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Oligonuleotide Delivery with Dendritic Poly(L-lysine) for Treatments of the Liver Disorders

Published online by Cambridge University Press:  31 January 2011

Kazuto Watanabe ,
Mriko Harada-Shiba ,
Akira Suzuki ,
Yuriko Higuchi ,
Shigeru Kawakami ,
Mitsuru Hashida ,
Risa Gokuden ,
Ryohsuke Kurihara ,
Yusuke Sugao  and
Takeshi Mori
...Show all authors
Kazuto Watanabe
Affiliation:
kazuto@mail.cstm.kyushu-u.ac.jp, Kyushu University, Department of Applied Chemistry, Fukuoka, Japan
Mriko Harada-Shiba
Affiliation:
mshiba@ri.ncvc.go.jp, National Cardiovascular Center Research Institute, Department of Bioscience, Osaka, Japan
Akira Suzuki
Affiliation:
asuzuki@ri.ncvc.go.jp, National Cardiovascular Center Research Institute, Department of Bioscience, Osaka, Japan
Yuriko Higuchi
Affiliation:
higuchi@pharm.kyoto-u.ac.jp, Kyoto University, Department of Drug Delivery Research, Kyoto, Japan
Shigeru Kawakami
Affiliation:
kawakami@pharm.kyoto-u.ac.jp, Kyoto University, Department of Drug Delivery Research, Kyoto, Japan
Mitsuru Hashida
Affiliation:
hashidam@pharm.kyoto-u.ac.jp, Kyoto University, Department of Drug Delivery Research, Kyoto, Japan
Risa Gokuden
Affiliation:
risa.g@mail.cstm.kyushu-u.ac.jp, Kyushu University, Department of Applied Chemistry, Fukuoka, Japan
Ryohsuke Kurihara
Affiliation:
r-kurihara@mail.cstm.kyushu-u.ac.jp, Kyushu University, Department of Applied Chemistry, Fukuoka, Japan
Yusuke Sugao
Affiliation:
s-you@mail.cstm.kyushu-u.ac.jp, Kyushu University, Department of Applied Chemistry, Fukuoka, Japan
Takeshi Mori
Affiliation:
mori.takeshi.880@m.kyushu-u.ac.jp, Kyushu University, Department of Applied Chemistry, Fukuoka, Japan
Yoshiki Katayama
Affiliation:
ykatatcm@mbox.nc.kyushu-u.ac.jp, Kyushu University, Department of Applied Chemistry, Fukuoka, Japan
Takuro Niidome
Affiliation:
niidome.takuro.655@m.kyushu-u.ac.jpniidome-tcm@mbox.nc.kyushu-u.ac.jp, Kyushu University, Department of Applied Chemistry, Fukuoka, Japan
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Abstract

A cationic peptide dendrier, dendritic poly(L-lysine), forms complexes with oligonucleotides and can deliver them to liver after intravenous injection. Here, we tried to deliver apolipoprotein B-specific siRNA for the treatment of hypercholesterolemia and NFκB decoy for the hepatitis treatment. Significant therapeutic effects in those disease model mice were observed after intravenous injection of the oligonucleotides complexes with dendritic poly(L-lysine).

Keywords

biomaterialnanoscalepolymer
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1237: Symposium TT – Nanobiotechnology and Nanobiophotonics - Opportunities and Challenges , 2009 , 1237-TT05-12
Copyright
Copyright © Materials Research Society 2010

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References

1 Ohsaki, M. Okuda, T. Wada, A. Hirayama, T. Niidome, T. and Aoyagi, H. Bioconjugate Chem. 13, 510, (2002).Google Scholar
2 Okuda, T. Kidoaki, S. Ohsaki, M. Koyama, Y. Yoshikawa, K. Niidome, T. and Aoyagi, H. Org. Biomol. Chem. 1, 1270 (2003).Google Scholar
3 Okuda, T. Sugiyama, A. Niidome, T. and Aoyagi, H. Biomaterials 25, 537 (2004).Google Scholar
4 Yamagata, M. Kawano, T. Shiba, K. Mori, T. Katayama, Y. and Niidome, T. Bioorg. Med. Chem. 15, 526, (2007).Google Scholar
5 Inoue, Y. Kurihara, R. Tsuchida, A. Hasegawa, M. Nagashima, T. Nagas, Mori, T. Niidome, T. Katayama, Y. and Okitsu, O. J. Control. Release. 126, 59, (2008).Google Scholar
6 Kawano, T. Okuda, T. Aoyagi, H. Niidome, T. J. Control. Release 99, 329, (2004).Google Scholar
7 Soutschek, J. Akinc, A. Bramlage, B. Charisse, K. Constien, R. Donoghue, M. Elbashir, S. Elbashi, Geick, A., Hadwiger, P. Harborth, J. John, M. Kesavan, V. Lavine, G. Pandey, R. K. Racie, T. Rajeev, K. G. Rohl, I. Toudjarska, I. Wang, G. Wuschko, S. Bumcrot, D. Koteliansky, V. Limmer, S., Manoharan, M. and Vornlocher, H. H.-P., Nature 432, 173, (2004).Google Scholar
8 Rozema, D. B B., Lewis, D. L. Wakefield, D. H. Wong, S. C. . Klein, J. J. Roesch, P. L. Bertin, S. L., Reppen, T. W. Chu, Q. Blokhin, A. V. Hagstrom, J. E. and Wolff, J. A. Proc. Natl. Acad. Sci. 104, 12982, (2007).Google Scholar
9 Harada-Shiba, M., Takagi, A. Marutsuka, K. Moriguchi, S., Yagyu, H., Ishibashi, S. Asada, Y. Yokoyama, S., Circ. Res. 29, 945, (2004).Google Scholar
10 Galanos, C. Freudenberg, M., Reutter, W., Proc. Natl. Acad. Sci. 76, 5939, (1979).Google Scholar
11 Keller, M. J. Control. Release 103, 537, (2005).Google Scholar
12 Cannon, C. P. Braunwald, E. McCabe, C. H. Rader, D. J., Rouleau, J. L. Belder, R. Joyal, S. V., Hill, K. A. Pfeffer, M. A. and Skene, A. M. N. Engl. J. Med. 350, 1495, (2004).Google Scholar
13 Zadelaar, S. Kleemann, R. Verschuren, L. Weij, J. V. V.-V., Hoorn, J. Princen, H. M. and Kooistra, T., Arte Arterioscler. Thromb. rioscler. Vasc. Biol. 27, 1706 (2007).Google Scholar
14 Bielinska, A. Shivdasani, R. A. Zhang, L. Q. Nabel, G. J. Science 250, 997, (1990).Google Scholar
15 Higuchi, Y. Kawakami, S. Yamashita, F. Hashida, M. Biomaterials 28, 532, (2007).Google Scholar
16 Nakama, T. Hirono, S. Moriuchi, A. Hasuike, S. Nagata, K. Hori, T. Ido, A. Hayashi, K. Tsubouchi, H., Hepatology 33, 1441 , (2001).Google Scholar