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Tissue Scaffold Engineering by Micro-Stamping

Published online by Cambridge University Press:  04 February 2014

Eric C. Schmitt ,
Robert D. White ,
Amrit Sagar  and
Thomas P. James
Eric C. Schmitt
Affiliation:
Mechanical Engineering, Tufts University, Medford, MA 02155, U.S.A.
Robert D. White
Affiliation:
Mechanical Engineering, Tufts University, Medford, MA 02155, U.S.A.
Amrit Sagar
Affiliation:
Mechanical Engineering, Tufts University, Medford, MA 02155, U.S.A.
Thomas P. James
Affiliation:
Mechanical Engineering, Tufts University, Medford, MA 02155, U.S.A.
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Abstract

A hand operated benchtop stamping press was developed to conduct research on microscale hole fabrication in polymer membranes for applications as scaffolds in tissue engineering. A biocompatible and biodegradable polymer, poly(ε-caprolactone), was selected for micropunching. Membranes between 30 μm and 50 μm thick were fabricated by hot melt extrusion, but could not be stamped with a 200 μm circular punch at room temperature, regardless of die clearance due to excessive strain to fracture. This problem was overcome by cooling the membrane and die sets with liquid nitrogen to take advantage of induced brittle behavior below the polymer’s glass transition temperature. While cooled, 203 μm hole patterns were successfully punched in 33 μm thick poly(ε-caprolactone) membranes with 11% die clearance, achieving 71% porosity.

Keywords

biomaterialporositymicrostructure
Type
Articles
Information
MRS Online Proceedings Library (OPL) , Volume 1626: Symposium K – Micro- and Nanoscale Processing of Materials for Biomedical Devices , 2014 , mrsf13-1626-k05-06
Copyright
Copyright © Materials Research Society 2014 

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References

REFERENCES

Zorlutuna, P., Annabi, N., Camci-Unal, G., Nikkhah, M., Cha, J. M., Nichol, J. W., Manbachi, A., Bae, H., Chen, S., and Khademhosseini, A., Adv. Materials 24, 1782 (2012).CrossRefGoogle Scholar
Hutmacher, D. W., Journal of Biomaterials Science, Polymer Edition 12, 107–124 (2001).CrossRefGoogle Scholar
Hutmacher, D. W., Sittinger, M., and V Risbud, M., TRENDS in Biotechnology 22, 354 (2004).CrossRefGoogle Scholar
Hutmacher, Dietmar W., Biomaterials, 21, 2529 (2000).CrossRefGoogle Scholar
Guillemette, M. D., Park, H., Hsiao, J. C., Jain, S. R., Larson, B. L., Langer, R., and Freed, L. E., Macromolecular Bioscience 10, 1330–1337 (2010).CrossRefGoogle Scholar
Neal, R. A., Jean, A., Park, H., Wu, P. B., Hsiao, J., Engelmayr, G. C. Jr, Langer, R., and Freed, L. E., Tissue Engineering Part A 19, 793–807 (2012).CrossRefGoogle Scholar
Joo, BY, Oh, SI, and Jeon, BH, CIRP Annals-Manufacturing Technology 50, 191–194 (2001).CrossRefGoogle Scholar
Joo, BY, Rhim, SH, and Oh, SI, J. of Materials Processing Technology 170, 593–601 (2005).CrossRefGoogle Scholar
Rhim, SH, Son, YK, and Oh, SI, CIRP Annals-Manufacturing Technology 54, 261–264 (2005).CrossRefGoogle Scholar
Chern, Gwo-Lianq and Wang, Sen-De, Precision Engineering 31, 210–217 (2007).CrossRefGoogle Scholar
Xu, J., Guo, B., Shan, D., Wang, C., Li, J., Liu, Y., and Qu, D., Journal of Materials Processing Technology 212, 2238 (2012).CrossRefGoogle Scholar
Kolleck, R, Vollmer, R, and Veit, R, CIRP Annals-Manufacturing Technology 60, 331 (2011).CrossRefGoogle Scholar