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Piezo- and Magnetoelectric Polymers as Biomaterials for Novel Tissue Engineering Strategies

Published online by Cambridge University Press:  20 February 2018

C. Ribeiro
Affiliation:
Centro de Física, Universidade do Minho, Campus de Gualtar, 4710-058Braga, Portugal CEB - Centre of Biological Engineering, University of Minho, Campus de Gualtar, 4710-057Braga, Portugal
D.M. Correia
Affiliation:
Department of chemistry and CQ-VR, University of Trás-os-Montes e Alto Douro, 5000-801Vila Real, Portugal BCMaterials, Parque Científico y Tecnológico de Bizkaia, 48160Derio, Spain
S. Ribeiro
Affiliation:
Centro de Física, Universidade do Minho, Campus de Gualtar, 4710-058Braga, Portugal Centre of Molecular and Environmental Biology (CBMA), Universidade do Minho, Campus de Gualtar, 4710-057Braga, Portugal
M. M. Fernandes
Affiliation:
Centro de Física, Universidade do Minho, Campus de Gualtar, 4710-058Braga, Portugal CEB - Centre of Biological Engineering, University of Minho, Campus de Gualtar, 4710-057Braga, Portugal
S. Lanceros-Mendez*
Affiliation:
BCMaterials, Parque Científico y Tecnológico de Bizkaia, 48160Derio, Spain IKERBASQUE, Basque Foundation for Science, 48013Bilbao, Spain
*
*corresponding author: senentxu.lanceros@bcmaterials.net
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Abstract

Tissue engineering and regenerative medicine are increasingly taking advantage of active materials, allowing to provide specific clues to the cells. In particular, the use of electroactive polymers that deliver an electrical signal to the cells upon mechanical solicitation, open new scientific and technological opportunities, as they in fact mimic signals and effects that occur in living tissues, allowing the development of suitable microenvironments for tissue regeneration. Thus, a novel overall strategy for bone and muscle tissue engineering was developed based on the fact that these cells type are subjected to mechano-electrical stimuli in their in vivo microenvironment and that piezo- and magnetoelectric polymers, used as scaffolds, are suitable for delivering those cues. The processing and functional characterizations of piezoelectric and magnetoelectric polymers based on poly(vinylindene fluoride) and poly-L-lactic acid in a variety of shapes, from microspheres to electrospun mats and three dimensional scaffolds, are shown as well as their performance in the development of novel bone and muscle tissue engineering.

Type
Articles
Copyright
Copyright © Materials Research Society 2018 

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References

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