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Poly Lactic-Co-Glycolic Acid Carbon Nanofiber Composite for Enhancing Cardiomyocyte Function

Published online by Cambridge University Press:  25 March 2011

David A. Stout ,
Jennie Yoo  and
Thomas J. Webster
David A. Stout
Affiliation:
School of Engineering, Brown University, Providence, RI 02912, U.S.A.
Jennie Yoo
Affiliation:
Division of Biology and Medicine, Brown University, RI. 02912, U.S.A.
Thomas J. Webster
Affiliation:
School of Engineering, Brown University, Providence, RI 02912, U.S.A. Department of Orthopedics, Brown University, RI. 02912, U.S.A.
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Abstract

The objective of the present in vitro research was to determine cardiomyocyte function on poly lactic-co-glycolic acid (50:50 (PLA:PGA); PLGA) with greater amounts of carbon nanofibers (CNFs) and variations in CNF size, for myocardial tissue engineering applications. The addition of CNFs would increase conductivity and strength of pure PLGA. For this reason, different PLGA: CNF ratios (100:0, 75:25, 50:50, 25:75, 0:100 wt.%) were created and conductivity and cytocompatibility properties with human cardiomyocytes were determined. Results showed that PLGA:CNF materials were conductive and that conductivity increased with greater amounts of PLGA added, from 0 S.m-1 for 100:0 wt.% (pure PLGA) to 5.5x10-3 S.m-1 for 0:100 wt.% (pure CNFs) material. Furthermore, results indicated that cardiomyocyte density increased with greater amounts of CNFs of 200nm in diameter in PLGA (up to 25:75 wt.% , PLGA:CNFs). This study, thus, provided an alternative conductive scaffold using nanotechnology which should be further explored for cardiovascular applications.

Keywords

adhesionbiomaterialcompound
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1316: Symposium QQ – Nanofunctional Materials, Nanostructures and Nanodevices for Biomedical Applications II , 2011 , mrsf10-1316-qq06-33
Copyright
Copyright © Materials Research Society 2011

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References

REFERENCES

1. Locca, D., et al. , “New Universal Definition of Myocardial Infarction: Applicable After Complex Percutaneous Coronary Interventions,” JACC: Cardiovascular Interventions, vol. 3, pp. 950–958, 2010.Google Scholar
2. Thygesen, K. et al. , “Universal Definition of Myocardial Infarction,” Journal of the American College of Cardiology, vol. 50, pp. 2173–2195, 2007.Google Scholar
3. Jain, A. K. and Knight, C., “Myocardial infarction - new definitions and implications,” Medicine, vol. 38, pp. 421–423, 2010.Google Scholar
4. WRITING GROUP MEMBERS, et al. , “Heart Disease and Stroke Statistics–2009 Update: A Report From the American Heart Association Statistics Committee and Stroke Statistics Subcommittee,” Circulation, vol. 119, pp. e21-181, January 27, 2009 2009.Google Scholar
5. Pedrotty, D. M., et al. , “Engineering skeletal myoblasts: roles of three-dimensional culture and electrical stimulation,” Am J Physiol Heart Circ Physiol, vol. 288, pp. H1620-1626, April 1, 2005 2005.Google Scholar
6. Mihardja, S. S., et al. , “The effect of polypyrrole on arteriogenesis in an acute rat infarct model,” Biomaterials, vol. 29, pp. 4205–4210, 2008.Google Scholar
7. Yang, L., et al. , “The impact of diamond nanocrystallinity on osteoblast functions,” Biomaterials, vol. 30, pp. 3458–3465, 2009.Google Scholar