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Use of sub-10 nm Diameter Upconversion Nanophosphors as Bio-labels

Published online by Cambridge University Press:  01 February 2011

Shuang Fang Lim ,
Robert Riehn ,
Chih-Kuan Tung ,
David Tank ,
William S. Ryu ,
Nan Yao  and
Robert H. Austin
Shuang Fang Lim
Affiliation:
sflim@Princeton.EDU, North Carolina State University, Physics, Campus Box 8202, Raleigh, NC, 27695, United States, 9195130841, 9195130841
Robert Riehn
Affiliation:
rriehn@ncsu.edu, North Carolina State University, Physics, Campus Box 8202, Raleigh, NC, 27695, United States
Chih-Kuan Tung
Affiliation:
ctung@Princeton.edu, Princeton University, Physics, Jadwin Hall, Princeton, NJ, 08544, United States
David Tank
Affiliation:
dwtank@princeton.edu, Princeton University, Physics, Jadwin Hall, Princeton, NJ, 08544, United States
William S. Ryu
Affiliation:
wsryu@Princeton.edu, Princeton University, Lewis-Sigler Institute for Integrative Genomics, Princeton, NJ, 08544, United States
Nan Yao
Affiliation:
nyao@Princeton.edu, Princeton University, PRISM, Princeton, NJ, 08544, United States
Robert H. Austin
Affiliation:
austin@Princeton.edu, Princeton University, Physics, Jadwin Hall, Princeton, NJ, 08544, United States
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Abstract

We have synthesized rare-earth doped sub-10 nm diameter upconverting yttrium oxide based nanophosphors by flame spray pyrolysis. We have investigated the emitted visible fluorescence of the sub-10nm nanophosphors under both infrared excitation and electron excitation, and observed comparable narrow band emission spectra. The viability of the nanoparticles for biological imaging was confirmed by imaging the digestive system of the nematode worm C. elegans in the upconversion mode. We have surface functionalized the nanophosphors making them suitable for bio labeling.

Keywords

nanoscalelanthanideflame synthesis
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 950: Symposium D – Biosurfaces and Biointerfaces , 2006 , 0950-D01-04
Copyright
Copyright © Materials Research Society 2007

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References

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