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Dendrimer Nanocomposites as Multifunctional X-ray Contrast Agents

Published online by Cambridge University Press:  01 February 2011

Teyeb Ould Ely ,
Manju Sharma ,
Wojciech Lesniak ,
Donald L. Klippenstein ,
Barbara A. Foster  and
Lajos P. Balogh
Teyeb Ould Ely
Affiliation:
mohamedteyib.ouldely@roswellpark.org, RoswellPark Cancer Institute, Radiation Medicine, Elm and Carlton Streets, Buffalo, NY, 14263, United States, 716-845-8179, 716-845-8254
Manju Sharma
Affiliation:
sharm093@umn.edu, RoswellPark Cancer Institute, Radiation Medicine, Elm and Carlton Streets,, Buffalo, NY, 14263, United States
Wojciech Lesniak
Affiliation:
Wojciech.Lesniak@RoswellPark.org, RoswellPark Cancer Institute, Radiation Medicine, Elm and Carlton Streets, Buffalo, NY, 14263, United States
Donald L. Klippenstein
Affiliation:
Donald.Klippenstein@RoswellPark.org, RoswellPark Cancer Institute, Radiology, Elm and Carlton Streets, Buffalo, NY, 14263, United States
Barbara A. Foster
Affiliation:
Barbara.Foster@RoswellPark.org, RoswellPark Cancer Institute, Pharmacology & Therapeutics, Elm and Carlton Streets, Buffalo, NY, 14263, United States
Lajos P. Balogh
Affiliation:
Lajos.Balogh@RoswellPark.org, RoswellPark Cancer Institute, Radiation Medicine, Elm and Carlton Streets, Buffalo, NY, 14263, United States
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Abstract

We synthesized dendrimer composite nanoparticles and investigated their potential for traditional X-ray imaging and Computed Tomography (CT). These new X-ray contrast agents show better contrast compared to traditional iodine-based contrast agents, and are expected to clear from the blood much slower than commercial agents, permitting longer imaging times. We have also investigated their safety profile in terms of viscosity and osmotic pressure.

Keywords

biomedicalnanostructurecomposite
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1064: Symposium PP – Quantum-Dot and Nanoparticle Bioconjugates–Tools for Sensing and Biomedical Imaging , 2007 , 1064-PP06-18
Copyright
Copyright © Materials Research Society 2008

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References

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