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Use of a Multiple Lumen Cuff for Nerve Regeneration

Published online by Cambridge University Press:  15 February 2011

Raymond Greer ,
John Daniel ,
Etsuro Uemura ,
Raymond Kudej ,
Yueh-Sheng Chen  and
Chih-Hui Chung
Raymond Greer
Affiliation:
Biomedical Engineering Program, Iowa State University, Ames, IA 50011 Engineering Research Institute, Iowa State University, Ames, IA 50011
John Daniel
Affiliation:
Biomedical Engineering Program, Iowa State University, Ames, IA 50011
Etsuro Uemura
Affiliation:
Veterinary Anatomy, Iowa State University, Ames, IA 50011
Raymond Kudej
Affiliation:
Biomedical Engineering Program, Iowa State University, Ames, IA 50011
Yueh-Sheng Chen
Affiliation:
Biomedical Engineering Program, Iowa State University, Ames, IA 50011
Chih-Hui Chung
Affiliation:
Biomedical Engineering Program, Iowa State University, Ames, IA 50011
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Abstract

Initial studies using the rat sciatic nerve demonstrated the ability to adapt a multiple lumen cuff face to a nerve stump repair site. The neurons in the proximal stump grew through the individual conduits of the silicone rubber cuff, crossed a 5 mm gap, and continued into the distal stump. The effect of the cuff design on axonal regeneration was studied by comparing macroscopic and microstructural results for experimental groups of Sprague-Dawley rats with controls at 8, 12, 16, and 24 weeks post-implantation. The several individual nerve bundles which formed within the cuff lumens during these periods maintained their alignment on the distal side of the gap. The use of the multiple lumen system provided suitable scaffolding support and control of orientation and direction for fibers and established a sized, controlled environment for regeneration within each of the separate nerve cuff compartments.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 331: Symposium T – Biomaterials for Drug and Cell Delivery , 1993 , 3
Copyright
Copyright © Materials Research Society 1994

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References

1. Rosen, J. M., Padilla, J. A., Nguyen, K. D., Siedman, J., and Pham, H. N., J. Rehab. Res. and Dev. 29 (2), 1–12(1992).Google Scholar
2. Daniel, R. K. and Terzis, J. K., Reconstructive Microsurgery, (Little, Brown and Company, Boston, 1977), pp. 404–419.Google Scholar
3. Dellon, A. L. and Mackinnon, S. E., Plast. Reconstr. Surg. 82 (5), 849–856(1988).Google Scholar
4. Williams, L. R., Longo, F. M., Powell, H. C., Lundborg, G., and Varon, S., J. Comp. Neurol. 218, 460–470(1983).Google Scholar
5. Williams, L. R. and Varon, S., J. Comp. Neurol. 231, 209–220(1985).Google Scholar
6. Cuadros, C. L. and Granatir, C. E., Microsurg. 8, 41–46(1987).Google Scholar
7. Bassett, C. A. L., Campbell, J. B., and Husby, J., Exp. Neurol. 1, 386–406(1959).Google Scholar
8. Seckel, B. R., Chiu, T. H., Nyilas, E., and Sidman, R. L., Plast. Reconstr. Surg. 74 (2), 173–181(1984).Google Scholar
9. Mackinnon, S. E. and Dellon, A. L., Plast. Reconstr. Surg. 85 (3), 419–424(1990).Google Scholar
10. Rosen, J. M., Pham, H. N., Abraham, G., Harold, L., and Hentz, V. R., J. Rehab. Res. and Dev. 26 (1), 1–14(1989).Google Scholar
11. Henry, E. W., Chiu, T. H., Nyilas, E., Brushart, T. M., Dikkes, P., and Sidman, R. L., Exp. Neurol. 90, 652–676(1985).Google Scholar
12. Vejsada, R., Palecek, J., Hnik, P., and Soukup, T., Int. J. of Developmental Neorosci. 3 (5), 583–595(1985).Google Scholar
13. Swaim, S. F., in eterinary Neurology, edited by Oliver, J. E. Jr., Hoerlin, B. F., and Mayhew, I. G. (W. B. Saunders Co., Philadelphia, 1987) pp. 493–512.Google Scholar
14. Zellem, R. R., Miller, D. W., Kenning, J. A., Hoenig, E. M., and Buchheit, W. A., Microsurg. 10, 290–301(1989).Google Scholar
15. Mathur, A., Merrell, J. C., Russell, R. C., and Zook, E. G., Scan. Elect. Micros. Part II, 975–981(1983).Google Scholar
16. Jenq, C. B and Coggeshall, R. E., Brain Res. 364, 45–56(1986).Google Scholar
17. Mira, J. C., J. Anat. 129, 77–93(1979).Google Scholar
18. Espejo, F. and Alvarez, J., J. Comp. Neuro. 250, 65–72(1986).Google Scholar
19. Beau, J. M. Le, Ellisman, M. H., and Powell, H. C., J. Neurocytology 17, 161–172(1988).Google Scholar