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Compositionally Modified Hydroxyapatite Nanocrystals for Polymer/Ceramic Scaffold Applications

Published online by Cambridge University Press:  26 February 2011

Andrei Stanishevsky ,
Peserai Chinoda ,
Shafiul Chowdhury ,
Vinoy Thomas ,
Aaron Catledge  and
Derrick Dean
Andrei Stanishevsky
Affiliation:
astan@uab.edu, University of Alabama at Birmingham, 1300 University Blvd., CH310, Birmingham, Alabama, 35294-1170, United States
Peserai Chinoda
Affiliation:
pchinoda@uab.edu
Shafiul Chowdhury
Affiliation:
shafiul@uab.edu
Vinoy Thomas
Affiliation:
vthomas@uab.edu
Aaron Catledge
Affiliation:
catledge@uab.edu
Derrick Dean
Affiliation:
deand@uab.edu
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Abstract

The polymer/bioceramic composite materials attract much attention for the development of bioresorbable implants and tissue engineering scaffolds. Hydroxyapatite (HA) is the most commonly used bioceramic material due to its similarity to the major mineral component of the hard tissue. We synthesized carbonated and Mg-substituted HA nanocrystals with various concentrations of CO32− and Mg2+ ions by chemical precipitation in the range of the process temperatures from 25 °C to 100 °C.

The HA nanocrystals were mixed with several polymeric materials (PCL, PLA, PVA, collagen) to fabricate bulk and nanofiber polymer/HA nanoparticle composites with the HA loading up to 80 % by weight. The HA nanocrystals and polymer/HA composites were characterized by X-ray diffraction, FT-IR spectroscopy, scanning electron and atomic force microscopy. Mechanical properties of the composites were investigated using nanoindentation technique.

Keywords

polymerceramicnanoscale
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 897: Symposium J – Biomemetic Polymers and Gels , 2005 , 0897-J03-18
Copyright
Copyright © Materials Research Society 2006

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