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Antigenic variation in Trypanosoma vivax: isolation of a serodeme

Published online by Cambridge University Press:  06 April 2009

J. D. Barry  and
H. Gathuo
J. D. Barry
Affiliation:
International Laboratory for Research on Animal Diseases, P.O. Box 30709, Nairobi, Kenya
H. Gathuo
Affiliation:
International Laboratory for Research on Animal Diseases, P.O. Box 30709, Nairobi, Kenya
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Summary

Studies of antigenic variation in Trypanosoma vivax have been hindered by its low infectivity to laboratory hosts and difficulties in obtaining defined cloned populations. The recent isolation of mouse-infective T. vivax has partially overcome the first problem. We have developed a highly efficient cloning technique which has been applied to the isolation of a collection of 71 clones, representing 31 distinct variable antigen types, of mouse-infective T. vivax from Nigeria. This serodeme showed no cross-reaction with several T. brucei-group serodemes, but some cross-reaction with naturally occurring Kenyan T. vivax.

Type
Research Article
Information
Parasitology , Volume 89 , Issue 1 , August 1984 , pp. 49 - 58
Copyright
Copyright © Cambridge University Press 1984

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