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Dual Detection Platform with Refractive Index and SERS SensingBased on Colloidal Gold Functionalized Porous SiliconSubstrates

Published online by Cambridge University Press:  01 February 2011

Yang Jiao ,
Dmitry S. Koktysh  and
Sharon M. Weiss
Yang Jiao
Affiliation:
Department of Electrical Engineering and Computer Science, Vanderbilt University, Nashville, TN 37235, U.S.A.
Dmitry S. Koktysh
Affiliation:
Department of Chemistry, Vanderbilt University, Nashville, TN 37235, U.S.A. Vanderbilt Institute of Nanoscale Science and Engineering, Vanderbilt University, Nashville, TN 37235, U.S.A.
Sharon M. Weiss*
Affiliation:
Department of Electrical Engineering and Computer Science, Vanderbilt University, Nashville, TN 37235, U.S.A. Vanderbilt Institute of Nanoscale Science and Engineering, Vanderbilt University, Nashville, TN 37235, U.S.A.
*
a)Electronic mail: sharon.weiss@vanderbilt.edu
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Abstract

We demonstrate a dual-mode sensing platform based on porous silicon (PSi)substrates coated with colloidal gold (Au) nanoparticles (NPs). This Au-PSicomposite structure supports both molecular fingerprinting via surfaceenhanced Raman scattering (SERS) and quantification of molecular binding viareflectance measurements. Reflectance shifts of 7-10 nm in the infraredregion were observed in the case of adsorbing benzenethiol or antioxidantglutathione molecules on the surface of Au NPs. Subsequent SERS measurementsshowed unique identification for both molecules and provided a < 1 μM and< 1 mM detection resolution for benzenethiol and glutathione,respectively.

Keywords

sensorRaman spectroscopynanoscale

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References

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