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Chemoenzymatic Preparation of Sugar-Based Hydrogels

Published online by Cambridge University Press:  15 February 2011

D. G. Rethwisch ,
X. Chen ,
B. D. Martin  and
J. S. Dordick
D. G. Rethwisch
Affiliation:
Department of Chemical and Biochemical Engineering, University of Iowa, Iowa City, IA 52242
X. Chen
Affiliation:
Department of Chemical and Biochemical Engineering, University of Iowa, Iowa City, IA 52242
B. D. Martin
Affiliation:
Department of Chemical and Biochemical Engineering, University of Iowa, Iowa City, IA 52242
J. S. Dordick
Affiliation:
Department of Chemical and Biochemical Engineering, University of Iowa, Iowa City, IA 52242
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Abstract

We have prepared sugar-based hydrogels using a chemoenzymatic synthetic approach. Specifically, the regioselectivity of enzymes was used to prepare sugar acrylate monomers. These monomers were polymerized with a crosslinker in a standard free radical polymerization. The polymers consist of a polyacrylate backbone with sucrose, (α-methyl glucoside, or β-methyl galactoside pendant groups. These materials are highly water absorbent swelling to more than 100 times their initial weight when placed in water. The degree of swelling for poly(β-methyl galactoside 6-acrylate) hydrogel was relatively insensitive to pH (from pH 4.5-9) and ionic strength (0.15-3 M NaCl). Potential applications of these materials include waterabsorbents and drug delivery systems.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 330: Symposium S – Biomolecular Materials by Design , 1993 , 225
Copyright
Copyright © Materials Research Society 1994

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References

REFERENCES

1. Canal, T., Peppas, N. A., J. Biomed. Mater. Res. 23, 1183 (1989).CrossRefGoogle Scholar
2. Rodriguez, F., Principles of Polymer Systems, 3rd Ed, Hemisphere: New York, 1989.Google Scholar
3. Otake, T., Bull. Chem. Soc. Jpn. 43, 3199 (1972).CrossRefGoogle Scholar
4. Ballard, J. M., Hough, L., Richardson, A. C., Carbohydr. Res. 83, 138, (1980).CrossRefGoogle Scholar
5. Hough, L., Phadnis, S. D., Tarelli, E., Carbohydr. Res. 44, 37 (1975).CrossRefGoogle Scholar
6. Klein, J. D., Herzog, D., Hajibegli, A., Makromol. Chem. Rapid. Comm. 6, 675 (1985).CrossRefGoogle Scholar
7. Patil, D. R., Dordick, J. S., Rethwisch, D. G., Macromolecules 24, 3462 (1991).CrossRefGoogle Scholar
8. Martin, B. D., Ampofo, S., Linhardt, R. J., Dordick, J. S., Macromolecules 25, 7081 (1992)CrossRefGoogle Scholar
9. Patil, D. R., Rethwisch, D. G., Dordick, J. S., Biotechnol. Bioeng. 37, 639 (1991).CrossRefGoogle Scholar
10. Dordick, J. S., Enzyme Microb. Technol. 11, 194 (1989).CrossRefGoogle Scholar
11. Dabulis, K., Klibanov, A.M., Biotechnol. Bioeng. 41, 566 (1993).CrossRefGoogle Scholar
12. Kazanskii, K. S., Dubrovskii, S. A., Adv. Polym. Sci. 104, 99 (1992).Google Scholar