoogle Scholar
Oh, S.-H., Finõnes, R.R., Daraio, C., Chen, L.-H., and Jin, S., Biomaterials 26, 4938 (2005).CrossRefGoogle Scholar
Fu, C., Zhang, X., Savino, K., Gabrys, P., Gao, Y., Chaimayo, W., Miller, B.L., and Yates, M.Z., Surf. Coat. Technol. 301, 13 (2016).CrossRefGoogle Scholar
Kokubo, T. and Takadama, H., in Handb. Biominer., edited by Bäuerlein, E. (Wiley-VCH Verlag GmbH, 2007), pp. 97–109.CrossRefGoogle Scholar