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Chemoenzymatic Preparation of Sugar-Based Hydrogels

Published online by Cambridge University Press:  15 February 2011

D. G. Rethwisch ,
X. Chen ,
B. D. Martin  and
J. S. Dordick
D. G. Rethwisch
Affiliation:
Department of Chemical and Biochemical Engineering, University of Iowa, Iowa City, IA 52242
X. Chen
Affiliation:
Department of Chemical and Biochemical Engineering, University of Iowa, Iowa City, IA 52242
B. D. Martin
Affiliation:
Department of Chemical and Biochemical Engineering, University of Iowa, Iowa City, IA 52242
J. S. Dordick
Affiliation:
Department of Chemical and Biochemical Engineering, University of Iowa, Iowa City, IA 52242
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Abstract

We have prepared sugar-based hydrogels using a chemoenzymatic synthetic approach. Specifically, the regioselectivity of enzymes was used to prepare sugar acrylate monomers. These monomers were polymerized with a crosslinker in a standard free radical polymerization. The polymers consist of a polyacrylate backbone with sucrose, (α-methyl glucoside, or β-methyl galactoside pendant groups. These materials are highly water absorbent swelling to more than 100 times their initial weight when placed in water. The degree of swelling for poly(β-methyl galactoside 6-acrylate) hydrogel was relatively insensitive to pH (from pH 4.5-9) and ionic strength (0.15-3 M NaCl). Potential applications of these materials include waterabsorbents and drug delivery systems.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 330: Symposium S – Biomolecular Materials by Design , 1993 , 225
Copyright
Copyright © Materials Research Society 1994

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References

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