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Collagenous Materials Enhance Healing of Chronic Skin Ulcers

Published online by Cambridge University Press:  26 February 2011

Frederick H. Silver ,
Charles J. Doillon ,
Blas Rojo ,
Robert M. Olson ,
Chandrakala Y. Kamath  and
Richard A. Berg
Frederick H. Silver
Affiliation:
Biomaterials Center, Department of Pathology and Graduate Program in Biomedical Engineering, UMDNJ-Robert Wood Johnson Medical Center, 675 Hoes Lane, Piscataway, New Jersey 08854
Charles J. Doillon
Affiliation:
Biomaterials Center, Department of Pathology and Graduate Program in Biomedical Engineering, UMDNJ-Robert Wood Johnson Medical Center, 675 Hoes Lane, Piscataway, New Jersey 08854
Blas Rojo
Affiliation:
Biomaterials Center, Department of Pathology and Graduate Program in Biomedical Engineering, UMDNJ-Robert Wood Johnson Medical Center, 675 Hoes Lane, Piscataway, New Jersey 08854
Robert M. Olson
Affiliation:
Department of Surgery, UMDNJ-Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, New Jersey 08854
Chandrakala Y. Kamath
Affiliation:
Department of Surgery, UMDNJ-Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, New Jersey 08854
Richard A. Berg
Affiliation:
Department of Biochemistry, UMDNJ-Robert Wood Johnson Medica School, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, Piscataway, New Jersey 08854
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Abstract

Type I collagen in a porous sponge form attracts fibroblasts in culture and accelerates repair of animal wounds. This study examines the effect of type I collagen sponge and flakes on healing of chronic skin ulcers. Patients included in this study had skin ulcers.

Patients included in this study had skin ulcers characterized by loss of dermis and epidermis without exposure of muscle, tendon or bone. Patients showing evidence of systemic infection or patients with ulcers that decreased in area during an initial three week observation period were excluded.

Three out of seven patients treated with a collagen sponge and twelve out of fourteen patients treated with collagen flakes showed a 40% decrease in wound area after six weeks of treatment. In comparison, eighteen control patients showed no change in wound area over the same time interval. These results suggest that collagen flakes are effective in initiating healing of chronic skin ulcers.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 110: Symposium M – Biomedical Materials and Devices , 1987 , 371
Copyright
Copyright © Materials Research Society 1988

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References

1. Constantia, M.B. (Editor), Pressure Ulcers. Principles and Techniques of Management, (Little Brown and Company, Boston, 1980).Google Scholar
2. Yerbov, J. (Editor), Skin Diseases In The Elderly, (Lippincott Co., Philadelphia, 1974) pp 8–22.Google Scholar
3. Kleinman, K.K., Klebe, R.J., and Martin, G.R., J. Cell Biol. 88, 473 (1981).Google Scholar
4. Dunn, G.A., and Ebendal, T., Exp. Cell Res. 111, 475 (1978).Google Scholar
5. Grinnell, F., Bennett, M.H., Meth. in Enzymology 82, 535 (1982).Google Scholar
6. Thomaseck, J.T., Hay, E.D. and Fujiware, K., Dev. Biol. 92, 107 (1982).Google Scholar
7. Doillon, C.J., Whyne, C.F., Berg, R.A., Olson, R.M., and Silver, F.H., Scanning Electron Microscopy, 1984/III, 1313.Google Scholar
8. Doillon, C.J., and Silver, F.H., Biomaterials 7, 3 (1986).Google Scholar
9. Yannas, I.V., Burke, J.F., Orgill, D.P., and Skrabut, E.M., Science 215, 174 (1982).Google Scholar
10. Bell, E., Sher, S., Hull, B., Merrill, C., Rosen, S., Chamson, A., Asselineau, D., Dubertret, D., Coulomb, B., Lapiere, C., Nusgens, B., Neveux, Y., J. Invest. Dermatol. 81, 25 (1983).Google Scholar
11. Weadock, K.S., Olson, R.M., and Silver, F.H., Biomat. Med. Devices Artif. Organs 11, 293 (1984).Google Scholar
12. Doillon, C.J., Whyne, C.F., Brandwein, S., and Silver, F.H., J. Biomedical Materials Research 20, 1219 (1986).Google Scholar