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Micro-Topography Enhances Directional Myogenic Differentiation of Skeletal Precursor Cells

Published online by Cambridge University Press:  01 February 2011

Yi Zhao
Yi Zhao*
Affiliation:
zhao.178@osu.edu, The Ohio State University, Department of Biomedical Engineering, 294 Bevis Hall, 1080 Carmack Road, Columbus, OH, 43210, United States, (614) 247-7424, (614) 292-7301
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Abstract

Skeletal muscle tissues were constructed using an in vitro model, by differentiating skeletal myoblasts using an array of linear microstructures with the medium aspect ratios. The adaptation of skeletal myoblasts has been characterized with immunoflurescence microscopy during cell proliferation and differentiation. In particular, the dependence of the alignment efficiency on the dimensions of the microstructures was studied. The morphology difference of the myotubes in the three-dimensional tissues was reported. This paper holds the promise of efficient on-chip fabrication of skeletal muscle tissues and has an important implication in direct muscle repair and muscular mechanics.

Keywords

microstructuretissuemicroelectro-mechanical (MEMS)
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1052: Symposium DD – Microelectromechanical Systems–Materials and Devices , 2007 , 1052-DD03-27
Copyright
Copyright © Materials Research Society 2008

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