Hostname: page-component-78c5997874-94fs2 Total loading time: 0 Render date: 2024-11-08T08:48:55.277Z Has data issue: false hasContentIssue false
  • English
  • Français

Development of new sol-gel derived Ag-doped biomaterials for dental applications

Published online by Cambridge University Press:  19 April 2012

Xanthippi Chatzistavrou ,
Eleana Kontonasaki ,
Athina Bakopoulou ,
Anna Theocharidou ,
Afroditi Sivropoulou ,
Konstantinos M. Paraskevopoulos ,
Petros Koidis ,
Aldo R. Boccaccini  and
Toshihiro Kasuga
Xanthippi Chatzistavrou
Affiliation:
Department of Frontier Materials, Nagoya Institute of Technology, Showa-ku, Nagoya 466-8555, Japan
Eleana Kontonasaki
Affiliation:
School of Dentistry, Aristotle University of Thessaloniki, Thessaloniki 54124, Greece
Athina Bakopoulou
Affiliation:
School of Dentistry, Aristotle University of Thessaloniki, Thessaloniki 54124, Greece
Anna Theocharidou
Affiliation:
School of Dentistry, Aristotle University of Thessaloniki, Thessaloniki 54124, Greece
Afroditi Sivropoulou
Affiliation:
Biology Department, Aristotle University of Thessaloniki, Thessaloniki 54124, Greece.
Konstantinos M. Paraskevopoulos
Affiliation:
Department of Physics Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece
Petros Koidis
Affiliation:
School of Dentistry, Aristotle University of Thessaloniki, Thessaloniki 54124, Greece
Aldo R. Boccaccini
Affiliation:
Institute of Biomaterials, Department of Materials Science and Engineering, University of Erlangen-Nuremberg, Cauerstrasse 6, 91058 Erlangen, Germany
Toshihiro Kasuga
Affiliation:
Department of Frontier Materials, Nagoya Institute of Technology, Showa-ku, Nagoya 466-8555, Japan
Get access

Abstract

The aim of this work was to develop a new Ag-doped bioactive material with antibacterial behavior, optimizing the properties of the new fabricated composite material in the system SiO2 58.6 -P2O5 7.2 -Al2O3 4.2 -CaO 24.9 -Na2O 2.1 -K2O 3 (wt%). Two systems with different concentrations in Ag2O (Ba with 2.1 and Bb with 4.2 wt%) were prepared by the sol-gel method and compared to the respective silver-free control composite (CONTROL). The microstructural characteristics of the developed compositions were characterized by different techniques as UV/VIS spectroscopy, X-ray diffraction analysis (XRD) and Scanning Electron Microscopy with Energy Dispersive Spectroscopy (SEM-EDS). The antibacterial properties of the Ag-doped glass-ceramics were tested against the bacterial colony Staphylococcus aureus (S. aureus) which is very characteristic oral bacteria and the material-cell interaction was monitored in a primary culture of Human Gingival Fibroblasts (HGFs). Our study shows the successful incorporation of the silver ions in the ceramic structure and the preparation of new Ag-doped composite materials with cell-proliferation-inductive, as well as antibacterial properties indicating their potential application dental tissue restoration strategies.

Keywords

Agcompositebiomaterial
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1417: Symposium KK – Biomaterials for Tissue Regeneration , 2012 , mrsf11-1417-kk06-09
Copyright
Copyright © Materials Research Society 2012

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

1. Kawashita, M., Tsuneyama, S., Miyaji, F., Kokubo, T. et al. . Biomaterials 21, 393 (2000).Google Scholar
2. Chatzistavrou, X., Esteve, D., Hatzistavrou, E., Kontonasaki, E. et al. . Mater. Sci. Eng. C 30, 730 (2010).Google Scholar
3. Saravanapava, P., Gough, J.E., Jones, J.R., Hench, L.L., Key Eng. Mater. 254-256, 1087 (2004).Google Scholar
4. Hillmann, G., Steinkamp-Zucht, A., Geurtsen, W., Gross, G. et al. . Biomaterials 23, 1461 (2002).Google Scholar